A new type of lanthanum‐based high entropy perovskite oxide (HEPO) electrocatalyst for the oxygen evolution reaction is reported. The B‐site lattices in the HEPO consist of five consecutive first‐row ...transition metals, including Cr, Mn, Fe, Co, and Ni. Equimolar and five non‐equimolar HEPO electrocatalysts are studied for their OER electrocatalytic performance. In the five non‐equimolar HEPOs, the concentration of one of the five transition metals is doubled in individual samples. The performances of all the HEPOs outperform the single perovskite oxides. The optimized La(CrMnFeCo2Ni)O3 HEPO exhibits an outstanding OER overpotential of 325 mV at a current density of 10 mA cm−2 and excellent electrochemical stability after 50 h of testing.
Lanthanum‐based high entropy perovskite oxides (HEPOs) with a B‐site consisting of five consecutive first‐row transition metals are synthesized in both equimolar and non‐equimolar ratios. The HEPO electrocatalysts outperform the single perovskite oxides. The optimized La(CrMnFeCo2Ni)O3 HEPO exhibits an outstanding OER overpotential of 325 mV at 10 mA cm–2 and excellent stability after 50 h of testing.
Ischemia–reperfusion injury (IRI) is the major cause of acute kidney injury (AKI). The previous studies demonstrated that Oridonin can protect kidney against IRI-induced AKI, but the underlying ...molecular mechanism is unclear. In this study, it showed that Oridonin significantly improved kidney damage, and inhibited the expression of interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and MCP-1, as well as macrophage marker F4/80 in kidney and the secretion of inflammatory cytokins in serum of AKI mice in vivo. In addition, Oridonin also effectively reduced the expression and secretion of lipopolysaccharide (LPS)-induced inflammatory factors in macrophage cell line RAW264.7 in vitro. Notably, Oridonin strongly downregulated Mincle and AKT/nuclear factor-kappaB (NF-κB) signaling both in vivo and in vitro, and the results of cellular recovery experiments of overexpression of Mincle in macrophage suggested that Oridonin suppressed inflammatory response of macrophage through inhibiting Mincle, which may be the underlying mechanism of Oridonin improving injury in kidney of AKI mice. In summary, the above results indicated that Oridonin can protect kidney from IRI-induced inflammation and injury by inhibiting the expression of Mincle in macrophage.
This study develops a contingency framework to investigate how and when innovation intensity and creativity enhancement affect a firm's eco‐innovation strategy by drawing upon the perspectives of the ...resource‐based view and stakeholder theory. This investigation aims to explore whether firms with high innovation intensity and creativity enhancement really pursue eco‐innovation strategy. Our examination is based on a sample of 2,126 manufacturing firms. By using a hierarchical regression, the results reveal that the effects of innovation intensity and creativity enhancement on eco‐innovation strategy depend on customer demand and environmental regulation. Specifically, customer demand positively moderates the effects of innovation intensity and creativity enhancement on eco‐innovation strategy, whereas existing regulation has a weaker effect on the relationship between innovation activities and eco‐innovation strategy than that of anticipated regulation.
MicroRNA-34 (miR-34) has been reported to be dysregulated in various human cancers and regarded as a tumor suppressive microRNA because of its synergistic effect with the well-known tumor suppressor ...p53. Along with the application of MRX34, the first tumor-targeted microRNA drug which based on miR-34a mimics, on phase I clinical trial (NCT01829971), the significance of miR-34 is increasingly recognized. miR-34 plays a crucial role on repressing tumor progression by involving in epithelial-mesenchymal transition (EMT) via EMT- transcription factors, p53 and some important signal pathways. Not only that, numerous preclinical researches revealed the giant potential of miR-34a on cancer therapy through diversiform nano-scaled delivery systems. Here, we provide an overview about the function of miR-34 in various cancers and the mechanism of miR-34 in tumor-associated EMT. Furthermore, its potential role as a microRNA therapeutic candidate is also discussed. Notwithstanding some obstacles existed, the extensive application prospect of miR-34 on oncotherapy cannot be neglected.
For a Lie algebroid
L
and a Lie subalgebroid
A
, i.e. a Lie pair (
L
,
A
), we study the Atiyah class and the Todd class of the pullback dg (i.e. differential graded) Lie algebroid
π
!
L
of
L
along ...the bundle projection
π
:
A
1
→
M
of the shifted vector bundle
A
1. Applying the homological perturbation lemma, we provide a new construction of Stiénon–Vitagliano–Xu’s contraction relating the cochain complex
(
Γ
(
π
!
L
)
,
Q
)
of sections of
π
!
L
to the Chevalley–Eilenberg complex
(
Γ
(
Λ
∙
A
∨
⊗
(
L
/
A
)
)
,
d
Bott
)
of the Bott representation. Using this contraction, we construct two isomorphisms: the first identifies the cohomology of the cochain complex
(
Γ
(
(
π
!
L
)
∨
⊗
End
(
π
!
L
)
)
,
Q
)
with the Chevalley–Eilenberg cohomology
H
CE
∙
(
A
,
(
L
/
A
)
∨
⊗
End
(
L
/
A
)
)
arising from the Bott representation, while the second identifies the cohomologies
H
∙
(
Γ
(
Λ
(
π
!
L
)
∨
)
,
Q
)
and
H
CE
∙
(
A
,
Λ
(
L
/
A
)
∨
)
. We prove that this pair of isomorphisms identifies the Atiyah class and the Todd class of the dg Lie algebroid
π
!
L
with the Atiyah class and the Todd class of the Lie pair (
L
,
A
), respectively.
A
bstract
We investigate systematically dimension-9 operators in the standard model effective field theory which contains only standard model fields and respects its gauge symmetry. With the help of ...the Hilbert series approach to classifying operators according to their lepton and baryon numbers and their field contents, we construct the basis of operators explicitly. We remove redundant operators by employing various kinematic and algebraic relations including integration by parts, equations of motion, Schouten identities, Dirac matrix and Fierz identities, and Bianchi identities. We confirm counting of independent operators by analyzing their flavor symmetry relations. All operators violate lepton or baryon number or both, and are thus non-Hermitian. Including Hermitian conjugated operators there are
384
Δ
B
=
0
Δ
L
=
±
2
+
10
Δ
B
=
±
2
Δ
L
=
0
+
4
Δ
B
=
±
1
Δ
L
=
±
3
+
236
Δ
B
=
±
1
Δ
L
=
∓
1
operators without referring to fermion generations, and
44874
Δ
B
=
0
Δ
L
=
±
2
+
2862
Δ
B
=
±
2
Δ
L
=
0
+
486
Δ
B
=
±
1
Δ
L
=
±
3
+
42234
Δ
B
=
∓
1
Δ
L
=
±
1
operators when three generations of fermions are referred to, where ∆
L,
∆
B
denote the net lepton and baryon numbers of the operators. Our result provides a starting point for consistent phenomenological studies associated with dimension-9 operators.
Control of excited‐state dynamics is key in tuning room‐temperature phosphorescence (RTP) and thermally activated delayed fluorescence (TADF) emissions but is challenging for organic luminescent ...materials (OLMs). We show the regulation of TADF and RTP emissions of a boron difluoride β‐acetylnaphthalene chelate (βCBF2) by controlling the excited‐state dynamics via its J‐ and H‐aggregation states. Two crystalline polymorphs emitting green and red light have been controllably obtained. Although both monoclinic, the green and red crystals are dominated by J‐ and H‐aggregation, respectively, owing to different molecular packing arrangements. J‐aggregation significantly reduces the energy gap between the lowest singlet and triplet excited states for ultra‐fast reverse intersystem crossing (RISC) and enhances the radiative singlet decay, together leading to TADF. The H‐aggregation accelerates the ISC and suppresses the radiative singlet decay, helping to stabilize the triplet exciton for RTP.
J‐aggregates significantly reduce the energy gap between the lowest singlet (S1) and triplet (T1) excited states and contribute to the reverse intersystem crossing (RISC) process; while H‐aggregates will accelerate ISC and suppress radiation transition of S1 to realize phosphorescence. This provides crucial information for the deep undrstanding of the internal mechanism of the excited state dynamics controlled by different aggregates.
Measuring speed is a critical factor to reduce motion artifacts for dynamic scene capture. Phase-shifting methods have the advantage of providing high-accuracy and dense 3D point clouds, but the ...phase unwrapping process affects the measurement speed. This paper presents an absolute phase unwrapping method capable of using only three speckle-embedded phase-shifted patterns for high-speed three-dimensional (3D) shape measurement on a single-camera, single-projector structured light system. The proposed method obtains the wrapped phase of the object from the speckle-embedded three-step phase-shifted patterns. Next, it utilizes the Semi-Global Matching (SGM) algorithm to establish the coarse correspondence between the image of the object with the embedded speckle pattern and the pre-obtained image of a flat surface with the same embedded speckle pattern. Then, a computational framework uses the coarse correspondence information to determine the fringe order pixel by pixel. The experimental results demonstrated that the proposed method can achieve high-speed and high-quality 3D measurements of complex scenes.
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