We present a detailed multiwavelength characterization of the multi-ring disk of HD 169142. We report new Atacama Large Millimeter/submillimeter Array (ALMA) observations at 3 mm and analyze them ...together with archival 0.89 and 1.3 mm data. Our observations resolve three out of the four rings in the disk previously seen in high-resolution ALMA data. A simple parametric model is used to estimate the radial profile of the dust optical depth, temperature, density, and particle size distribution. We find that the multiple ring features of the disk are produced by annular accumulations of large particles, probably associated with gas pressure bumps. Our model indicates that the maximum dust grain size in the rings is ∼1 cm, with slightly flatter power-law size distributions than the interstellar medium-like size distribution (p ∼ 3.5) found in the gaps. In particular, the inner ring (∼26 au) is associated with a strong and narrow buildup of dust particles that could harbor the necessary conditions to trigger the streaming instability. According to our analysis, the snowlines of the most important volatiles do not coincide with the observed substructures. We explore different ring formation mechanisms and find that planet-disk interactions are the most likely scenario to explain the main features of HD 169142. Overall, our multiwavelength analysis provides some of the first unambiguous evidence of the presence of radial dust traps in the rings of HD 169142. A similar analysis in a larger sample of disks could provide key insights on the impact that disk substructures have on the dust evolution and planet formation processes.
Lipid nanoparticles serve as drug delivery vehicles for biopharmaceutical products. The lipid membrane shields internal nucleic-acid drug cargo from enzymatic degradation and facilitates cellular ...uptake of the drug. However, existing methods to assess drug loading within liposomes are limited to averaged bulk measurements, which obscures heterogeneity of the biopharmaceutical formulation. This report describes the development of a single-liposome analysis method to measure copy numbers of DNA within liposomes and assess population heterogeneity. This novel measurement was achieved by integrating two orthogonal polymerase chain reaction (PCR) techniques─digital PCR (dPCR) and quantitative PCR (qPCR)─within a single microfluidic assay. The dPCR dimension quantified liposomes to validate their capture in the single-liposome analysis regime. The qPCR dimension quantified DNA copy numbers packaged within each liposome. The ability of digital quantitative PCR (dqPCR) to analyze large numbers of individual liposomes in parallel revealed significant population heterogeneity, which could not be obtained from standard bulk analysis methods. Our innovative measurement of internal DNA cargo from single liposomes has the potential to inform liposome synthesis procedures and create more uniform liposomal biopharmaceutical formulations to enhance drug safety and efficacy.
We present SOFIA/FIFI-LS observations of the C ii 158 m cooling line across the nearby spiral galaxy NGC 6946. We combine these with UV, IR, CO, and H i data to compare C ii emission to dust ...properties, star formation rate (SFR), H2, and H i at 560 pc scales via stacking by environment (spiral arms, interarm, and center), radial profiles, and individual, beam-sized measurements. We attribute 73% of the C ii luminosity to arms, and 19% and 8% to the center and interarm region, respectively. C ii/TIR, C ii/CO, and C ii/PAH radial profiles are largely constant, but rise at large radii ( 8 kpc) and drop in the center ("C ii deficit"). This increase at large radii and the observed decline with the 70 m/100 m dust color are likely driven by radiation field hardness. We find a near proportional C ii-SFR scaling relation for beam-sized regions, though the exact scaling depends on methodology. C ii also becomes increasingly luminous relative to CO at low SFR (interarm or large radii), likely indicating more efficient photodissociation of CO and emphasizing the importance of C ii as an H2 and SFR tracer in such regimes. Finally, based on the observed C ii and CO radial profiles and different models, we find CO to increase with radius, in line with the observed metallicity gradient. The low CO (galaxy average 2 M pc−2 (K km s−1)−1) and low C ii/CO ratios (∼400 on average) imply little CO-dark gas across NGC 6946, in contrast to estimates in the Milky Way.
Context.
Recent surveys of the Galactic plane in the dust continuum and CO emission lines reveal that large (≳50 pc) and massive (≳10
5
M
⊙
) filaments, know as giant molecular filaments (GMFs), may ...be linked to Galactic dynamics and trace the mid-plane of the gravitational potential in the Milky Way. Yet our physical understanding of GMFs is still poor.
Aims.
We investigate the dense gas properties of one GMF, with the ultimate goal of connecting these dense gas tracers with star formation processes in the GMF.
Methods.
We imaged one entire GMF located at
l
~ 52–54° longitude, GMF54 (~68 pc long), in the empirical dense gas tracers using the HCN(1–0), HNC(1–0), and HCO
+
(1–0) lines, and their
13
C isotopologue transitions, as well as the N
2
H
+
(1–0) line. We studied the dense gas distribution, the column density probability density functions (N-PDFs), and the line ratios within the GMF.
Results.
The dense gas molecular transitions follow the extended structure of the filament with area filling factors between 0.06 and 0.28 with respect to
13
CO(1–0). We constructed the N-PDFs of H
2
for each of the dense gas tracers based on their column densities and assumed uniform abundance. The N-PDFs of the dense gas tracers appear curved in log–log representation, and the HCO
+
N-PDF has the flattest power-law slope index. Studying the N-PDFs for sub-regions of GMF54, we found an evolutionary trend in the N-PDFs that high-mass star-forming and photon-dominated regions have flatter power-law indices. The integrated intensity ratios of the molecular lines in GMF54 are comparable to those in nearby galaxies. In particular, the N
2
H
+
/
13
CO ratio, which traces the dense gas fraction, has similar values in GMF54 and all nearby galaxies except Ultraluminous Infrared Galaxies.
Conclusions.
As the largest coherent cold gaseous structure in our Milky Way, GMFs, are outstanding candidates for connecting studies of star formation on Galactic and extragalactic scales. By analyzing a complete map of the dense gas in a GMF we have found that: (1) the dense gas N-PDFs appear flatter in more evolved regions and steeper in younger regions, and (2) its integrated dense gas intensity ratios are similar to those of nearby galaxies.
Context. For over a decade, the structure of the inner cavity in the transition disk of TW Hydrae has been a subject of debate. Modeling the disk with data obtained at different wavelengths has led ...to a variety of proposed disk structures. Rather than being inconsistent, the individual models might point to the different faces of physical processes going on in disks, such as dust growth and planet formation. Aims. Our aim is to investigate the structure of the transition disk again and to find to what extent we can reconcile apparent model differences. Methods. A large set of high-angular-resolution data was collected from near-infrared to centimeter wavelengths. We investigated the existing disk models and established a new self-consistent radiative-transfer model. A genetic fitting algorithm was used to automatize the parameter fitting, and uncertainties were investigated in a Bayesian framework. Results. Simple disk models with a vertical inner rim and a radially homogeneous dust composition from small to large grains cannot reproduce the combined data set. Two modifications are applied to this simple disk model: (1) the inner rim is smoothed by exponentially decreasing the surface density in the inner ~3 AU, and (2) the largest grains (>100 μm) are concentrated towards the inner disk region. Both properties can be linked to fundamental processes that determine the evolution of protoplanetary disks: the shaping by a possible companion and the different regimes of dust-grain growth, respectively. Conclusions. The full interferometric data set from near-infrared to centimeter wavelengths requires a revision of existing models for the TW Hya disk. We present a new model that incorporates the characteristic structures of previous models but deviates in two key aspects: it does not have a sharp edge at 4 AU, and the surface density of large grains differs from that of smaller grains. This is the first successful radiative-transfer-based model for a full set of interferometric data.
ABSTRACT The first long-baseline ALMA campaign resolved the disk around the young star HL Tau into a number of axisymmetric bright and dark rings. Despite the very young age of HL Tau, these ...structures have been interpreted as signatures for the presence of (proto)planets. The ALMA images triggered numerous theoretical studies based on disk-planet interactions, magnetically driven disk structures, and grain evolution. Of special interest are the inner parts of disks, where terrestrial planets are expected to form. However, the emission from these regions in HL Tau turned out to be optically thick at all ALMA wavelengths, preventing the derivation of surface density profiles and grain-size distributions. Here, we present the most sensitive images of HL Tau obtained to date with the Karl G. Jansky Very Large Array at 7.0 mm wavelength with a spatial resolution comparable to the ALMA images. At this long wavelength, the dust emission from HL Tau is optically thin, allowing a comprehensive study of the inner disk. We obtain a total disk dust mass of (1-3) × 10−3 M , depending on the assumed opacity and disk temperature. Our optically thin data also indicate fast grain growth, fragmentation, and formation of dense clumps in the inner densest parts of the disk. Our results suggest that the HL Tau disk may be actually in a very early stage of planetary formation, with planets not already formed in the gaps but in the process of future formation in the bright rings.
ABSTRACT
We report the detection of new 12.178, 12.229, 20.347, and 23.121 GHz methanol masers in the massive star-forming region G358.93−0.03, which are flaring on similarly short time-scales (days) ...as the 6.668 GHz methanol masers also associated with this source. The brightest 12.178 GHz channel increased by a factor of over 700 in just 50 d. The masers found in the 12.229 and 20.347 GHz methanol transitions are the first ever reported and this is only the fourth object to exhibit associated 23.121 GHz methanol masers. The 12.178 GHz methanol maser emission appears to have a higher flux density than that of the 6.668 GHz emission, which is unusual. No associated near-infrared flare counterpart was found, suggesting that the energy source of the flare is deeply embedded.
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