Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments of transcriptomic ...organization in diseased brains are limited. In this work, we integrated genotypes and RNA sequencing in brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, and bipolar disorder, as well as controls. More than 25% of the transcriptome exhibits differential splicing or expression, with isoform-level changes capturing the largest disease effects and genetic enrichments. Coexpression networks isolate disease-specific neuronal alterations, as well as microglial, astrocyte, and interferon-response modules defining previously unidentified neural-immune mechanisms. We integrated genetic and genomic data to perform a transcriptome-wide association study, prioritizing disease loci likely mediated by cis effects on brain expression. This transcriptome-wide characterization of the molecular pathology across three major psychiatric disorders provides a comprehensive resource for mechanistic insight and therapeutic development.
Purpose As a counterproductive interpersonal work behavior, knowledge hiding inhibits team creativity, hampers collaboration and ultimately has a detrimental impact on organizational performance. ...Drawing upon the impression management perspective. This study aims to investigate how and when employees’ political skill affects their knowledge-hiding behavior in real work contexts. Design/methodology/approach The authors tested the hypotheses using data gathered from 266 employees in China using a time-lagged research design. Findings The results indicate that political skill positively influences knowledge hiding through the supplication strategy. Moreover, the positive effect of political skill on this strategy is stronger under higher levels of competition. Research limitations/implications A cross-sectional design and the use of self-report questionnaires are the limitations of this study. Originality/value The authors contribute to the literature on the emergence of knowledge hiding by identifying an impression management perspective. The authors also contribute to the literature on political skill by exploring the potential negative effects of political skill in the interpersonal interaction. Moreover, the authors enrich the understanding of the literature in competitive climate by introducing the impression management theory and exploring its influence on knowledge floating.
Health concerns regarding the potential interference of endocrine disrupting chemicals (EDCs) in the immune system of wildlife and humans have increased in recent years. However, the effects of EDCs ...in aquatic systems on the immune system of fish species has only received limited attention. In the present study, we found that the mRNA levels of TNFα, IFN, IL-1β, IL-8, CXCL-Clc, and CC-chemokine, which are closely related to the innate immune system, were affected in newly hatched zebrafish when exposed to EDCs, such as 17β-estradiol, 17α-ethynyestradiol, permethrin, atrazine and nonylphenol at various concentrations (0.1, 0.5, 2.5 and 12.5 μg/l) for three days during the embryo stage. However, the different EDCs displayed different potentials to change innate immune-related gene transcription. Among the selected chemicals, permethrin (PM) and 17β-estradiol (E2) (12.5 μg/l) significantly increased the mRNA levels of many cytokines, exhibiting their most prominent impacts on the innate immune system of zebrafish. In addition, it was found that the mixture of the above five chemicals (2.5 μg/l each) had a greater effect on innate immune system-related gene transcription in zebrafish than equal amounts of the single compound. Moreover, the genes (such as Bcl2, Ucp2 and iNOS) relating to reactive oxygen species (ROS) and nitrogen reactive free radical production were also influenced by some EDCs and their mixture. We suggest that heavy oxidative stress and the balance of nitric oxide (NO) production lead to death of immune cells. These results may provide an explanation of the possible mode how EDCs influence the innate immune system in zebrafish. Taken together, the results obtained in the present study clearly demonstrate that EDCs and their mixtures in aquatic systems will greatly influence the immune system in fish, suggesting that the effects of EDCs on fish should be associated with immune toxicity.
•Hierarchical porous covalent organic framework was utilized for the preconcentration of sulfonamides (SAs).•COF foam exhibited superior extraction performance and good durability for SAs ...preconcentration.•The developed SPE-HPLC method achieved a wide linearity, low LODs, and good accuracy.•The analysis of SAs in meat samples were achieved with satisfactory recoveries (85.0-113.8%).
In this work, hierarchical porous covalent organic frameworks (HP-COFs) foam, named as HP-TpBD, was prepared by using 1,3,5-trimethylphloroglucinol (Tp) and benzidine (BD) as building blocks under the assistant of NaCl template. Its potential application as the sorbent for solid phase extraction (SPE) of sulfonamides (SAs) in meat products were explored by coupling with high performance liquid chromatography-mass spectrum (HPLC-MS) analysis. The key factors affecting extraction efficiency were well studied. Under the optimum conditions, the proposed method exhibited high preconcentration factors of 100, low limit of detection (0.10-0.23 μg/kg), and wide linear ranges (0.5-200 μg/kg). In addition, the determination of SAs in real samples were realized with satisfactory recoveries (82.8-119.9%), demonstrating the applicability of the proposed method. The easy operation, superior extraction affinity and good recycle performance demonstrated the resulting HP-COF foam is a promising adsorbent for the preconcentration of trace organic compounds from complex matrix.
Photothermal ablation (PTA) therapy has a great potential to revolutionize conventional therapeutic approaches for cancers, but it has been limited by difficulties in obtaining biocompatible ...photothermal agents that have low cost, small size (<100 nm), and high photothermal conversion efficiency. Herein, we have developed hydrophilic plate-like Cu(9)S(5) nanocrystals (NCs, a mean size of ∼70 nm × 13 nm) as a new photothermal agent, which are synthesized by combining a thermal decomposition and ligand exchange route. The aqueous dispersion of as-synthesized Cu(9)S(5) NCs exhibits an enhanced absorption (e.g., ∼1.2 × 10(9) M(-1) cm(-1) at 980 nm) with the increase of wavelength in near-infrared (NIR) region, which should be attributed to localized surface plasmon resonances (SPR) arising from p-type carriers. The exposure of the aqueous dispersion of Cu(9)S(5) NCs (40 ppm) to 980 nm laser with a power density of 0.51 W/cm(2) can elevate its temperature by 15.1 °C in 7 min; a 980 nm laser heat conversion efficiency reaches as high as 25.7%, which is higher than that of the as-synthesized Au nanorods (23.7% from 980 nm laser) and the recently reported Cu(2-x)Se NCs (22% from 808 nm laser). Importantly, under the irradiation of 980 nm laser with the conservative and safe power density over a short period (∼10 min), cancer cells in vivo can be efficiently killed by the photothermal effects of the Cu(9)S(5) NCs. The present finding demonstrates the promising application of the Cu(9)S(5) NCs as an ideal photothermal agent in the PTA of in vivo tumor tissues.
Tunnel linings would suffer heavy structural damage or even collapse when exposed to a long-duration fire. The damage is greatly affected by heating time. In this paper, a theoretical method is ...suggested to investigate the thermo-mechanical behaviors of tunnel lining subjected to a long-duration fire loading. A 2D unsteady-state thermo-mechanical model is established to analyze the time-dependent temperature and stresses distributions of tunnel lining under fire. A modified RABT fire curve is employed to describe the tunnel fire development. By using Laplace Transform and series solving method for ordinary differential equations (ODE), the analytical solutions of time-dependent temperature and stresses are obtained and numerically verified. Based on the temperature criterion and the residual stress criterion, damage evolution of tunnel lining is graphically presented and discussed. According to the comparison results, the consistence of these two criteria is theoretically verified.
Copper sulphides, as a novel kind of photothermal agent for photothermal therapy (PTT) of cancer cells, have attracted increasing attention in recent years due to good photostability, synthetic ...simplicity, low toxicity and low cost. However, the unsatisfactory photothermal conversion efficiency of copper sulphides limits their bioapplication as PTT agents. Herein, Cu7.2S4 NCs with a mean size of ∼20 nm as a novel photothermal agent have been prepared by a simple thermal decomposition route. Moreover, these NCs exhibit strong near-infrared (NIR) absorption, good photostability and significant photothermal conversion efficiency up to 56.7% due to strong NIR absorption, good dispersity and suitable size. Importantly, these NCs can be very compatibly used as a 980 nm laser-driven PTT agent for the efficient PTT of cancer cells in vitro and in vivo.
Fabrication of a high‐temperature deep‐ultraviolet photodetector working in the solar‐blind spectrum range (190–280 nm) is a challenge due to the degradation in the dark current and photoresponse ...properties. Herein, β‐Ga2O3 multi‐layered nanobelts with (l00) facet‐oriented were synthesized, and were demonstrated for the first time to possess excellent mechanical, electrical properties and stability at a high temperature inside a TEM studies. As‐fabricated DUV solar‐blind photodetectors using (l00) facet‐oriented β‐Ga2O3 multi‐layered nanobelts demonstrated enhanced photodetective performances, that is, high sensitivity, high signal‐to‐noise ratio, high spectral selectivity, high speed, and high stability, importantly, at a temperature as high as 433 K, which are comparable to other reported semiconducting nanomaterial photodetectors. In particular, the characteristics of the photoresponsivity of the β‐Ga2O3 nanobelt devices include a high photoexcited current (>21 nA), an ultralow dark current (below the detection limit of 10−14 A), a fast time response (<0.3 s), a high Rλ (≈851 A/W), and a high EQE (∼4.2 × 103). The present fabricated facet‐oriented β‐Ga2O3 multi‐layered nanobelt based devices will find practical applications in photodetectors or optical switches for high‐temperature environment.
Deep ultraviolet solar‐blind photodetectors based on a (l00) facet‐oriented β‐Ga2O3 multi‐layered nanobelt are fabricated. As‐fabricated photodetectors demonstrate enhanced photodetective performances, that is, high stability, high signal‐to‐noise ratio, high spectral selectivity, high sensitivity and fast time response at temperatures as high as 433 K, which make them excellent candidates for photodetectors or optical switches.
A large-scale of MoO3/PANI coaxial heterostructure nanobelts have been fabricated for high-performance supercapacitors via a simple and green approach without any surfactant. Herein, the assembly of ...PANI conductive layer on the surface of the well-crystallized α-MoO3 nanobelts was carried out using ammonium persulfate (APS) as oxidant by in-situ polymerization at room temperature. As-prepared MoO3/PANI coaxial heterostructure nanobelts have been successfully employed as supercapacitor electrodes. It was found that the as-synthesized MoO3/PANI coaxial heterostructure nanobelts exhibited excellent supercapacitor performance with high specific capacitances of 714Fg−1 at a scan rate of 1mVs−1 and 632Fg−1 at a current density of 1Ag−1 in 1M H2SO4 electrolyte, whereas the original α-MoO3 nanobelts just showed initial specific capacitances of 275Fg−1 and 267Fg−1 at 1mVs−1 and 1Ag−1, respectively, which attributed to the synergic effect between the PANI coating and the original α-MoO3 nanobelts.
Novel MoO3/PANI coaxial heterostructure nanobelts fabricated on a large-scale by a simple and green approach without any surfactant exhibits high specific capacitance of 714Fg−1 at a scan rate of 1mVs−1 and 632Fg−1 at a current density of 1Ag−1, as well as good cycling stability (76.7% of capacity retention after 3000 cycles). Display omitted
•Well-crystallized α-MoO3 nanobelts were prepared by a hydrothermal method.•MoO3/PANI coaxial nanobelts were carried out via a simple and green approach.•The coaxial heterostructure nanobelt shows superior supercapacitor performance.•A high specific capacitance of 714Fg−1 at 1mVs−1 in 1M H2SO4 electrolyte.
Objective The predictive biomarkers of immune checkpoint inhibitors (ICIs) in hepatocellular carcinoma (HCC) still need to be further explored. This study aims to establish a new immune prognosis ...biomarker to predict the clinical outcomes of hepatocellular carcinoma patients receiving immune checkpoint inhibitors. Methods The subjects of this study were 151 HCC patients receiving ICIs at Harbin Medical University Cancer Hospital from January 2018 to December 2021. This study collected a wide range of blood parameters from patients before treatment and used Cox's regression analysis to identify independent prognostic factors in blood parameters, as well as their beta coefficient. The hepatocellular carcinoma immune prognosis score (HCIPS) was established through Lasso regression analysis and COX multivariate analysis. The cut-off value of HCIPS was calculated from the receiver operating characteristic (ROC) curve. Finally, the prognostic value of HCIPS was validated through survival analysis, stratified analyses, and nomograms. Results HCIPS was composed of albumin (ALB) and thrombin time (TT), with a cut-off value of 0.64. There were 56 patients with HCIPS < 0.64 and 95 patients with HCIPS greater than or equal to 0.64, patients with low HCIPS were significantly related to shorter progression-free survival (PFS) (13.10 months vs. 1.63 months, P < 0.001) and overall survival (OS) (14.83 months vs. 25.43 months, P < 0.001). HCIPS has also been found to be an independent prognostic factor in this study. In addition, the stratified analysis found a significant correlation between low HCIPS and shorter OS in patients with tumor size greater than or equal to 5 cm (P of interaction = 0.032). The C-index and 95% CI of the nomograms for PFS and OS were 0.730 (0.680-0.779) and 0.758 (0.711-0.804), respectively. Conclusions As a new score established based on HCC patients receiving ICIs, HCIPS was significantly correlated with clinical outcomes in patients with ICIs and might serve as a new biomarker to predict HCC patients who cloud benefit from ICIs. Keywords: Prognosis score, Hepatocellular carcinoma, Immune checkpoint inhibitors, Clinical outcomes, Non-invasive biomarkers
PDF
