The stability and sensitivity of two- and three-dimensional global modes developing on steady spanwise-homogeneous laminar separated flows around NACA 4412 swept wings are numerically investigated ...for different Reynolds numbers ${\textit {Re}}$ and angles of attack $\alpha$. The wake dynamics is driven by the two-dimensional von Kármán mode whose emergence threshold in the $\alpha \unicode{x2013}{\textit {Re}}$ plane is computed with that of the three-dimensional centrifugal mode. At the critical Reynolds number, the Strouhal number, the streamwise wavenumber of the von Kármán mode and the spanwise wavenumber of the leading three-dimensional centrifugal mode scale as a power law of $\alpha$. The introduction of a sweep angle attenuates the growth of all unstable modes and entails a Doppler effect in the leading modes’ dynamics and a shift towards non-zero frequencies of the three-dimensional centrifugal modes. These are found to be non-dispersive as opposed to the von Kármán modes. The sensitivity of the leading global modes is investigated in the vicinity of the critical conditions through adjoint-based methods. The growth-rate sensitivity map displays a region on the suction side of the wing, wherein a streamwise-oriented force has a net stabilising effect, comparable to what could have been obtained inside the recirculation bubble. In agreement with the predictions of the sensitivity analysis, a spanwise-homogeneous force suppresses the Hopf bifurcation and stabilises the entire branch of von Kármán modes. In the limit of small amplitudes, passive control via spanwise-wavy forcing produces a stabilising effect similar to that of a spanwise-homogeneous control and is more effective than localised spherical forces.
The radiation therapy quality assurance of clinical trials is internationally recognized as a key factor to control the quality of radiotherapy for its impact on clinical trial's goals. Quality ...assessment may be performed at different levels and by different means, which are now quite standardized. The optimal radiation therapy quality assurance of clinical trials trade-off to maintain accrual rates, radiotherapy quality and optimize clinical trial research processes is yet to be defined. This article addresses current definitions, processes, limitations and directions.
Le processus d’assurance qualité des essais cliniques en radiothérapie est internationalement reconnu comme un facteur clé pour contrôler la qualité de la radiothérapie et contrôler l’impact de la qualité de la radiothérapie sur les objectifs des essais cliniques. L’évaluation de la qualité peut être effectuée à différents niveaux et par différents moyens, qui sont désormais assez standardisés. Le compromis optimal entre le choix des procédures d’évaluation de la qualité (questionnaires de faisabilité, accréditation des centres avant inclusions, assurance qualité des patients de l’essai) de la radiothérapie et le maintien de la dynamique d’inclusions reste à définir. Cet article aborde les définitions, les processus, les limites et les orientations actuelles.
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•Human land use affects blood parasite diversity, prevalence and intra-host parasite interactions.•Plasmodium and Haemoproteus parasites are more abundant in degraded ...habitats.•Leucocytozoon parasites are preferentially found in natural forested areas.•We found large variations in parasite diversity and prevalence among bird species.
Tropical forests are experiencing increasing impacts from a multitude of anthropogenic activities such as logging and conversion to agricultural use. These perturbations are expected to have strong impacts on ecological interactions and on the transmission dynamics of infectious diseases. To date, no clear picture of the effects of deforestation on vector-borne disease transmission has emerged. This is associated with the challenge of studying complex systems where many vertebrate hosts and vectors co-exist. To overcome this problem, we focused on an innately simplified system – a small oceanic island (São Tomé, Gulf of Guinea). We analyzed the impacts of human land-use on host-parasite interactions by sampling the bird community (1735 samples from 30 species) in natural and anthropogenic land use at different elevations, and screened individuals for haemosporidian parasites from three genera (Plasmodium, Haemoproteus, Leucocytozoon). Overall, Plasmodium had the highest richness but the lowest prevalence, while Leucocytozoon diversity was the lowest despite having the highest prevalence. Interestingly, co-infections (i.e. intra-host diversity) involved primarily Leucocytozoon lineages (95%). We also found marked differences between bird species and habitats. Some bird species showed low prevalence but harbored high diversity of parasites, while others showed high prevalence but were infected with fewer lineages. These infection dynamics are most likely driven by host specificity of parasites and intrinsic characteristics of hosts. In addition, Plasmodium was more abundant in disturbed habitats and at lower elevations, while Leucocytozoon was more prevalent in forest areas and at higher elevations. These results likely reflect the ecological requirements of their vectors: mosquitoes and black flies, respectively.
Highly compacted sand–bentonite mixtures are often considered as possible engineered barriers in deep high-level radioactive waste disposals. In situ, the saturation of these barriers from their ...initially unsaturated state is a complex hydro-mechanical coupled process in which temperature effects also play a role. The key parameter of this process is the unsaturated hydraulic conductivity of the barrier. In this paper, isothermal infiltration experiments were conducted to determine the unsaturated hydraulic conductivity according to the instantaneous profile method. To do so, total suction changes were monitored at different locations along the soil specimen by using resistive relative humidity probes. Three constant-volume infiltration tests were conducted showing, unexpectedly, a decrease of the hydraulic conductivity during infiltration. One test performed under free-swell conditions showed the opposite and standard trend. These observations were interpreted in terms of microstructure changes during wetting, both under constant-volume and free-swell conditions.
In a previous work, a PENELOPE Monte Carlo model of a Cyberknife system equipped with fixed collimator was developed and validated for in-field dose evaluation. The aim of this work is to extend it ...to evaluate peripheral doses and to determine the precision of the treatment planning system (TPS) Multiplan in evaluating the off-axis doses. The Cyberknife
head model was completed with surrounding components based on manufacturer drawings. The contribution of the different head parts on the out-of-field dose was studied. To model the attenuation and the modification of particle energy caused by components not modelled, the photon transport was modified in one of the added components. The model was iteratively adjusted to fit dose profiles measured with EBT3 films and an ionization chamber for several collimator sizes. Finally, dose profiles were calculated using the two Multiplan TPS algorithms and were compared to our simulations. The contributions to out-of-field dose were identified as scattered radiation from the phantom and head leakage and scatter originating at the secondary collimator level. Particle transport in the additional pieces was modified to model this radiation. The maximum differences between simulated and measured doses are of 20.4%. Regarding the detector responses away from axis, EBT3 films and the Farmer chamber give similar response (less than 20% difference). The TPS Monte Carlo algorithm underestimates the doses away from axis more importantly for the smaller field sizes (up to 98%). Besides, RayTracing simplifies peripheral dose to a constant value with no inclusion of particle transport. A Monte Carlo model of a Cyberknife system for the determination of out-of-field doses up to 14 cm off-axis was successfully developed and validated for different depths and field sizes in comparison with measurements. This study also confirms that TPS algorithms do not model peripheral dose properly.
Critical to the mitigation of parasitic vector-borne diseases is the development of accurate spatial predictions that integrate environmental conditions conducive to pathogen proliferation. Species ...of Plasmodium and Trypanosoma readily infect humans, and are also common in birds. Here, we develop predictive spatial models for the prevalence of these blood parasites in the olive sunbird (Cyanomitra olivacea). Since this species exhibits high natural parasite prevalence and occupies diverse habitats in tropical Africa, it represents a distinctive ecological model system for studying vector-borne pathogens. We used PCR and microscopy to screen for haematozoa from 28 sites in Central and West Africa. Species distribution models were constructed to associate ground-based and remotely sensed environmental variables with parasite presence. We then used machine-learning algorithm models to identify relationships between parasite prevalence and environmental predictors. Finally, predictive maps were generated by projecting model outputs to geographically unsampled areas. Results indicate that for Plasmodium spp., the maximum temperature of the warmest month was most important in predicting prevalence. For Trypanosoma spp., seasonal canopy moisture variability was the most important predictor. The models presented here visualize gradients of disease prevalence, identify pathogen hotspots and will be instrumental in studying the effects of ecological change on these and other pathogens.
The restoration of CD4+ T cells, especially T-helper type 17 (Th17) cells, remains incomplete in the gut mucosa of most human immunodeficiency virus type 1 (HIV-1)-infected individuals despite ...sustained antiretroviral therapy (ART). Herein, we report an increase in the absolute number of CXCR3+ T cells in the duodenal mucosa during ART. The frequencies of Th1 and CXCR3+ CD8+ T cells were increased and negatively correlated with CCL20 and CCL25 expression in the mucosa. In ex vivo analyses, we showed that interferon γ, the main cytokine produced by Th1 and effector CD8+ T cells, downregulates the expression of CCL20 and CCL25 by small intestine enterocytes, while it increases the expression of CXCL9/10/11, the ligands of CXCR3. Interleukin 18, a pro-Th1 cytokine produced by enterocytes, also contributes to the downregulation of CCL20 expression and increases interferon γ production by Th1 cells. This could perpetuate an amplification loop for CXCR3-driven Th1 and effector CD8+ T cells recruitment to the gut, while impairing Th17 cells homing through the CCR6-CCL20 axis in treated HIV-1-infected individuals.
The steadily increasing luminosity of the LHC requires an upgrade with high-rate and high-resolution detector technology for the inner end cap of the ATLAS muon spectrometer: the New Small Wheels ...(NSW). In order to achieve the goal of precision tracking at a hit rate of about 15 kHz/cm2 at the inner radius of the NSW, large area Micromegas quadruplets with 100µm spatial resolution per plane have been produced. IRFU, from the CEA research center of Saclay, is responsible for the production and validation of LM1 Micromegas modules. The construction, production, qualification and validation of the largest Micromegas detectors ever built are reported here. Performance results under cosmic muon characterization will also be discussed.
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