Une histoire de ≪ chouchou Berthier, S.; Bonnotte, B.; Ghinringhelli, F. ...
La Revue de médecine interne (Paris),
6/2002, Letnik:
23
Journal Article, Conference Proceeding
Une maladie peut en cacher une autre Nicolas, B.; Audia, S.; Couturier, M. ...
La revue de medecine interne,
December 2012, 2012-12-00, Letnik:
33
Journal Article
Une hypoglycémie d’étiologie inhabituelle Antier, N.; Lorcerie, B.; Berthier, S. ...
La revue de medecine interne,
December 2012, 2012-12-00, Letnik:
33
Journal Article
The use of warfarin sodium for treating venous thromboembolism in patients with cancer is associated with a significant risk of recurrence and bleeding. The use of low-molecular-weight heparin sodium ...for secondary prevention of venous thromboembolism in cancer patients may reduce the complication rate.
To determine whether a fixed dose of subcutaneous low-molecular-weight heparin is superior to oral warfarin for the secondary prophylaxis of venous thromboembolism in patients with cancer and venous thromboembolism.
In a randomized, open-label multicenter trial performed between April 1995 and March 1999, we compared subcutaneous enoxaparin sodium (1.5 mg/kg once a day) with warfarin given for 3 months in 146 patients with venous thromboembolism and cancer.
A combined outcome event defined as major bleeding or recurrent venous thromboembolism within 3 months.
Of the 71 evaluable patients assigned to receive warfarin, 15 (21.1%; 95% confidence interval CI, 12.3%-32.4%) experienced one major outcome event compared with 7 (10.5%) of the 67 evaluable patients assigned to receive enoxaparin (95% CI, 4.3%-20.3%; P =.09). There were 6 deaths owing to hemorrhage in the warfarin group compared with none in the enoxaparin group. In the warfarin group, 17 patients (22.7%) died (95% CI, 13.8%-33.8%) compared with 8 (11.3%) in the enoxaparin group (95% CI, 5.0%-21.0%; P =.07). No difference was observed regarding the progression of the underlying cancer or cancer-related death.
These results confirm that warfarin is associated with a high bleeding rate in patients with venous thromboembolism and cancer. Prolonged treatment with low-molecular-weight heparin may be as effective as oral anticoagulants and may be safer in these cancer patients.
Les dessous CHICS du méthotrexate Couturier, M.; Nicolas, B.; Audia, S. ...
La revue de medecine interne,
December 2012, 2012-12-00, Letnik:
33
Journal Article
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