Herbacetin
In article number 2101485, Xiaoping Zhao, Yi Wang, and co‐workers describe that herbacetin (HBT) derived from traditional Chinese medicine Rhodiola rosea (known as “golden root” in Europe) ...is identified as a novel SGK1 inhibitor to significantly alleviate myocardial hypertrophy, which brings dawn to patients with heart failure as well as other SGK1‐driven diseases.
Topiramate has been used in patients with brain tumors who develop epilepsy. In our previous research we found topiramate could inhibit tumor metastases of Lewis lung carcinoma in C57BL/6 mice. In ...this study we aimed to assess the antimetastatic activity of topiramate and determine its mechanism of action. After confirming the effects of topiramate on Lewis lung carcinoma in C57BL/6 mice, we assessed the mRNA expression of carbonic anhydrases II and IX, and the vascular endothelial growth factor (VEGF) distribution in tumor tissue. We studied the role of topiramate on primary angiogenesis using a chicken embryo chorioallantoic membrane angiogenesis model, and analyzed the protein profile of serum from mice treated with or without topiramate by two-dimensional electrophoresis. We found that topiramate significantly reduced the primary tumor growth (
P
<
0.05) and the degree of damage to the lung alveoli caused by metastatic tumor deposits. The two-dimensional electrophoresis revealed changes that occurred with topiramate treatment and four down-regulated protein spots were clearly identified as tropomyosin, osteopontin, transthyretin, and serum amyloid A-1. The mRNA and protein expression of serum amyloid A-1, osteopontin and its receptor, integrin α
vβ
3 in tumor tissue were reconfirmed. The results suggest that topiramate has antitumor and antimetastatic effects on Lewis lung carcinoma. Its mechanism of action may be related to its inhibition of angiogenesis by down-regulation of osteopontin, VEGF and carbonic anhydrase II.
In order to prepare a new type of graphene modified composite anion exchange membranes (AEMs) with good dispersity, high conductivity and low permeability, quaternized polymer brush-functionalized ...graphenes (QPbGs) were successfully synthesized from graphene oxide (GO) by a hydrothermal process and "grafting from" method based on a reversible addition fragmentation chain transfer polymerization. By incorporating different amounts of QPbGs into a quaternized polysulfone (QPSU) matrix, the obtained composite membranes with dispersed QPbGs showed good thermal stability, oxide stability and mechanical properties. As shown in transmission electron microscope images, the concentration of ionic clusters with uniform distribution of membranes increased when the content of QPbGs was below 1 wt%, illustrating that the quaternary ammonium groups in polymer brushes may provide more ionic pathways. The bicarbonate conductivity of composite membranes increased with increasing content of QPbGs and showed the highest conductivity of 0.056 S cm
−1
at 80 °C. The other properties including ion exchange capacity, water uptake, swelling ratios, methanol permeability and alkaline resistance of membranes were all improved with increasing amount of QPbGs fillers. Our study showed that AEMs with enhanced performance can be achieved by incorporating an appropriate content of QPbGs into the QPSU matrix.
Novel quaternized polymer brush-functionalized graphenes (QPbGs) were synthesized and a series of composite anion exchange membranes for alkaline fuel cells were fabricated by incorporating different amounts of QPbGs into quaternized polysulfone.
PDF
