Morality and empathy are both crucial in building human society. Yet the relationship between them has been merely explored. The present study revealed how the morality influenced empathy for pain by ...comparing the ERPs elicited by pictures showing the targets' in pain primed by different moral information about the targets. We found that when the target was a moral one or a neutral one, the painful pictures elicited significantly larger amplitude in N2 than the non-painful pictures, but when the target was an immoral one, the difference between the amplitudes of N2 component elicited by painful and non-painful pictures became insignificant. We proposed that this effect was induced by the decreased affective arousal when observing an immoral person in pain. The reduced neural response towards the immoral one's pain can keep us alert when we face the potentially dangerous people thereby increasing our chance of survival. SLORTEA results showed the source of this difference in N2 localized in the ventral medial prefrontal cortex (vmPFC) and the rostral anterior cingulate cortex (rACC) areas.
•Brain organizations of facial expression recognition support the constructionist hypothesis.•Common brain activation and connectivity distributions are shared by different discrete/dimensional ...facial expressions.•The amygdala-centered 'core' affect system are connected to distributed networks.•The brain organizations of facial expression recognition are flexibly asymmetrical.
Discrimination of facial expressions is an elementary function of the human brain. While the way emotions are represented in the brain has long been debated, common and specific neural representations in recognition of facial expressions are also complicated. To examine brain organizations and asymmetry on discrete and dimensional facial emotions, we conducted an activation likelihood estimation meta-analysis and meta-analytic connectivity modelling on 141 studies with a total of 3138 participants. We found consistent engagement of the amygdala and a common set of brain networks across discrete and dimensional emotions. The left-hemisphere dominance of the amygdala and AI across categories of facial expression, but category-specific lateralization of the vmPFC, suggesting a flexibly asymmetrical neural representations of facial expression recognition. These results converge to characteristic activation and connectivity patterns across discrete and dimensional emotion categories in recognition of facial expressions. Our findings provide the first quantitatively meta-analytic brain network-based evidence supportive of the psychological constructionist hypothesis in facial expression recognition.
Motivated dishonesty is a typical social behavior varying from person to person. Resting-state fMRI (rsfMRI) is capable of identifying unique patterns from functional connectivity (FC) between brain ...regions. Recent work has built a link between brain networks in resting state to dishonesty in Western participants. To determine and reproduce the relevant neural patterns and build an interpretable model to predict dishonesty, we analyzed two conceptually similar datasets containing rsfMRI data with different dishonesty tasks. Both tasks implemented the information-passing paradigm, in which monetary rewards were employed to induce dishonesty. We applied connectome-based predictive modeling (CPM) to build a model among FC within and between four social brain networks (reward, self-referential, moral, and cognitive control). The CPM analysis indicated that FCs of social brain networks are predictive of dishonesty rate, especially FCs within reward network, and between self-referential and cognitive control networks. Our study offers an conceptual replication with integrated model to predict dishonesty with rsfMRI, and the results suggest that frequent motivated dishonest decisions may require the higher engagement of social brain regions.
GNE myopathy is a heterogeneous group of ultrarare neuromuscular disorders caused by mutations in the GNE gene. An estimated prevalence of 1~21/1,000,000 leads to a deficiency of data and a lack of ...availability of samples to conduct clinical research on this neuromuscular disorder. Although GNE, which is the mutated gene responsible for the disease, is well known as the key enzyme in the biosynthesis pathway of sialic acid, the clinicopathological‐genetic spectrum of GNE mutant patients is still unclear and expanding. This study presents ten unrelated patients with GNE myopathy, discovering five novel missense mutations. Clinical, electrophysiological, imaging, pathological and genetic data are presented in a retrospective manner. Interestingly, several patients in the cohort were found to have peripheral neuropathy and inflammatory cell infiltration in muscle biopsies, which have seldom been reported. This study, conducted by a neuromuscular centre in China, is the first attempt to highlight these abnormal clinicopathological features and associate them with genetic mutations in GNE myopathy.
Moral contagion is a phenomenon in which individuals or objects take on the moral essence of the people who are associated with them. Previous studies have found that individuals value objects ...associated with moral and likable people more than those associated with immoral and dislikable people. However, the neural mechanisms underlying this “moral contagion effect” have not yet been explored. In the present study, we combined a novel “Second‐hand Goods Pricing” paradigm with functional magnetic resonance imaging to (a) confirm the existence of the moral contagion effect on the hypothetical economic valuation of objects and (b) determine the neural substrates underlying it. Participants were shown second‐hand goods, information regarding the moral valence of the previous owner, and an initial price assigned to the object by computer. The participants were then asked to adjust the initial price to one they deemed most reasonable. Behaviorally, we found a significant devaluation effect for immoral owners and a weaker reverse effect for moral owners. Imaging data showed that the devaluation effect was primarily driven by neural responses in the dorsal striatum (mainly the caudate nucleus) that were triggered by high initial prices assigned to the “contaminated” objects. Dynamic causal modeling revealed that the high initial price assigned to “contaminated” objects led to increased effective connectivity from the caudate nucleus to the ventromedial prefrontal cortex—the brain area that integrates values during decision making.
To optimize our decisions, we may change our mind by utilizing social information. Here, we examined how changes of mind were modulated by Social Misalignment Sensitivity (SMS), egocentric tendency, ...and decision preferences in a decision-making paradigm including both risk and social information. Combining functional magnetic resonance imaging with computational modeling, we showed that both SMS and egocentric tendency modulated changes of mind under the influence of social information. While SMS was represented in the dorsal anterior cingulate cortex (dACC) and superior parietal gyrus (SPG) in the socially aligned situation, a distributed brain network was activated in the misaligned condition, including not only the dACC and SPG but also superior frontal gyrus and precuneus. These results suggest that SMS is related to a monitoring brain system, the scope of which varies according to the level of misalignment with social majority. The dorsolateral prefrontal cortex selectively interacted with SMS among the participants with a low switching threshold, indicating that its regulation on SMS may be sensitive to inter-individual variation. Our findings highlight the predominant roles of SMS and the prefrontal control system towards changes of mind under social influence.
Dermatomyositis, polymyositis and immune-mediated necrotising myopathy are major forms of idiopathic inflammatory myopathy. We review here recent developments in understanding the pathology and ...pathogenesis of these diseases, and characterisation of autoantibody biomarkers. Dermatomyositis is traditionally considered to be due to a complement-mediated microangiopathy but the factors responsible for complement activation remain uncertain. Recent studies have emphasised the importance of the type I interferon pathway in the pathogenesis of the disease and have identified autoantibodies with specificities for different clinical subgroups of patients. Polymyositis is characterised by a cytotoxic T cell response targeting as yet unidentified muscle antigens presented by MHC Class I molecules, and can occur in isolation but is more often part of a multi-systemic overlap syndrome. The immune-mediated necrotising myopathies are heterogeneous and are distinguished from polymyositis by the sparseness of inflammatory infiltrates and recognition of an association with specific autoantibodies such as anti-SRP and anti-HMGCR in many cases. This article is part of a Special Issue entitled: Neuromuscular Diseases: Pathology and Molecular Pathogenesis.
•Complement-dependent microangiopathy and activation of the type I IFN pathway play major roles in DM.•CD8+ T cell-mediated cytotoxicity is the cause of muscle injury in PM.•IMNM associated with anti-SRP antibody is complement-mediated.•IMNM associated with anti-HMGCR antibody can occur both in statin-treated and statin-naïve patients.
Resource scarcity challenges individuals' willingness to share limited resources with other people. Still, lots of field studies and laboratory experiments have shown that sharing behaviors do not ...disappear under scarcity. Rather, some individuals are willing to share their scarce resources with others in a similar way as when the resource is abundant, which is crucial for the maintenance and development of human society. Here, we designed a novel paradigm in which subjects decided whether (and how much) to share an amount of "relieving resources" for counteracting unpleasant noises, which mimics real-life situations that people cost their own resources to help others escape from adversity. Overall, the robustness of resource sharing under scarcity was positively correlated with individual level of the cognitive component of empathy across two independent experiments. Resource insufficiency modulated the activations of several brain regions (including the TPJ, mPFC, and PCC) as well as the functional connection (from the rTPJ to the mPFC) within the mentalizing brain network, but the modulatory effect decreased as a function of cognitive empathy. We also applied the administration of oxytocin and found significant effects on sharing behavior among individuals with a higher level of cognitive empathy, but not their low-level counterparts. These findings highlight the importance of empathy to resource sharing under scarcity and explain the underlying neurobiological mechanisms.
Electrophysiological correlates of the processing facial expressions were investigated in subjects performing the rapid serial visual presentation (RSVP) task. The peak latencies of the event-related ...potential (ERP) components P1, vertex positive potential (VPP), and N170 were 165, 240, and 240 ms, respectively. The early anterior N100 and posterior P1 amplitudes elicited by fearful faces were larger than those elicited by happy or neutral faces, a finding which is consistent with the presence of a ‘negativity bias.’ The amplitude of the anterior VPP was larger when subjects were processing fearful and happy faces than when they were processing neutral faces; it was similar in response to fearful and happy faces. The late N300 and P300 not only distinguished emotional faces from neutral faces but also differentiated between fearful and happy expressions in lag2. The amplitudes of the N100, VPP, N170, N300, and P300 components and the latency of the P1 component were modulated by attentional resources. Deficient attentional resources resulted in decreased amplitude and increased latency of ERP components. In light of these results, we present a hypothetical model involving three stages of facial expression processing.
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