Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider ...functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the form of obesity can impact AMPK and whole-body metabolism, leading to complications such as type 2 diabetes and cancer risk. There is a lack of data regarding the nature and extent that nutrient status has on AMPK and metabolic-inflammation. However, emerging work elucidates to a direct role of individual nutrients on AMPK and metabolic-inflammation, as a possible means of modulating AMPK activity. The posit being to use such nutritional agents to re-configure metabolic-inflammation towards more oxidative phosphorylation and promote the resolution of inflammation. The complex paradigm will be discussed within the context of if/how dietary components, nutrients including fatty acids and non-nutrient food components, such as resveratrol, berberine, curcumin and the flavonoid genistein, modulate AMPK dependent processes relating to inflammation and metabolism.
Abstract
Recent developments in theoretical techniques have significantly improved the predictive power of density-functional-based calculations. In this review, we discuss how such advancements have ...enabled improved understanding of native point defects in GaN. We review the methodologies for the calculation of point defects, and discuss how techniques for overcoming the band-gap problem of density functional theory affect native defect calculations. In particular, we examine to what extent calculations performed with semilocal functionals (such as the generalized gradient approximation), combined with correction schemes, can produce accurate results. The properties of vacancy, interstitial, and antisite defects in GaN are described, as well as their interaction with common impurities. We also connect the first-principles results to experimental observations, and discuss how native defects and their complexes impact the performance of nitride devices. Overall, we find that lower-cost functionals, such as the generalized gradient approximation, combined with band-edge correction schemes can produce results that are qualitatively correct. However, important physics may be missed in some important cases, particularly for optical transitions and when carrier localization occurs.
Worldwide obesity rates have reached epidemic proportions and significantly contribute to the growing prevalence of metabolic diseases. Chronic low-grade inflammation, a hallmark of obesity, involves ...immune cell infiltration into expanding adipose tissue. In turn, obesity-associated inflammation can lead to complications in other metabolic tissues (e.g., liver, skeletal muscle, pancreas) through lipotoxicity and inflammatory signaling networks. Importantly, although numerous signaling pathways are known to integrate metabolic and inflammatory processes, the nucleotide-binding and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome is now noted to be a key regulator of metabolic inflammation. The NLRP3 inflammasome can be influenced by various metabolites, including fatty acids. Specifically, although saturated fatty acids may promote NLRP3 inflammasome activation, monounsaturated fatty acids and polyunsaturated fatty acids have recently been shown to impede NLRP3 activity. Therefore, the NLRP3 inflammasome and associated metabolic inflammation have key roles in the relationships among fatty acids, metabolites, and metabolic disease. This review focuses on the ability of fatty acids to influence inflammation and the NLRP3 inflammasome across numerous metabolic tissues in the body. In addition, we explore some perspectives for the future, wherein recent work in the immunology field clearly demonstrates that metabolic reprogramming defines immune cell functionality. Although there is a paucity of information about how diet and fatty acids modulate this process, it is possible that this will open up a new avenue of research relating to nutrient-sensitive metabolic inflammation.
A critical, long‐standing problem in substorm research is identification of the sequence of events leading to substorm auroral onset. Based on event and statistical analysis of THEMIS all‐sky imager ...data, we show that there is a distinct and repeatable sequence of events leading to onset, the sequence having similarities to and important differences from previous ideas. The sequence is initiated by a poleward boundary intensification (PBI) and followed by a north‐south (N‐S) arc moving equatorward toward the onset latitude. Because of the linkage of fast magnetotail flows to PBIs and to N‐S auroras, the results indicate that onset is preceded by enhanced earthward plasma flows associated with enhanced reconnection near the pre‐existing open‐closed field line boundary. The flows carry new plasma from the open field line region to the plasma sheet. The auroral observations indicate that Earthward‐transport of the new plasma leads to a near‐Earth instability and auroral breakup ∼5.5 min after PBI formation. Our observations also indicate the importance of region 2 magnetosphere‐ionosphere electrodynamic coupling, which may play an important role in the motion of pre‐onset auroral forms and determining the local times of onsets. Furthermore, we find motion of the pre‐onset auroral forms around the Harang reversal and along the growth phase arc, reflecting a well‐developed region 2 current system within the duskside convection cell, and also a high probability of diffuse‐appearing aurora occurrence near the onset latitude, indicating high plasma pressure along these inner plasma sheet field lines, which would drive large region 2 currents.
Identifying the Driver of Pulsating Aurora Nishimura, Y; Bortnik, J; Li, W ...
Science (American Association for the Advancement of Science),
10/2010, Letnik:
330, Številka:
6000
Journal Article
Recenzirano
Pulsating aurora, a spectacular emission that appears as blinking of the upper atmosphere in the polar regions, is known to be excited by modulated, downward-streaming electrons. Despite its ...distinctive feature, identifying the driver of the electron precipitation has been a long-standing problem. Using coordinated satellite and ground-based all-sky imager observations from the THEMIS mission, we provide direct evidence that a naturally occurring electromagnetic wave, lower-band chorus, can drive pulsating aurora. Because the waves at a given equatorial location in space correlate with a single pulsating auroral patch in the upper atmosphere, our findings can also be used to constrain magnetic field models with much higher accuracy than has previously been possible.
The difficulty in obtaining as well as maintaining weight loss, together with the impairment of metabolic control in conditions like diabetes and cardiovascular disease, may represent pathological ...situations of inadequate neural communication between the brain and peripheral organs and tissues. Innervation of adipose tissues by peripheral nerves provides a means of communication between the master metabolic regulator in the brain (chiefly the hypothalamus), and energy-expending and energy-storing cells in the body (primarily adipocytes). Although chemical and surgical denervation studies have clearly demonstrated how crucial adipose tissue neural innervation is for maintaining proper metabolic health, we have uncovered that adipose tissue becomes neuropathic (ie: reduction in neurites) in various conditions of metabolic dysregulation. Here, utilizing both human and mouse adipose tissues, we present evidence of adipose tissue neuropathy, or loss of proper innervation, under pathophysiological conditions such as obesity, diabetes, and aging, all of which are concomitant with insult to the adipose organ as well as metabolic dysfunction. Neuropathy is indicated by loss of nerve fiber protein expression, reduction in synaptic markers, and lower neurotrophic factor expression in adipose tissue. Aging-related adipose neuropathy particularly results in loss of innervation around the tissue vasculature, which cannot be reversed by exercise. Together with indications of neuropathy in muscle and bone, these findings underscore that peripheral neuropathy is not restricted to classic tissues like the skin of distal extremities, and that loss of innervation to adipose may trigger or exacerbate metabolic diseases. In addition, we have demonstrated stimulation of adipose tissue neural plasticity with cold exposure, which may ameliorate adipose neuropathy and be a potential therapeutic option to re-innervate adipose and restore metabolic health.
Recent ionospheric measurements suggest polar cap flow channels often trigger nightside auroral brightening. However, measurements were limited to the ionosphere, and it was not understood if such ...flow channels can exist in the lobe and can trigger magnetotail reconnection in a localized cross‐tail extent. We examined if localized flow channels can form self‐consistently in a global MHD regime, and if so, how such flow channels originate and relate to localized magnetotail reconnection. We show that lobe convection became nonuniform with azimuthally narrow flow channels (enhanced dawn‐dusk electric fields) of ~3 RE cross‐tail width. The flow channels propagated from the dayside toward the plasma sheet as an interplanetary magnetic field (IMF) discontinuity swept tailward. The plasma sheet around the lobe flow channels became thinner with a similar cross‐tail extent and then localized reconnection occurred. These results suggest that localized flow channels can propagate tailward across the lobe and drive localized magnetotail reconnection, that the cross‐tail width of reconnection and resulting plasma sheet flow channels and dipolarization fronts are related to the width of inflow from the lobe, and that IMF discontinuities drive lobe flow channels.
Key Points
Lobe convection became nonuniform with azimuthally narrow flow channels
Lobe flow channels propagate tailward and drive localized magnetotail reconnection
The cross‐tail width of reconnection and BBFs is related to the width of inflow from the lobe
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