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•The ROS of venlafaxine and O-desmethylvenlafaxine were analyzed in liver tissue in the presence and absence of microplastic.•The enantiomeric bioaccumulation and metabolism of ...venlafaxine in the presence and absence of microplastic were studied.•R-venlafaxine and its metabolite R-O-desmethylvenlafaxine were biotransformed preferentially.•The distribution of venlafaxine and O-desmethylvenlafaxine in liver subcellular changed when co-exposure to microplastic.
In present study, we investigated the enantioselective behaviors of the chiral antidepressant venlafaxine and its metabolite O-desmethylvenlafaxine in loach Misgurnus anguillicaudatus (M. anguillicaudatus), as well as effects of microplastic on toxicity, distribution and metabolism through a 40-day co-exposure. The contents of SOD and MDA in loach liver elevated when the loach was exposed to venlafaxine and O-desmethylvenlafaxine. Moreover, co-exposure with microplastic might lead to more adverse effect against loach. The distribution of venlafaxine and O-desmethylvenlafaxine were both detected in loach tissues and liver subcellular. The concentrations of venlafaxine and O-desmethylvenlafaxine were lower in water in microplastic-present treatment. Whilst, more contaminants were accumulated in liver through the “vehicle” (microplastic). Enantioselective behavior of venlafaxine and O-desmethylvenlafaxine occurred with R-enantiomers being preferentially degraded. With microplastic present, the bioaccumulation factor (BAF) of venlafaxine and O-desmethylvenlafaxine in loach tissue amplified more than 10 times. In liver subcellular structure, microplastic may help to transport more compounds into subtle areas and postpone the contaminants metabolism in organisms. The present study for the first time gained an insight into the potential ecological effects and environmental behaviors of combined pollutions of chiral pharmaceuticals and microplastic, which could supply important information for environment risk assessment of concurrent organic pollutants and microplastic.
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•Methamphetamine could be adsorbed by microplastics in water.•The toxicity of methamphetamine was aggravated significantly by microplastics.•Microplastics increase the filter-feeding ...fate of snail.•Microplastics increase the enrichment of R-methamphetamine in aquatic organism.•Showing the bio-effect of microplastics and methamphetamine through aquatic food chain.
The biological impacts of microplastics on many organisms have been well documented. However, the combined effects of microplastics and chiral chemicals on the aquatic food chain are less clear. In the present study, the enantioselective environmental behaviors of methamphetamine co-exposed with microplastics through an aquatic food chain (from Chlorella pyrenoidosa to Cipangopaludian cathayensis) have been investigated in a laboratory environment. It was found that the acute toxicity of methamphetamine against these two species was significantly increased in the presence of microplastics: Chlorella pyrenoidosa showed an EC50 shift from 0.77 to 0.32 mg L−1, while cipangopaludian cathayensis showed an LC50 shift from 4.15 to 1.48 mg L−1, upon the addition of microplastics as a co-contaminant with methamphetamine. Upon exposure to methamphetamine and microplastics, the oxidative damage of algae (19.9 to 36.8 nmol mgprot−1), apoptosis (increase about 2.17 times) and filtration rate (41.2 to 65.4 mL h−1) of snails were observably higher when compared to exposure to methamphetamine alone. After ingestion and accumulation of microplastics, the enantioselectivity, BCFs, BMFs, and distribution of methamphetamine were significantly altered. These results provide evidence that the co-occurrence of microplastics and the chiral drug methamphetamine may increase the burden on aquatic species, with potential further impacts throughout aquatic food chain.
•33 PPCPs were monitored in Beiyun River and tributaries in summer and winter in 2015.•Caffeine, acetaminophen and erythromycin were the most abundant compounds.•Antibiotics had higher concentration ...in winter, but only accounted 28% of the total.•The burden of PhACs in 2015 in Beiyun River basin reduced by 37% of that in 2013.•CBZ level changed little and may exert sustained risks on aquatic environment.
Pharmaceutically active compounds (PhACs) as an important group of “emerging contaminants” (ECs), have been highlighted and received global attentions in last decade. China has tremendous consumption of PhACs and the most pharmaceutical manufacturers worldwide. In this study, 33 PhACs (19 antibiotics included) were monitored in the Beiyun River basin in Beijing, China. The seasonal occurrence, temporal-spatial distribution and potential source were investigated. The total levels were about 2μgL−1. Non-antibiotics were more frequently detected. The highest median concentrations were observed for caffeine (558ngL−1) and erythromycin (319ngL−1). Acetaminophen, erythromycin, diclofenac and N,N-diethyl-meta-toluamide showed highly significant seasonal variation, while caffeine, carbamazepine, metoprolol and most sulfonamides were more stable. The burden was most heavy in Qing River in both seasons (up to 4μgL−1). Antibiotics from veterinary use accounted for minor contribution in this region. The characteristics and trends were overviewed by comparing with our previous survey. The total level of 15 PhACs dropped significantly by 37% on average from 2013 to 2015. The proportion of caffeine, once a major component in 2013, reduced from 77% to 47%. The burden of these ECs in surface water of Beijing is remarkably reduced, suggesting the overall situation has been improving.
•First study on enantiomeric occurrence of chiral drugs and metabolites in surface water in China.•NODDV and α-hydroxymetoprolol were for the first time confirmed in domestic water.•The ...transformation products contributed to 60% of the total load of 11 compounds.•TPs could be transported substantial distances along the river with limited attenuation.•R-venlafaxine was more readily biotransformed than the S-form.
The present work aimed to discuss the enantiomeric occurrence of chiral pharmaceuticals including 5 parent compounds (PCs) metoprolol, propranolol, atenolol, venlafaxine and fluoxetine as well as 6 of their transformation products (TPs) in surface water in Beijing. Among which, 9 out of 11 were detected during the two sampling campaigns with N-O-Didesmethylvenlafaxine (NODDV) and α-hydroxymetoprolol confirmed in the catchment for the first time. Metoprolol acid (MTPA) was the most abundant up to 1508 ng L−1, followed by metoprolol and O-desmethylvenlafaxine (ODV). Most compounds showed 100% detection frequency or nearly, while norfluoxetine (the main metabolite of fluoxetine) and 4-hydroxypropranololone (one TP of propranolol) were not detected. Metoprolol (MTP) and venlafaxine (VFX) did not vary significantly between two sampling periods with mean concentrations of 280.7 and 22.9 ng L−1, respectively. Enantiomeric enrichment was observed for venlafaxine, metoprolol and NODDV, where R-venlafaxine was preferentially biotransformed than the S-form through O-desmethylation. Risk assessment indicated that fluoxetine and atenolol could pose harmful effects to aquatic organisms. This work provides enantiospecific profiles of pharmaceutically active compounds (PhACs), and extended the concept of applying the ratio of TPs vs. parent compound plus their enantiomeric traits for quantitative assessment of in situ biodegradation. Due to the considerable contribution by TPs (64% in present study) as well as the unexpected impacts from enantiomeric existence, the stereoselectivity of chiral pollutants during environmental process should be taken into account in future study. To the best of the authors’ knowledge, it is the first comprehensive evaluation of chiral pharmaceuticals and transformation products at enantiomeric level in aquatic environment in China, which would facilitate better understanding of their environmental fate.
Persistent organic pollutants (POPs) and endocrine disrupting compounds (EDCs) are almost ubiquitous in synthetic and natural sources; however these contaminants adversely impact ecosystems and ...humans. Owing to their potential toxicity, concerns have been raised about the effects of POPs and EDCs on ecological and human health. Therefore, toxicity evaluation and mechanisms actions of these contaminants are of great interest. The nematode Caenorhabditis elegans (C. elegans), an excellent model animal for environmental toxicology research, has been used widely for toxicity studies of POPs or EDCs from the whole-animal level to the single-cell level. In this review, we have discussed the toxicity of specific POPs or EDCs after acute, chronic, and multigenerational exposure in C. elegans. We have also introduced a discussion of the toxicological mechanisms of these compounds in C. elegans, with respect to oxidative stress, cell apoptosis, and the insulin/IGF-1 signaling pathway. Finally, we raised considered the perspectives and challenges of the toxicity assessments, multigenerational toxicity, and toxicological mechanisms.
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•Discussion of POPs and EDCs toxicity to C. elegans following different exposures.•Introduction to mechanisms of toxicity of POPs and EDCs in C. elegans.•Various perspectives and challenges were raised.
Tetrabromobisphenol A (TBBPA) is a nonregulated brominated flame retardant with a high production volume, and it is applied in a wide variety of consumer products. TBBPA is ubiquitous in abiotic ...matrices, wildlife and humans around the world. This paper critically reviews the published scientific data concerning the disposition, metabolism or kinetics and toxicity of TBBPA in animals and humans. TBBPA is rapidly absorbed and widely distributed among tissues, and is excreted primarily in the feces. In rats, TBBPA and its metabolites have limited systemic bioavailability. TBBPA has been detected in human milk in the general population. It is available to both the developing fetus and the nursing pups following maternal exposure. It has been suggested that TBBPA causes acute toxicity, endocrine disruptor activity, immunotoxicity, neurotoxicity, nephrotoxicity, and hepatotoxicity in animals. Cell-based assays have shown that TBBPA can induce reactive oxygen species in a concentration-dependent manner, and it promotes the production of inflammatory factors such as TNF α, IL-6, and IL-8. Cells exposed to high levels of TBBPA exhibit seriously injured mitochondria and a dilated smooth endoplasmic reticulum. This review will enhance the understanding of the potential risks of TBBPA exposure to ecological and human health.
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•TBBPA and its metabolites have limited systemic bioavailability.•TBBPA is available to both the developing fetus and nursing pup following maternal exposure.•TBBPA can affect thyroid hormone homeostasis.•TBBPA can induce reactive oxygen species and promotes the production of inflammatory factors.
Tetrabromobisphenol A has limited systemic bioavailability and can induce acute toxicity, endocrine disruptor activity, immunotoxicity, neurotoxicity, nephrotoxicity, and hepatotoxicity in animals.
Twenty commonly used pharmaceuticals including eight chiral drugs were investigated in Dongting Lake, China. The contamination level was relatively low on a global scale. Twelve pharmaceuticals were ...identified. The most abundant compound was caffeine followed by diclofenac, DEET, mefenamic acid, fluoxetine, ibuprofen and carbamazepine with mean concentrations from 2.0 to 80.8ngL−1. Concentrations between East and West Dongting Lake showed spatial difference, with the West Dongting Lake less polluted. The relatively high ratio of caffeine versus carbamazepine (over 50) may indicate there was possible direct discharge of domestic wastewater into the lake. This is the first study presenting a survey allowing for comprehensive analysis of multiclass achiral and chiral pharmaceuticals including beta-blockers, antidepressants and anti-inflammatory drugs in freshwater lake. The enantiomeric compositions presented racemic to weakly enantioselective, with the highest enantiomeric fraction (EF) of 0.63 for fluoxetine. Meanwhile, venlafaxine was identified and evaluated the environment risk in surface water in China for the first time. The results of risk assessment suggested that fluoxetine, venlafaxine and diclofenac acid might pose a significant risk to aquatic organisms in Dongting Lake. The resulting data will be useful to enrich the research of emerging pollutants in freshwater lake and stereochemistry for environment investigations.
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•Venlafaxine was firstly identified and determined in surface water in China.•Caffeine was the predominant compound in Dongting Lake.•The total residue was relatively low, with West Dongting less polluted than East Dongting.•FLX, VLX and DIC may pose significant risks toward Dongting Lake.•The EF values of chiral drugs presented racemic to weakly enantioselective.
Microplastics (MPs) and halogenated organic pollutants coexist in ambient water and MPs tend to sorb organic pollutants from surrounding environments. Herein, a study on the sorption behavior of ...tetrabromobisphenol-A (TBBPA) onto four different MPs, namely, polyethylene (PE), polypropylene (PP), polystyrene (PS), and polyvinyl chloride (PVC) was carried out. Effects of MPs properties and environmental factors, including the type, surface charge and pore volume as well as the ionic strength (Ca2+) and humic acid (HA) on the sorption of TBBPA were discussed. Results showed that the sorption of TBBPA onto the MPs could reached an equilibrium within 24 h, and the sorption capacities decreased in the following order —PVC (101.85 mg kg-1) >PS (78.95 mg kg-1) >PP (58.57 mg kg-1) >PE (49.43 mg kg-1). Adsorption kinetics data fitted by intraparticle diffusion model revealed both surface sorption and intraparticle diffusion contributed, in the interfacial diffusion stage approximately 11–29% of TBBPA slowly diffused onto the surface of the MPs, and finally, in the intraparticle diffusion stage. The increase of Ca2+ concentration could promote the sorption of TBBPA by PE, PP, and PS, but no significant alteration for PVC. For all the four MPs, HA was found to exert a negative effect on TBBPA sorption. The adsorption was mainly driven by hydrophobic partition and electrostatic interactions.
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•TBBPA sorption behaviors on four MPs (PE, PP, PS and PVC) were investigated.•Polyvinyl chloride (PVC) exhibited the highest sorption capacity for TBBPA.•TBBPA adsorption was mainly driven by hydrophobic and electrostatic interactions.•The sorption capacity of PVC was almost not affected by ionic strength of solution.
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