Omalizumab, which is a monoclonal anti-IgE antibody, has recently been used as an option in the treatment of inducible urticaria.
We describe the case of a 46-year-old woman who was referred to the ...Department of Allergy and Immunology of "Hospital Civil de Guadalajara, Dr. Juan I. Menchaca" due to a history of hives, body itching, changes in the color of the skin after exposure to water, and chest tightness after the intake of cold beverages; therefore, she used to limit her outdoor activities and personal hygiene. We conducted challenge tests with heat, soaked towels, treadmill walks, and dermographism; which were negative. The ice cube test was positive. To establish the speed of wheal formation, we established intervals of exposure to cold of one, three, five, and ten minutes; a positive result was obtained from the third minute. Due to the poor response to the drug treatment and to measures to avoid the cold, as well as to the poor quality of life, the high risk of anaphylaxis, and the advent of winter season, omalizumab was administered at monthly doses of 150 mg during the winter season. After the first dose, there were no reports of episodes of hives in areas exposed to cold; the ice cube test was negative before the second dose and in the following months, and the patient was able to ingest cold beverages and cold food. There were no adverse reactions that could be attributable to the use of omalizumab. Three years after the first dose, the patient was still asymptomatic.
The described case is one of the first cases of cold urticaria with risk of anaphylaxis with a positive response to omalizumab, which was reflected in symptom control and the improvement in the quality of life.
Antecedentes: Recientemente el síndrome de alergia oral (SAO) ha sido clasificado de acuerdo con los alimentos que lo inducen; fenotipo I, cuando está relacionado únicamente con alimentos derivados ...de plantas; fenotipo II, cuando además, está provocado por alimentos de origen animal.Objetivo: Determinar la prevalencia del SAO en adolescentes tardíos, según una nueva clasificación.Métodos: A través de un estudio transversal se analizaron los datos de 1,992 adolescentes, con edades de 15 a 18 años; la información se obtuvo a través de un cuestionario estructurado, donde se interrogó por la presencia de síntomas orales según el tipo de alimento ofensor. Se estimaron intervalos de confianza (IC) a 95% para proporciones.Resultados: La prevalencia global de SAO fue 1.7% (IC 95%: 1.2% a 2.4%); de SAO fenotipo I fue 0.85% y de fenotipo II fue 0.85%. Según el fenotipo, no hubo diferencia por sexo e historia personal de enfermedad atópica; en cambio, el tiempo de inicio de los síntomas mostró asociación con el fenotipo (p = 0.048). La frecuencia de los síntomas en piel y mucosas y las molestias respiratorias, no difirieron entre los grupos; pero en el caso de los síntomas gastrointestinales, la diarrea fue notoriamente más frecuente en el fenotipo II (p = 0.044).Conclusiones: Este estudio permitió identificar claramente dos grupos de pacientes con SAO, uno asociado exclusivamente a alimentos de origen vegetal y otro relacionado tanto con alimentos de origen vegetal, así como de origen animal.
Objective: To determine and interpret the range of normal deviation of the bucket test in healthy subjects
Subjects and methods: Study design: Cross-sectional study in a secondary care center. ...Inclusion criteria: subjects ≥18 years old with no otologic or neurologic symptoms and normal complete neuro-otological examination. The subjective visual vertical was evaluated binocularly using the bucket test. Five measurements were made on the clockwise direction and five on the counterclockwise direction. The examiner selected the starting point, the patient then manipulated the bucket and it stopped when the volunteer considered the line reached the vertical position.
Results: Fifty healthy volunteers were included, 16 (32%) were men, and 34 (68%) women with a mean age of 34 years. The mean value found clockwise was 1.93° ± 2.26° and counterclockwise sense was of 0.86° ± 2.44°. Mean normal values ranged from 1.4° ± 1.9°.
Conclusions: The bucket test is easy and quick to perform; we recommend to use a range of −1.0° to +3.0° as normal values in the healthy population.
Factors like ethnic origin and geographical area affect the frequency of cow's milk protein allergy (CMPA) and lactose intolerance (LI). Epidemiological information about the non-pediatric population ...is still missing.
To determine the prevalence of CMPA and LI in university students.
A cross-sectional study of 1200 students of 18 to 25-year-old. A structured questionnaire was applied in order to identify the clinical manifestations triggered by the intake of cow's milk (CM), and these were categorized as linked to CMPA or linked to LI.
Thirty students met the criteria for CMPA (prevalence of 2.5 %; CI 95 % = 1.7-3.6 %) and 128 for LI (prevalence of 10.7 %, CI 95 % = : 9.0 % - 12.5 %). The frequency of personal history of food allergy and dust mite allergy was higher in students with CMPA than in students with LI. Oral pruritus, skin and respiratory discomforts were predominant in CMPA. Abdominal cramps and flatulence were predominant in LI.
IL is more frequent than CMPA; which frequency was one in every 10 students; and the frequency of CMPA was one in 400.
Food allergy is considered a typical problem in the pediatric population, however, cases occur in adults more frequently.
To determine the prevalence of food allergy in patients with allergic ...rhinitis and asthma; as well as the foods and symptoms most related to said problem.
Through a cross-sectional study, the information of 257 adults with asthma or allergic rhinitis was analyzed. The information related to food allergy was obtained through a standardized interview; the confidence intervals (CI) were calculated for 95% proportions.
The prevalence of food allergy was 17.5% (95% CI = 13.3% to 22.6%). The main foods that caused symptoms were soy, shrimp, almonds, avocado and peanuts. The majority of patients who were allergic to a single food were 35.6%, two foods were 17.8% and three foods were 17.8%. The most frequent affections of food allergy were oral (62.2%): itching of the pharynx, tongue and palate; respiratory (26.7%), dyspnea and sneezing; and skin (26.7%), itching and hives.
Food allergy in adults with asthma or allergic rhinitis is a common problem. Oral symptoms are the main ailments in this type of patients and are mainly caused by soy.
Background: Recently, inflammatory cell ratios have gained importance as useful indicators in the categorization of asthma.
Objective: We compared the concentration of white blood cells in peripheral ...blood, as well as their respective inflammatory cell ratios, between patients with asthma and a healthy control group.
Methods: We performed cross-sectional analyses of the data obtained from 53 adult patients with asthma and 109 adult controls. In our study, we estimated and compared the following inflammatory cell ratios: Neutrophil-Lymphocyte Ratio (NLR), Eosinophil-Lymphocyte Ratio (ELR), Eosinophil-Neutrophil Ratio (ENR), Eosinophil-Monocyte Ratio (EMR), and Platelet-Lymphocyte Ratio (PLR). The magnitude of association was quantified with the odds ratio.
Results: In both groups, the average age was 33 years. In asthmatic patients, we obtained the following results: eosinophils ≥ 400 cells/µl, accounted for 37.7%; basophils ≥ 110 cells/µl, comprised 37.7%; and monocytes < 320 cells/µl, reached 11.3%. In the control group, the results were as follows: 4.6%, 9.2% and 0.9%, respectively. When compared to the control group, asthmatic patients had higher odds of eosinophils ≥ 400 cells/µl (OR = 12.61, p < 0.0001); higher odds of basophils ≥ 110 cells/µl (OR = 6.00, p < 0.0001); and increased odds of monocytes < 320 cells/µl (OR = 13.79, p = 0.017). NLR did not differ between our two groups; however, ELR, ENR, EMR and PLR were significantly higher in the asthma group.
Conclusions: Overall, patients with asthma have a higher concentration of eosinophils and basophils, fewer monocytes in their blood, and higher ratios of increased chronic inflammation.
Oral Allergy Syndrome Associated with Jicama Bedolla-Barajas, Martin; Ramses Bedolla-Pulido, Tonatiuh; Morales-Romero, Jaime ...
Medical journal of the Islamic Republic of Iran,
2022, Letnik:
36
Journal Article
Recenzirano
Odprti dostop
Background:
The occurrence of oral symptoms after food consumption defines oral allergy syndrome (OAS). Thus, our objective was to report the association of oral allergy syndrome triggered by jicama.
...Methods:
In this study, we report 10 cases of OAS associated with jicama eating.
Results:
Of the total cases, 6 were women; the mean age of the group was 28.3 ± 11.4 years. All patients suffered from allergic rhinitis and 3 of them also had asthma. On average, patients experienced the onset of symptoms 5 minutes after eating jicama. As expected, the patients had oral ailments, mainly itching in the pharynx, palate, and lips; furthermore, 4 out of 10 also had skin symptoms. The skin test by the prick-prick technique with fresh jicama had a mean diameter of 8.1 ± 5.4 mm.
Conclusion:
In closing, jicama should be considered as a cause of OAS, especially in regions where it is cultivated and eaten in large quantities.
Agroforestry is a promising method for enhancing land-use sustainability in the Bolivian Andes. However, its benefits in terms of rural development are under-recognized due to gaps in understanding ...users’ perceptions while taking into consideration both local and global environmental goals. Our study aimed to narrow these gaps by developing an analytical framework for analyzing the site-specific socio-ecological factors and interactions related to local woody species and assessing their ecological, economic, and socio-cultural plant values in order to identify the most promising agroforestry species. The framework was then tested in an indigenous community at 2,760–3,830 m a.s.l., incorporating vegetation surveys, environmental studies, and interviews on plant functions. Ecological, economic, and socio-cultural values and the ecological apparency of plants were calculated, and detrended correspondence and principal component analyses helped to reveal the socio-ecological context of significant factors for plant distribution and uses. Results showed dominating seral woody species along an altitudinal gradient. Although shrubs were more ecologically apparent than trees, trees were perceived to be more valuable as the usefulness and cultural importance of species increased with plant height and timber availability. Phytosociological factors played a minor but still significant role in perceived usefulness.
Schinus molle
and
Prosopis laevigata
(<3,200 m a.s.l.),
Polylepis subtusalbida
(>3,200 m a.s.l.), and
Baccharis dracunculifolia
(both zones) were evaluated as most promising for agroforestry use. In conclusion, our analytical framework proved to be a valuable tool for context-specific agroforestry plant selection. Nonetheless, economic, technical, and socio-cultural limitations of cultivating native agroforestry species were revealed as well. Agroforestry science and practice should, therefore, focus on enhancing reproductive potentials of existing woody vegetation, as well as problem-oriented horizontal dialogues between indigenous, expert, and scientific actors.
Antecedentes: La alergia a alimentos se considera un problema típico de la población pediátrica, sin embargo, los adultos se ven afectados cada vez con mayor frecuencia.Objetivo: Determinar la ...prevalencia de alergia a los alimentos en pacientes con rinitis alérgica y asma, así como los alimentos y los síntomas más relacionados con este problema.Métodos: Mediante un estudio transversal se analizaron los datos de 257 adultos con asma o rinitis alérgica. La información relacionada con la alergia a los alimentos se obtuvo por entrevista estandarizada. Se calcularon intervalos de confianza (IC) a 95 % para proporciones.Resultados: La prevalencia de alergia a alimentos fue de 17.5 % (IC 95 % = 13.3-22.6). Soya, camarón, almendra, aguacate y cacahuate fueron los alimentos que principalmente provocaron molestias; 35.6 % de los pacientes fue alérgico a un alimento, 17.8 % a dos y 17.8 % a tres. Las manifestaciones más frecuentes fueron las orales (62.2 %), prurito en faringe, lengua y paladar; las respiratorias (26.7 %), disnea y estornudos; y las cutáneas (26.7 %), comezón y ronchas.Conclusiones: La alergia a alimentos en adultos con asma o rinitis alérgica es un problema frecuente. Los síntomas orales son la principal molestia en este tipo de pacientes y principalmente son provocados por la soya.
Antecedentes: El origen étnico y la zona geográfica influyen en la frecuencia de la alergia a la proteína de leche de vaca (APLV) y de intolerancia a la lactosa. Faltan datos epidemiológicos en ...población no pediátrica.Objetivo: Determinar la prevalencia de APLV e intolerancia a la lactosa en estudiantes universitarios.Métodos: Estudio transversal de 1200 estudiantes de 18 a 25 años. Se aplicó cuestionario estructurado para identificar manifestaciones clínicas desencadenadas por la ingesta de leche de vaca y fueron categorizadas como relacionadas con APLV o intolerancia a la lactosa.Resultados: 30 estudiantes cubrieron criterios para APLV (prevalencia de 2.5 %; IC 95 % = 1.7-3.6) y 128 para intolerancia a la lactosa (prevalencia de 10.7 %, IC 95 % = 9.0-12.5). Los estudiantes con APLV tuvieron mayor frecuencia de historia personal de alergia a alimentos y alergia a ácaros del polvo casero, comparados con los estudiantes con intolerancia a la lactosa. El prurito oral y las molestias cutáneas y respiratorias predominaron en la APLV. El cólico abdominal y las flatulencias predominaron en la intolerancia a la lactosa.Conclusiones: La intolerancia a la lactosa fue más frecuente que la APLV; se observó en uno de cada 10 estudiantes y la APLV en uno de cada 400.
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