Fire is a fundamental, transformative, yet poorly understood process in the Earth system; it can radically reorganize ecosystems, alter regional carbon and energy balances, and change global climate. ...Short-term fire histories can be reconstructed from satellite (seasonal- to interannual-scales), historical (decadal scales), or dendrochronological records (for recent centuries), but only sedimentary charcoal records enable an analysis of the complex interactions between climate, vegetation and people that drive fire activity over longer temporal scales. This dissertation describes the compilation, synthesis and analysis of a global paleofire dataset and its application to understanding past, current, and future changes in fire activity. Specifically, I co-led efforts to compile charcoal records around the world into a single database, and to conduct three meta-analyses to understand the controls on fire at multiple spatial and temporal scales. The first meta-analysis reconstructed global biomass burning since the Last Glacial Maximum (LGM) 21,000 years ago. Results from this study demonstrated that global fire activity is low when conditions are cool and high when conditions are warm. This fundamental relationship between climate and fire is due in large part to associated changes in vegetation productivity. The second meta-analysis examined fire activity in North America during past abrupt climate changes and looked for evidence of continental-scale wildfires associated with a hypothesized comet impact ∼13,000 years ago. This analysis found a correlation between increased fire activity and abrupt climate change, but provided no evidence for continental-scale wildfires. A final meta-analysis disentangled the climate and human influences on global biomass burning during the past 2000 years; it found a close relationship between climate change and biomass burning until ∼1750 A.D., when human activities became a primary driver of global fire activity. Together, these three meta-analyses demonstrate that climate change is the primary control of global fire activity over long time scales. In general, global fire activity increases when the Earth's climate warms and decreases when climate cools. The paleofire data and analyses suggest that the rapid climate changes projected for coming decades will lead to widespread increases in fire frequency and biomass burning. This dissertation includes previously published and unpublished co-authored material.
Depression and suicide are of increasing concern on college campuses. This article presents data from the College Health Intervention Projects on the frequency of depression and suicide ideation ...among 1,622 college students who accessed primary care services in 4 university clinics in the Midwest, Northwest, and Canada. Students completed the Beck Depression Inventory and other measures related to exercise patterns, alcohol use, sensation seeking, and violence. The frequency of depression was similar for men (25%) and women (26%). Thought of suicide was higher for men (13%) than women (10%). Tobacco use, emotional abuse, and unwanted sexual encounters were all associated with screening positive for depression. “Days of exercise per week” was inversely associated with screening positive for depression. Because the majority of students access campus-based student health centers, medical providers can serve a key role in early identification and intervention. With every 4th student reporting symptoms of depression and every 10th student having suicidal thoughts, such interventions are needed.
Services Integration and Cost-Effectiveness Hilton, Michael E.; Fleming, Michael; Glick, Henry ...
Alcoholism, clinical and experimental research,
February 2003, Letnik:
27, Številka:
2
Journal Article, Conference Proceeding
Recenzirano
Alcohol treatment services are increasingly combined with other health and social services to address the needs of multiple‐problem clients. Hence, it has been of growing policy interest to find the ...most effective and the most cost‐effective ways of linking these services. This symposium presents some recent studies in this area. The small but growing body of studies in this area has great potential to inform public policy debates.
A hypothesized extraterrestrial impact in North America at 12,900 calendar years BP (12.9 ka) has been proposed as the cause of Younger Dryas climate changes, terminal Pleistocene mammalian ...extinctions, and a supposed "termination" of the Clovis archaeological culture. In regard to the latter, however, an examination of archaeological, geochronological, and stratigraphic evidence fails to provide evidence of a demographic collapse of post-Clovis human populations, especially where the Clovis and post-Clovis site records are reasonably well constrained chronologically. Although few Clovis sites contain evidence of an immediate post-Clovis occupation, interpreting that absence as population collapse is problematic because the great majority of Paleoindian sites also lack immediately succeeding occupations. Where multiple occupations do occur, stratigraphic hiatuses between them are readily explained by geomorphic processes. Furthermore, calibrated radiocarbon ages demonstrate continuous occupation across the time of the purported "Younger Dryas event." And, finally, the relatively few sites purported to provide direct evidence of the l2.9-ka impact are not well constrained to that time. Whether or not the proposed extraterrestrial impact occurred is matter for empirical testing in the geological record. Insofar as concerns the archaeological record, an extra-terrestrial impact is an unnecessary solution for an archaeological problem that does not exist. PUBLICATION ABSTRACT
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
The epidermal growth factor receptor (EGFR) and associated receptors ERBB2 and ERBB3 are important for skin development and homeostasis. To date, ERBB4 could not be unambiguously identified in the ...epidermis. The aim of this study was to analyze the ERBB-receptor family with a special focus on ERBB4 in vitro in human keratinocytes and in vivo in human and murine epidermis.
We compared the transcript levels of all ERBB-receptors and the seven EGFR-ligands in HaCaT and A431 cells. ERBB-receptor activity was analyzed after epidermal growth factor (EGF) stimulation by Western blot analysis. The location of the receptors was investigated by immunofluorescence in human keratinocytes and skin. Finally, we investigated the function of ERBB4 in the epidermis of skin-specific ERBB4-knockout mice.
After EGF stimulation, all ligands were upregulated except for epigen. Expression levels of EGFR were unchanged, but all other ERBB-receptors were down-regulated after EGF stimulation, although all ERBB-receptors were phosphorylated. We detected ERBB4 at mRNA and protein levels in both human epidermal cell lines and in the basal layer of human and murine epidermis. Skin-specific ERBB4-knockout mice revealed a significantly reduced epidermal thickness with a decreased proliferation rate.
ERBB4 is expressed in the basal layer of human epidermis and cultured keratinocytes as well as in murine epidermis. Moreover, ERBB4 is phosphorylated in HaCaT cells due to EGF stimulation, and its deletion in murine epidermis affects skin thickness by decreasing proliferation.
ERBB4 is expressed in human keratinocytes and plays a role in murine skin homeostasis.
•EGF-stimulation in human keratinocytes not only affects EGFR but also ERBB2-4.•First characterization of the ERBB4-receptor in murine skin•ERBB4 plays a role in cell proliferation and skin homeostasis in murine epidermis.
Clinical Spectrum of Pheochromocytoma Guerrero, Marlon A., MD; Schreinemakers, Jennifer M.J., MD; Vriens, Menno R., MD, PhD ...
Journal of the American College of Surgeons,
12/2009, Letnik:
209, Številka:
6
Journal Article
Recenzirano
Background Pheochromocytomas vary in presentation, tumor size, and in catecholamine production. Whether pheochromocytoma size correlates with hormone levels, clinical presentation, and perioperative ...complications is not known. The goal of this study was to determine if tumor size and hormone level correlate according to the clinical presentation at diagnosis. Study Design We retrospectively analyzed all patients who underwent an adrenalectomy with a diagnosis of a pheochromocytoma from February 1996 to October 2008. We grouped patients according to their clinical presentation at diagnosis (routine biochemical screening, incidentaloma, classic symptoms, pheochromocytoma crisis) and obtained preoperative radiographic tumor size and catecholamine hormone levels. ANOVA was used for the group effects and the Kruskal–Wallis rank test was used for pairwise comparison between groups with the Sidak/Bonferroni method for multiplicity adjustment according to age, tumor size, and hormone level. The Pearson correlation coefficient was then calculated to determine if hormone level correlated with tumor size. Results Eighty-one of 107 patients had data available for complete analysis. The average age at diagnosis for all patients was 47.1 years, and the average tumor size was 4.9 cm. The average highest hormone ratio among all patients was 27.4. Tumor size and hormone ratio levels differed among all groups (p ≤ 0.03). A direct correlation (p = 0.014) was apparent between tumor size and hormone level. Complication rates also differed among the four groups of patients (p ≤ 0.02). Conclusions Our study showed that tumor size directly correlates with hormone level. Smaller tumors tend to secrete lower levels of catecholamines, but larger tumors have a wider variation in secretory potential. Larger tumors, however, produced the highest hormone ratios.
xvii, 205 p. : ill. (some col.) A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number.
Fire is a fundamental, transformative, ...yet poorly understood process in the Earth system; it can radically reorganize ecosystems, alter regional carbon and energy balances, and change global climate. Short-term fire histories can be reconstructed from satellite (seasonal- to interannual-scales), historical (decadal scales), or dendrochronological records (for recent centuries), but only sedimentary charcoal records enable an analysis of the complex interactions between climate, vegetation and people that drive fire activity over longer temporal scales. This dissertation describes the compilation, synthesis and analysis of a global paleofire dataset and its application to understanding past, current, and future changes in fire activity.;
;
Specifically, I co-led efforts to compile charcoal records around the world into a single database, and to conduct three meta-analyses to understand the controls on fire at multiple spatial and temporal scales. The first meta-analysis reconstructed global biomass burning since the Last Glacial Maximum (LGM) 21,000 years ago. Results from this study demonstrated that global fire activity is low when conditions are cool and high when conditions are warm. This fundamental relationship between climate and fire is due in large part to associated changes in vegetation productivity. The second meta-analysis examined fire activity in North America during past abrupt climate changes and looked for evidence of continental-scale wildfires associated with a hypothesized comet impact ∼13,000 years ago. This analysis found a correlation between increased fire activity and abrupt climate change, but provided no evidence for continental-scale wildfires. A final meta-analysis disentangled the climate and human influences on global biomass burning during the past 2000 years; it found a close relationship between climate change and biomass burning until ∼1750 A.D., when human activities became a primary driver of global fire activity. Together, these three meta-analyses demonstrate that climate change is the primary control of global fire activity over long time scales. In general, global fire activity increases when the Earth's climate warms and decreases when climate cools. The paleofire data and analyses suggest that the rapid climate changes projected for coming decades will lead to widespread increases in fire frequency and biomass burning.;
;
This dissertation includes previously published and unpublished co-authored material.
Committee in charge: Patrick Bartlein, Chairperson, Geography;;
Daniel Gavin, Member, Geography;;
W. Andrew Marcus, Member, Geography;;
Cathy Whitlock, Member, Geography;;
Ronald Mitchell, Outside Member, Political Science
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