In this work we report the experimental results obtained in an isothermal fixed-bed hydrotreating reactor using an industrial feedstock consisting of a blend of 85
vol% of straight-run gas oil and 15
...vol% of light cycle oil. All tests were carried out with a commercial Co–Mo/Al
2O
3 catalyst at a total pressure of 54
kg/cm
2, LHSV of 1–2
h
−1, temperature of 350–370°C and constant hydrogen-to-oil ratio of 2000 ft
3/bbl. The effect of hydrogen sulfide concentration in gas on sulfur, nitrogen and aromatics in product was studied in the range 0–10
mol%. The experimental results show that the inhibiting effect of hydrogen sulfide on sulfur, nitrogen and aromatics contents is lower at high temperature. Other product properties, such as cetane index and API gravity, showed relatively little changes when the hydrogen sulfide concentration in gas was increased.
It has been suggested that type of chimeric mRNA is associated with differences in the clinical and hematologic characteristics of chronic myeloid leukemia (CML). However, prognostic value of type of ...chimeric mRNA bcr-xabl (b3a2 or b2a2) is still controversial.
We analyzed 97 cases of Philadelphia-positive CML to determine mRNA type by reverse-polymerase chain reaction (RT-PCR) and its relationship with clinical features.
We detected b3a2 bcr-abl transcripts in 27 (28%) cases, b2a2 in 57 (59%) cases, and 13 (13%) with both mRNA transcripts b3a2/b2a2. These frequencies were the total reverse of other reports. Age, sex, hemoglobin, and white-cell counts showed no significant difference for those with either b3a2 or b2a2 bcr-abl transcripts. However, platelet counts of b3a2 patients were significantly higher than those of b2a2 patients (743.3 vs 477.3 x 109/L; p = 0.01). In addition, in the subgroup of patients whose white-cell count at diagnosis was < 100 x 10(9)/L, those with b3a2 transcript had a significantly higher platelet count (679.1 vs. 352.2 x 10(9)/L; p = 0.001).
We observed reversed frequency of bcr-abl transcripts in this population, but agreement with other Latin-American reports. In addition, our data suggested that there is different CML biological behavior in our population and that there is a subpopulation of CML patients in whom b3a2 is associated witH higher thrombopoietic activity.
