The mode of action of antioestrogens is in blocking oestrogen receptors in the target cell cytoplasm. For this reason they can be used only in cases where basal oestrogen activity is present. We ...treated two groups of patients with antioestrogens. In the first group (30 patients) with oligomenarrhoe and an ovulatory sterility we had 15 pregnancies. In the second group of 26 patients with amenorrhoe and sterility we had 4 of pregnancies and 12 menstruations. In this very small group a child with enterocoele was born to a 38-years old patient. All other patients' children were normal. Out of 19 pregnancies 4 were completed by early abortion.
Two cases with expanding pituitary tumours following treatment with 2-bromo-alpha-ergocryptine are presented. The lack of normal response to the usual therapeutic dose of the drug suggests the ...presence of an organic hypothalamo-pituitary disorder that might favour the expansion of a pituitary tumour.
Three cases of carcinoma in situ were found by testicular biopsy among a group of 85 infertile men, most with diagnosed azoospermia. It remains difficult and unclear how to manage such patients to ...achieve offspring and to assure the adequate oncological therapy.
Abstract The purpose of this prospective randomized study was to evaluate use of a hyaluronan-rich transfer medium in fresh and frozen–thawed single blastocyst transfer. The study included 279 single ...blastocyst transfers in women aged <37 years in their first, second or third treatment cycle. According to the type of single blastocyst transfer (fresh elective or frozen–thawed) the women were divided into two study and two control groups. In both study groups ( n = 130) transfers were performed using hyaluronan and in the control groups ( n = 149) a conventional transfer medium was used. The results indicate that fresh elective single blastocyst transfer with hyaluronan results in significantly higher pregnancy rates in a selected subgroup of women; those with ≥2 blastocysts developed to day 5 and a previous implantation failure (55% versus 10%; P = 0.012). Overall pregnancy rates after fresh elective and frozen–thawed single blastocyst transfer were similar in both study and control groups.
Within the in vitro fertilization and embryo transfer procedure, 127 laparoscopies were performed in 89 women. The only indication was tubal infertility. There were 116 gonadotropin stimulated cycles ...and 11 clomiphene citrate stimulated cycles. Because of a limited ovarian access laparoscopic adhesiolysis was necessary in 30%. Egg recovery amounted to 440 oocytes in 92% successful laparoscopies, which represents 4.1 oocytes per laparoscopy. This resulted in 15 pregnancies of which 3 ended with spontaneous abortion, 6 biochemical and 6 ongoing pregnancies. Two pregnancies resulted in the live birth of normal twins, and one in the birth of a healthy girl.
The authors studied the response of the luteinizing hormone (LH), follicle-stimulating hormone (FSH), proclatin (PRL) and testosterone (T) to the intravenous injection of 100 microgram of synthetic ...gonadotropin-releasing hormone (GnRH) in hirsute women in the follicular phase, prior to and after the administration of cyproterone acetate (CPA). The GnRH stimulation before and after the CPA therapy induced a significant increase in plasma LH and FSH levels (P less than 0.01) and a significant drop in the plasma PRL concentration (p less than 0.05). Unchanged plasma T levels were observed during the test, prior to the CPA administration. Following the CPA application there was a significant increment of basal plasma PRL levels (p less than 0.05) and a significant drop of plasma FSH levels (p less than 0.01). No significant changes were observed, however, in LH and T levels. During the GnRH stimulation, after the administration of CPA, a significant decrease in T levels was noted (p less than 0.01). Considering basal concentrations of the hormones studied and the response to the LHR stimulation test, CPA was found to have no beneficial effect on the hypothalamic-pituitary dysfunction typical of androgenization in females.
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