Compact tokamak fusion reactors using advanced high-temperature superconducting magnets for the toroidal field coils have received considerable recent attention due to the promise of more compact ...devices and more economical fusion energy development. Facilities with combined fusion nuclear science and Pilot Plant missions to provide both the nuclear environment needed to develop fusion materials and components while also potentially achieving sufficient fusion performance to generate modest net electrical power are considered. The performance of the tokamak fusion system is assessed using a range of core physics and toroidal field magnet performance constraints to better understand which parameters most strongly influence the achievable fusion performance. This article is part of a discussion meeting issue 'Fusion energy using tokamaks: can development be accelerated?'.
High-performance and long-pulse operation is a crucial goal of current magnetic fusion research. Here, we demonstrate a high-connement plasma regime known as an H-mode with a record pulse length of ...over 30 s in the Experimental Advanced Superconducting Tokamak sustained by lower hybrid wave current drive (LHCD) with advanced lithium wall conditioning. We nd that LHCD provides a exible boundary control for a ubiquitous edge instability in H-mode plasmas known as an edge-localized mode, which leads to a marked reduction in the heat load on the vessel wall compared with standard edge-localized modes. LHCD also induces edge plasma ergodization that broadens the heat deposition footprint. The heat transport caused by this ergodization can be actively controlled by regulating the edge plasma conditions. This potentially offers a new means for heat-ux control, which is a key issue for next-step fusion development. PUBLICATION ABSTRACT
Summary
VRC‐HIVMAB060‐00‐AB (VRC01) is a broadly neutralizing HIV‐1 monoclonal antibody (mAb) isolated from the B cells of an HIV‐infected patient. It is directed against the HIV‐1 CD4 binding site ...and is capable of potently neutralizing the majority of diverse HIV‐1 strains. This Phase I dose‐escalation study in healthy adults was conducted at the National Institutes of Health (NIH) Clinical Center (Bethesda, MD, USA). Primary objectives were the safety, tolerability and pharmacokinetics (PK) of VRC01 intravenous (i.v.) infusion at 5, 20 or 40 mg/kg, given either once (20 mg/kg) or twice 28 days apart (all doses), and of subcutaneous (s.c.) delivery at 5 mg/kg compared to s.c. placebo given twice, 28 days apart. Cumulatively, 28 subjects received 43 VRC01 and nine received placebo administrations. There were no serious adverse events or dose‐limiting toxicities. Mean 28‐day serum trough concentrations after the first infusion were 35 and 57 μg/ml for groups infused with 20 mg/kg (n = 8) and 40 mg/kg (n = 5) doses, respectively. Mean 28‐day trough concentrations after the second infusion were 56 and 89 μg/ml for the same two doses. Over the 5–40 mg/kg i.v. dose range (n = 18), the clearance was 0·016 l/h and terminal half‐life was 15 days. After infusion VRC01 retained expected neutralizing activity in serum, and anti‐VRC01 antibody responses were not detected. The human monoclonal antibody (mAb) VRC01 was well tolerated when delivered i.v. or s.c. The mAb demonstrated expected half‐life and pharmacokinetics for a human immunoglobulin G. The safety and PK results support and inform VRC01 dosing schedules for planning HIV‐1 prevention efficacy studies.
ABSTRACT
GRANDMA (Global Rapid Advanced Network Devoted to the Multi-messenger Addicts) is a network of 25 telescopes of different sizes, including both photometric and spectroscopic facilities. The ...network aims to coordinate follow-up observations of gravitational-wave (GW) candidate alerts, especially those with large localization uncertainties, to reduce the delay between the initial detection and the optical confirmation. In this paper, we detail GRANDMA’s observational performance during Advanced LIGO/Advanced Virgo Observing Run 3 (O3), focusing on the second part of O3; this includes summary statistics pertaining to coverage and possible astrophysical origin of the candidates. To do so, we quantify our observation efficiency in terms of delay between GW candidate trigger time, observations, and the total coverage. Using an optimized and robust coordination system, GRANDMA followed-up about 90 per cent of the GW candidate alerts, that is 49 out of 56 candidates. This led to coverage of over 9000 deg2 during O3. The delay between the GW candidate trigger and the first observation was below 1.5 h for 50 per cent of the alerts. We did not detect any electromagnetic counterparts to the GW candidates during O3, likely due to the very large localization areas (on average thousands of degrees squares) and relatively large distance of the candidates (above 200 Mpc for 60 per cent of binary neutron star, BNS candidates). We derive constraints on potential kilonova properties for two potential BNS coalescences (GW190425 and S200213t), assuming that the events’ locations were imaged.
ABSTRACT Using spectroscopically selected galaxies from the Sloan Digital Sky Survey we present a detection of reddening effects from the circumgalactic medium of galaxies which we attribute to an ...extended distribution of dust. We detect the mean change in the colors of "standard crayons" correlated with the presence of foreground galaxies at as a function of angular separation. Following Peek & Graves, we create standard crayons using passively evolving galaxies corrected for Milky Way reddening and color-redshift trends, leading to a sample with as little as 2% scatter in color. We devise methods to ameliorate possible systematic effects related to the estimation of colors, and we find an excess reddening induced by foreground galaxies at a level ranging from 10 to 0.5 mmag on scales ranging from 30 kpc to 1 Mpc. We attribute this effect to a large-scale distribution of dust around galaxies similar to the findings of Ménard et al. We find that circumgalactic reddening is a weak function of stellar mass over the range - and note that this behavior appears to be consistent with recent results on the distribution of metals in the gas phase. We also find that circumgalactic reddening has no detectable dependence on the specific star formation rate of the host galaxy.
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