A granular cell tumor (GCT) in the central nervous system (CNS) of a ferret is a rare finding. In this case a cerebral GCT is described in a 5-year-old castrated female ferret. The animal developed ...lameness in right hind leg which progreseed to total ataxia. The animal died and a necropsy revealed the mass in the medial to caudal part of the left frontal lobe of the brain. Based on histological and imunohistochemical findings, tumor was diagnosed as granular cell tumor. Immunohistochemically, granular cells were diffusely positive for vimentin and neuron-specific enolase (NSE) and weakly focal reactivity for S-100 protein was seen. Neoplastic cells did not express cytokeratins and glial fibrillary acidic protein (GFAP). Although immunohistochemistry was performed, histogenesis of this tumor remains unsolved and controversial.
A histopathological analysis of 13 apocrine gland tumors and 22 sebaceous gland tumors in dogs was performed, which were submitted to the Department of Veterinary Pathology from 1 January 2010 to 31 ...December 2012. An association between the immunohistochemical expression of E-cadherin and Ki-67, the type, and the biological behavior of the tumors was investigated. The mean age of dogs with apocrine gland tumors was 10.15 years, and 10.91 years for sebaceous gland tumors. According to the histopathological analysis, 53.8% carcinomas and 46.2% adenomas of the apocrine glands were found. In the sebaceous gland tumors, epitheliomas were dominant (50.0%), followed by adenomas (36.4%) and carcinomas (13.6%). Survival time in dogs with sebaceous gland tumors was shortest in patients with diagnosed epitheliomas, intermediate in adenomas, and longest in carcinomas. The incidence of metastases was low in the groups with sebaceous adenomas and epitheliomas, and recurrence was most common in carcinomas. The average survival time was about the same for apocrine gland adenomas and carcinomas, with a higher incidence of metastases and recurrence for carcinomas. Immunohistochemical analysis of E-cadherin and Ki-67 expression confirmed the efficiency of this method for the accurate histological classification of apocrine and especially sebaceous gland tumors. The analyzes performed showed that the location and intensity of E-cadherin expression can be helpful in predicting the biological behavior of sebaceous gland tumors. In contrast to sebaceous gland tumors, the analysis of apocrine gland tumors showed that there was no correlation between E-cadherin expression and the biological behavior of apocrine gland tumors.
Visceral hemangiosarcoma were analyzed at the Department of Veterinary Pathology of the Faculty of Veterinary Medicine, University of Zagreb, over a 5-year period. From a total of 52 tumor masses in ...a total of 31 dogs, histological growth patterns (cavernous, capillary or solid) and the amount of tumor supporting stroma were evaluated. Additionally, sections were stained with toluidine blue for the purpose of mast cell detection and their number was determined in the tumor parenchyma, tumor stroma and edges. The average age of the affected animals was 10 years, males predominated, and the tumors occurred most frequently in cross breeds, German Shepherd dogs and Labrador Retrievers. The highest number of visceral hemangiosarcoma was found in the spleen (27/52). The most common growth pattern of visceral hemangiosarcoma was solely cavernous with a mixture of cavernous and solid patterns in different proportions. Mast cells were found in 44/52 (84.6%) of the visceral hemangiosarcomas. A smaller number of mast cells were found in the tumor parenchyma, and higher number were found in the stroma and tumor edges. The number of mast cells in tumors was not significantly associated with the tumor growth pattern, but there was a positive correlation between MCC - tumor parenchyma and stroma (rs = 0.28, P<0.05), MCC - tumor stroma + edges (rs = 0.74, P<0.05) and MCC - tumor parenchyma and MCC- tumor stroma+edges (rs = 0.30, P<0.05) in all the examined tumors. In splenic tumors, there was only a significant positive correlation between MCC - stroma+edges (rs P = 0.68 P<0.05). These results suggest a higher mast cell count in tumors with more developed stromal components in canine visceral hemangiosarcomas, and certainly indicate the need for further research on their role and the factors they release in the development and progression of hemangiosarcomas.
One of the current leading causes of death in pet cats is neoplasia. The scarcity of data on tumor prevalence in cats from south-eastern Europe led to this retrospective study which reports an ...abundant collection of tumors diagnosed in cats living in Croatia. Archived histopathology findings (diagnosis, cell origin, and biological behavior), and epidemiological data (breed, sex, age, and anatomical site of the tumor) of the cats diagnosed with at least one tumor were collected and statistically analyzed. For the research, 2338 archived feline samples, obtained from 2009-2019, have been reviewed. In 659 samples (28.1%) one or more tumors were diagnosed. Tumors have most often affected non-pedigree cats, cats between 7 and 15 years of age, and female cats. Most tumors showed malignant behavior (85.7%). The most frequent diagnoses were mammary adenocarcinoma, lymphoma, and squamous cell carcinoma. Regarding origin, most samples were epithelial (46.9%), but mesenchymal (28.7%) and lymphoid tumors (17.0%) were also frequently found. Tumors most often occurred in the skin and subcutis, mammary gland (in females), digestive system, and hemolymphatic system (in males). Statistical analysis did not reveal breed, sex, and age predisposition, but female animals and non-pedigree cats were significantly more likely to develop malignant tumors. This detailed study gives insight into the most frequent tumors that occur in cats from Croatia, and the data reported here is likely applicable to other countries. This data will contribute to clinical veterinary oncology, as it presents the most extensive tumor index of cats in south-eastern Europe.
•Staphylococcus pseudintermedius is a commensal bacterium residing on the mucosae and skin surfaces of dogs.•S pseudintermedius has emerged as a global concern in small animal practices.•This report ...describes pyometra associated with S pseudintermedius in two bitches.•In one bitch the infection was lethal due to septic shock.•In the other bitch the bacteria caused pyometra with suppurative peritonitis.
Staphylococcus pseudintermedius is a commensal bacterium residing on the mucosae and skin surfaces of dogs. Under favorable conditions, the organism may cause serious infections, primarily involving the skin, but it is also isolated in eye and ear infections. This report describes pathologic findings of pyometra associated with S pseudintermedius in two bitches.
One bitch was a 6-year-old Pomeranian bitch who died after three days of diarrhea, vomiting, and depression. During necropsy, the uterus of the bitch was diffusely enlarged and filled with 30 mL of thick, yellow, creamy pus. Histology revealed acute to subacute, diffuse, severe, purulent endometritis with intralesional Gram-positive round cocci revealed as S pseudintermedius. The cause of death was pyometra with subsequent septic shock.
The other bitch was a 2-year-old West Highland White Terrier who underwent diagnostic laparotomy due to suppurative peritonitis of unknown cause. During the procedure, about 100 mL of yellow, opaque exudate from the abdominal cavity was removed. The distended uterine horns noted during the procedure were removed and submitted for histopathology which revealed necrosis of endometrium with the accumulation of pus and numerous, intralesional S pseudintermedius in the uterine lumen. Focally, uterine wall necrosis was evident, with a spread of bacteria and purulent inflammation into the adjacent mesometrium causing purulent peritonitis.
Although S pseudintermedius presents a common cause of skin and mucosal infection, it should be considered a possible etiological agent of canine pyometra.
Dijafragmatska hernija u mačaka Mihoković Buhin, Ivana; Šoštarić-Zuckermann, Ivan-Conrado
Hrvatski veterinarski vjesnik,
09/2021, Letnik:
29, Številka:
3
Paper
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Dijafagmatska hernija jest svaka dislokacija organa trbušne šupljine kroz nastali defekt na ošitu. To može biti urođena, ali najčešće je stečena lezija, općenito govoreći zbog porasta tlaka unutar ...trbušne šupljine. Peritoneoperikardijalna dijafragmatska hernija (PPDH) jest kongenitalna anomalija koju obilježava nepotpun razvoj ošita i komunikacija između osrčja i trbušne šupljine. Gotovo svi organi trbušne šupljine mogu proći kroz oštećenje na ošitu, ali najčešće su to crijeva i jetra. U ovom je radu prikazana makroskopska slika dijafragmatske hernije u dvije mačke obducirane u Zavodu za veterinarsku patologiju Veterinarskog fakulteta Sveučilišta u Zagrebu.
Unilateralna agenezija bubrega pojavljuje se relativno rijetko u svih domaćih životinja, pa tako i u
pasa. Sama po sebi ova je promjena kompatibilna sa životom i životinja nema nikakve simptome
sve ...dok je drugi bubreg funkcionalan. U ovom je osvrtu s patološkog aspekta prikazan slučaj u
psa u kojega je unilateralna agenezija bubrega pridonijela zatajenju bubrega s obzirom na to da je
kontralateralni bubreg bio zahvaćen uznapredovalim stadijem fibroze, vjerojatno uzrokovanim primarnim glomerulonefritisom.
Panleukopenija mačaka Mihoković Buhin, Ivana; Medven Zagradišnik, Lidija; Huber, Doroteja ...
Hrvatski veterinarski vjesnik,
10/2019, Letnik:
27, Številka:
5/6
Paper
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Panleukopenija mačaka virusna je zarazna bolest, koja se naziva i parvovirusni enteritis mačaka. Obolijevaju pretežno životinje u dobi od trećega do petog mjeseca starosti. Uzročnik je bolesti virus ...mačje panleukopenije (FPV), DNA virus koji pripada porodici Parvoviridae, rodu Parvovirus, ubikvitaran je, iznimno stabilan u okolišu (preživljava godinu dana i više) i vrlo infektivan. Dominantan kliničkopatološki nalaz jest panleukopenija zbog djelovanja virusa na stanice koštane srži. Rana oštećenja uključuju depleciju limfnih stanica i involuciju timusa, dok je u kasnijoj fazi bolesti zahvaćeno pretežno tanko crijevo, primarno kriptalnih stanica. U ovom je radu prikazana makroskopska i histopatološka slika panleukopenije mačaka u mačke bengalske pasmine, čija je razudba obavljena u Zavodu za veterinarsku patologiju Veterinarskoga fakulteta Sveučilišta u Zagrebu.
Granularni stanični tumor u središnjem živčanom sustavu tvora (Mustela putorius furo) rijetka je pojava, a ovom radu opisan je kod pet godina stare ženke. Životinja je razvila šepavost stražnje desne ...noge koja je prerasla u potpunu ataksiju. Nakon uginuća napravljena je obdukcija kojom je otkrivena masa u medijalnom do kaudalnom dijelu lijevog frontalnog režnja mozga. Na temelju histološkog i imunohistokemijskog nalaza, tumor je dijagnosticiran kao granularni stanični tumor. Imunohistokemijski su u ovom slučaju tumorske stanice bile difuzno pozitivne na vimentin i neuron-specifičnu enolazu (NSE), a uočena je slaba fokalna reaktivnost na S-100 protein. Neoplastične stanice nisu eksprimirale citokeratine i glialni fibrilarni kiseli protein (GFAP). Iako je napravljena imunohistokemijska analiza, histogeneza ovog tumora ostaje neutvrđena i kontroverzna.
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