We report on the discovery of HAT-P-11b, the smallest radius transiting extrasolar planet (TEP) discovered from the ground, and the first hot Neptune discovered to date by transit searches. HAT-P-11b ...orbits the bright (V = 9.587) and metal rich (Fe/H = +0.31 +- 0.05) K4 dwarf star GSC 03561-02092 with P = 4.8878162 +- 0.0000071 days and produces a transit signal with depth of 4.2 mmag, the shallowest found by transit searches that is due to a confirmed planet. We present a global analysis of the available photometric and radial velocity (RV) data that result in stellar and planetary parameters, with simultaneous treatment of systematic variations. The planet, like its near-twin GJ 436b, is somewhat larger than Neptune (17 M{sub +}, 3.8 R{sub +}) both in mass M{sub p} = 0.081 +- 0.009 M{sub J}(25.8 +- 2.9 M{sub +}) and radius R{sub p} = 0.422 +- 0.014 R{sub J}(4.73 +- 0.16 R{sub +}). HAT-P-11b orbits in an eccentric orbit with e = 0.198 +- 0.046 and omega = 355.{sup 0}2 +- 17.{sup 0}3, causing a reflex motion of its parent star with amplitude 11.6 +- 1.2 m s{sup -1}, a challenging detection due to the high level of chromospheric activity of the parent star. Our ephemeris for the transit events is T{sub c} = 2454605.89132 +- 0.00032 (BJD), with duration 0.0957 +- 0.0012 days, and secondary eclipse epoch of 2454608.96 +- 0.15 days (BJD). The basic stellar parameters of the host star are M{sub *} = 0.809{sup +0.020}{sub -0.027} M{sub sun}, R{sub *} = 0.752 +- 0.021 R{sub sun}, and T{sub eff*} = 4780 +- 50 K. Importantly, HAT-P-11 will lie on one of the detectors of the forthcoming Kepler mission; this should make possible fruitful investigations of the detailed physical characteristic of both the planet and its parent star at unprecedented precision. We discuss an interesting constraint on the eccentricity of the system by the transit light curve and stellar parameters. This will be particularly useful for eccentric TEPs with low-amplitude RV variations in Kepler's field. We also present a blend analysis, that for the first time treats the case of a blended transiting hot Jupiter mimicking a transiting hot Neptune, and proves that HAT-P-11b is not such a blend.
Base Excision Repair (BER) efficiently corrects the most common types of DNA damage in mammalian cells. Step-by-step coordination of BER is facilitated by multiple interactions between enzymes and ...accessory proteins involved. Here we characterize quantitatively a number of complexes formed by DNA polymerase β (Polβ), apurinic/apyrimidinic endonuclease 1 (APE1), poly(ADP-ribose) polymerase 1 (PARP1), X-ray repair cross-complementing protein 1 (XRCC1) and tyrosyl-DNA phosphodiesterase 1 (TDP1), using fluorescence- and light scattering-based techniques. Direct physical interactions between the APE1-Polβ, APE1-TDP1, APE1-PARP1 and Polβ-TDP1 pairs have been detected and characterized for the first time. The combined results provide strong evidence that the most stable complex is formed between XRCC1 and Polβ. Model DNA intermediates of BER are shown to induce significant rearrangement of the Polβ complexes with XRCC1 and PARP1, while having no detectable influence on the protein-protein binding affinities. The strength of APE1 interaction with Polβ, XRCC1 and PARP1 is revealed to be modulated by BER intermediates to different extents, depending on the type of DNA damage. The affinity of APE1 for Polβ is higher in the complex with abasic site-containing DNA than after the APE1-catalyzed incision. Our findings advance understanding of the molecular mechanisms underlying coordination and regulation of the BER process.
Background Drug-induced aseptic meningitis is a rare, but challenging diagnosis, most commonly reported with nonsteoroidal anti-inflammatory drugs (NSAIDs) and antibiotics. ...Trimethoprim/sulfamethoxazole (TMP/SMX) is a sulfonamide that is widely used in clinical practice for the treatment and prophylaxis of various infections. The most common side effects associated with TMP/SMX are generally mild and self-limited, but serious side effects have been reported, including liver injury and aseptic meningitis. Case presentation We report a 2,5 year old Dutch girl with both drug-induced aseptic meningitis and drug-induced liver injury while using TMP/SMX prophylaxis. Ursodeoxycholic acid was started because of cholestatic injury. After cessation of TMP/SMX, full convalescence was reached within weeks. Conclusions This is the first report of a young patient with both aseptic meningitis and drug-induced liver injury caused by TMP/SMX. Drug-induced aseptic meningitis and cholestatic hepatitis constitute a considerable diagnostic challenge to clinicians. In addition to a thorough evaluation for infectious causes, clinicians should be aware of drug-induced aseptic meningitis and cholestatic hepatitis. Keywords: Case report, Aseptic meningitis, Hepatitis, Drug-induced, Trimethoprim-sulfamethoxazole
Background Alternative techniques have been developed to address pain after shoulder arthroplasty and are well documented. We evaluated the effect of adding intraoperative liposomal bupivacaine and ...intravenous dexamethasone during shoulder arthroplasty. Methods We retrospectively reviewed 2 consecutive cohorts undergoing elective shoulder arthroplasty. The 24 patients in cohort 1 and the 31 patients in cohort 2 received perioperative multimodal management with preoperative and postoperative intravenous and oral narcotics, gabapentin, nonsteroidal anti-inflammatory drugs, acetaminophen, and single-injection interscalene block. Cohort 2 also received 8 to 10 mg of intravenous dexamethasone intraoperatively after the skin incision and liposomal bupivacaine injected at surgery. Patients who did and did not use preoperative narcotics were analyzed together and separately. We evaluated hospitalization length of stay, narcotic use, and visual analog scale pain before and after the change in the perioperative protocol. Results Cohort 1 was hospitalized longer (2 vs. 1 day; P < .001), required more narcotics on postoperative day 1 (21.0 vs. 10.0 mg; P < .001) and days 0 and 1 cumulatively (30.5 vs. 17.5 mg; P = .001), and had more pain on postoperative days 0 (6.5 vs. 3.5; P < .001) and 1 (7.5 vs. 3.5; P < .001) than cohort 2. In patients using preoperative narcotics, cohort 2 had less pain on postoperative day 1 (3.5 vs. 7.0; P = .006), less cumulative narcotic use (20 vs. 58.5 mg; P = .03), and shorter hospitalization (1 vs. 2 days; P = .052) than cohort 1. Conclusion These changes to the perioperative shoulder arthroplasty protocol decreased hospitalization length of stay, narcotic requirement, and pain.
Context. Debris disks correspond to the final evolutionary stage of circumstellar disks around young stars. Gas-deprived structures seen in debris disks are normally, but not always, attributed to ...dynamical interactions in young planetary systems. Aims. The debris disk of HIP 73145 has been detected in scattered light in the near-IR, and at far-IR wavelengths before, but no substructure has been seen so far. Detection of such substructures in combination with detailed modeling can hint at the presence of perturbing planetary bodies, or reveal other mechanisms acting to replenish gas and dust reservoirs and forming structures such as spirals or rings. Methods. We obtained multiwavelength images with SPHERE in the near-IR in the H2 and H3 bands with the IRDIS camera and a 0.95−1.35 μm spectral cube with the IFS. Data were acquired in pupil-tracking mode, thus allowing for angular differential imaging. The SPHERE standard suite of angular differential imaging algorithms was applied. ALMA Band 6 observations complement the SPHERE data. Results. We detect a bright ring of scattered light plus some secondary structures inside, at least one of them forming a secondary, concentric ring with the first. This is the first detection of this disk in total-intensity scattered light. A second object is detected in the field at high contrast but concluded to be a background star. Forward modeling yields information on the primary parameters of the disk and confirms that the detected substructures are not due to the data analysis approach, which sometimes leads to spurious structures. Conclusions. We detect a series of concentric rings in the disk around HIP 73145. This is one of the rare cases where multiple components are necessary to fit the SED and are also detected in scattered light. The presence of such ring structures somewhat questions the nature of the object as a pure debris disk, but the gas and dust content would presumably offer sufficient explanations for such structures to form.
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