PurposeThe onset of a crisis demands that businesses respond quickly and effectively. So, it might be helpful to examine the effect of business model innovation and how to increase its impact on ...better crisis management. This study aims to discuss the aforementioned objectives.Design/methodology/approachThe present study is applied in terms of aim and a quantitative descriptive survey regarding the data collection method. The structural equation model with the partial least squares approach and Smart PLS 3 software was used for the structural analysis of the questionnaire.FindingsThe findings revealed that business model innovation could lead to better crisis management. In addition, the components of entrepreneurial capability, resilience and business performance played a mediating role.Research limitations/implicationsSome factors may mediate the effect of business model innovation on crisis management. Thus, future research can investigate them and identify their impact.Practical implicationsThe present study suggests that managers should re-examine business model processes and make them innovative to improve crisis management.Originality/valueThe present study examines the factors that affect crisis management with an emphasis on innovation, assesses the impact of mediating factors in this regard and attempts to provide a model to facilitate better crisis management.
Patients with post-acute or long COVID-19 syndrome (PA-COVID) develop persistent symptoms and complications that last beyond 4 weeks of the initial infection. There is limited information regarding ...the pulmonary pathology in PA-COVID patients that require bilateral orthotopic lung transplantation (BOLT). Our experience with 40 lung explants from 20 PA-COVID patients that underwent BOLT is described. Clinico-pathologic findings are correlated with best evidence from literature. The lung parenchyma showed bronchiectasis (n=20) and severe interstitial fibrosis with areas resembling the nonspecific interstitial pneumonia (NSIP) pattern of fibrosis (n=20), interstitial fibrosis NOS (n=20) and fibrotic cysts (n=9). None of the explants exhibited a usual interstitial pneumonia (UIP) pattern of fibrosis. Other parenchymal changes included multinucleated giant cells (n=17), hemosiderosis (n=16), peribronchiolar metaplasia (n=19), obliterative bronchiolitis (n=6) and microscopic honeycombing (n=5). Vascular abnormalities included thrombosis of a lobar artery (n=1) and microscopic thrombi in small vessels (n=7). Systematic literature review identified 7 articles reporting the presence in 12 patients of interstitial fibrosis showing NSIP pattern (n=3), organizing pneumonia/diffuse alveolar damage (DAD) (n=4) and NOS (n=3) patterns. All but one of these studies also reported the presence of multinucleated giant cells and none of the studies reported the presence of severe vascular abnormalities.
PA-COVID patients undergoing BOLT show a pattern of fibrosis that resembles mixed cellular-fibrotic NSIP pattern and generally lack severe vascular complications. As the NSIP pattern of fibrosis is often associated with autoimmune diseases, additional studies are needed to understand the mechanism of disease and learn whether this information can be used for therapeutic purposes.
International markets and digital technologies are considered among the factors affecting business innovation. The emergence and deployment of digital technologies in emerging markets increase the ...innovation potential in businesses. Companies with an entrepreneurial orientation also strengthen their innovation capabilities. The present study aimed to investigate the impact of international markets and new digital technologies on business innovation in emerging markets, and to estimate the mediating effect of entrepreneurial orientation on this relationship. The present research was applied research in terms of aim and descriptive survey in terms of data collection method and quantitative in terms of the type of collected data. A standard questionnaire was to collect data. The study’s statistical population consisted of all companies providing business services in Tehran, Iran. To analyse the data, the structural equation modelling method with partial least squares method and Smart PLS-3 Software was used. The results revealed that international markets and digital technologies are positively associated with innovation. They also revealed that when a company’s entrepreneurial orientation increases, the digital technologies and international markets will be more involved in mutual relationships.
Neuroblastoma-like schwannoma is known as a rare unusual variant of schwannoma with difficulties of differential diagnosis with neuroblastoma, Ewing sarcoma/peripheral neuroectodermal tumor and other ...cutaneous small round cell tumors. Herein, we describe a neuroblastoma-like schwannoma that was presented as a painless lesion on the dorsal side of the left hand in a 39-year-old woman. Composed collagen fibers in the central core of rosettes and diffuse expression of S100 protein in the tumor cells found in the biopsy specimens confirmed the Schwann cell origin of the tumor.
Digital transformation and its unpredictable nature make future studies to be of paramount importance for dealing with a crisis and identifying market trends and opportunities existing in new ...markets. Moreover, future studies guarantee enterprises to develop accurate models toward their perspective and distinguish enterprises from their competitors. This study presents a strategic future study in entrepreneurial resiliency considering digital development trends in emerging markets. To do so, the researchers used the Delphi technique. The findings reveal that fifteen driving forces which panel experts suggested are effective in this regard. Artificial intelligence, data mining, environmental scanning, business circumstances prediction, and property research were of paramount importance among these forces. The paper concludes with some directions for future research and suggestions for policymakers and practitioners.
La transformación digital y su naturaleza impredecible hacen que la investigación futura sea de suma importancia para identificar las tendencias y oportunidades en mercados existentes y emergentes. Además, los estudios futuros garantizan que las empresas desarrollen modelos precisos con respecto a su perspectiva y logren distinguirse de sus competidores. Este artículo presenta un estudio estratégico de cara al futuro en resiliencia empresarial considerando las tendencias de desarrollo digital en mercados emergentes. Para ello, se utiliza la técnica Delphi. Los hallazgos revelan quince fuerzas impulsoras sugeridas por el panel de expertos. La inteligencia artificial, la minería de datos, el escaneo ambiental, la predicción de circunstancias comerciales y la investigación de propiedades fueron de suma importancia entre estas fuerzas. El documento concluye con algunas recomendaciones para futuras investigaciones y sugerencias para legisladores y profesionales.
Entrepreneurial ventures face various problems contributing to the regional resilience of their districts. Among such firms are digital platform‐based businesses that could have exponential ...impacts—indeed, if they succeed in overcoming the barriers. Thus, this study aims to identify the major technological barriers to creating regional resilience in Iran's innovation districts. This study uses the analytical hierarchy process method and an unsupervised machine learning algorithm, as well as the Delphi technique. Online panel surveys are conducted to collect data from experts in the field of online social platforms. The findings show that digital literacy barriers and cultural barriers are the criteria with the uppermost and lowermost importance. Performance sensitivity analysis illustrates that considering the C1 and C4 criteria, the Digikala platform is more resistant to technological barriers compared to other platforms. Furthermore, based on C2 and C3 criteria, it can be stated that the Snapp platform reveals better resistance than the other platforms. The importance‐performance matrix also shows that all platforms need more attention in terms of performance. Besides, the results of the BIRCH analysis show that the present model's accuracy is 88%. Meanwhile, outputs show that experts are divided into four groups or four different thoughts.
Summary
Background
Distinction between alopecia areata (AA) and androgenic alopecia (AGA) can be made according to clinical presentation and biopsy findings. However, it is sometimes difficult to ...differentiate them, especially when the diffuse pattern of both AA and AGA is in the differential diagnosis of hair loss in androgen‐dependent areas.
Objectives
To evaluate the characteristics of inflammatory cell infiltration using CD3, CD4, CD8, and CD20 antigens, in AA and AGA to find some consistent histological clues for distinguishing these two entities.
Methods
A retrospective analysis of patients with diagnosed AA (30 cases) and AGA (30 cases) was performed based on the clinical and histopathological criteria. We studied immunohistochemical findings for CD3, CD4, CD8, and CD20 in all selected cases.
Results
Immunohistochemical stains for CD4 and CD20 were not helpful in differentiating AA from AGA, but the inflammation density for AA was significantly (P‐value = .025, .001) higher than AGA in CD3 (specificity= 86.7% and sensitivity= 96.7%) and CD8 (specificity= 50% and sensitivity=86.6%). Our findings revealed that intrafollicular CD3 (P‐value = .017) and CD8 (P‐value = ˂.001) infiltrations were significantly higher in AA samples in comparison with AGA.
Conclusion
Characterization of CD3 and CD8 in IHC samples is helpful, especially when the density of CD3 and CD8 T cells are significant in more than 50% of the infiltrated cells and are located intrafolliculary. Moreover, the most specific and sensitive test for differentiating of AA from AGA is CD3.
Abstract Background aims Stem cells are commonly enumerated with bead-based methods in blood and marrow progenitor cell transplantation centers. We compared the International Society of Hematotherapy ...and Graft Engineering (ISHAGE) bead-based method with a true volumetric one that obviates the use of fluorescent beads for enumeration. Methods From 31 samples, including 15 peripheral blood samples and 16 leukapheresis products, CD34+ cells were enumerated with the single-platform bead-based ISHAGE method and a true volumetric method. After exclusion of two outliers, one from the peripheral blood group and the other from the leukapheresis group, the results were compared. Results In the peripheral blood category, no significant difference was observed. However, a proportional systematic error was seen in the leukapheresis group. The systematic error was corrected in the leukapheresis group using a regression line equation. The 95% confidence interval of differences was –5.83, 2.18 for the peripheral blood and –38.40, 38.77 for the leukapheresis group after correction of the systematic error. Conclusions The true volumetric method is a simple and reliable approach that can be used instead of the more popular bead-based procedures.
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