In the search for new materials with applicable magnetic properties in spintronic devices, the aim of this work is to report the synthesis of the lanthanide ferrocobaltite La2CoFeO6 using the ...modified Pechini route; the experimental study of structural, morphological and magnetic properties, and the analysis of the electronic structure and bands are obtained in the framework of the Density Functional Theory. Rietveld refinement of experimental X-ray diffraction patterns revealed the crystallization of this oxide material in a perovskite-like monoclinic structure, space group
P
21/
n
(# 14). Scanning electron microscopy and atomic force microscopy images revealed that the surface morphology is essentially polycrystalline, with mean grain sizes between 177 and 188 nm. The dispersive X-ray spectroscopy suggests that the material obtained contains La, Fe, Co and O in the stoichiometric proportions expected by up to 98%. The magnetic susceptibility curves as a function of temperature indicated that the material is ordered ferromagnetically, showing strong irreversibility effects due to the disorder of the Fe and Co cations in the three crystallographic directions of the structure and to the strong distortions in the FeO6 and CoO6 octahedra. Magnetic hysteresis curves confirmed the ferromagnetic character of the material for all temperatures evaluated, up to room temperature. I–V response curves revealed a semiconductor-like behavior with a figure of merit exponent 1.53 of the varistor type. The ferromagnetic semiconductor behavior suggests the potential applicability of the material in spintronic technological devices.
To describe real-life experience with sensor-augmented pump therapy with predictive low-glucose management (SAPT-PLGM), in terms of hypoglycemia and glycemic control after one year of follow-up in ...T1D patients with hypoglycemia as the main indication of therapy.
Retrospective cohort study under real life conditions. Baseline and one-year follow-up variables of glycemic control, hypoglycemia and glycemic variability were compared.
Fifty patients were included, 31 on prior treatment with SAPT with low-glucose suspend (LGS) feature and 19 on multiple dose insulin injections (MDI). Mean HbA1c decreased in the MDI group (8.24%–7.08%; p = 0.0001). HbA1c change was not significant in the SAPT-LGS group. Area under the curve (AUC) below 70 mg/dl improved in both SAPT-LGS and MDI groups while AUC, %time and events below 54 mg/dl decreased in SAPT-LGS group. Glycemic variability improved in the MDI group. Less patients presented severe hypoglycemia with SAPT-PLGM in both groups, however the change was non-significant.
Under real life conditions, SAPT-PLGM reduced metrics of hypoglycemia in patients previously treaded with MDI and SAPT-LGS without deteriorating glycemic control in SAPT-LGS patients, while improving it in patients treated with MDI.
•Green synthesis and multicomponent reaction of non-toxic of boron Schiff bases.•High photostability and water stability by tert-butyl bulky groups in compound 1.•Non-invasive fluorescence emission ...wavelength (573 nm) in compound 1.•Theoretical calculations for the understanding of chemical stable molecules.
Boron Schiff bases (BOSCHIBAs) are emerging fluorescent dyes for biological and multi-stimuli applications because of the soft synthesis, low cytotoxicity, and their attractive photophysical properties. In the present work, three boron compounds (tBu2SB-BPh2 (1), MeOSB-BPh2 (2), HOSB-BPh2(3) have been synthesized by microwave-assisted synthesis and multicomponent reaction. Because of the importance of generating molecules with high chemical stability and to the interesting medical applications of fluorescent boron compounds, the photophysical properties, photostability studies, and stability in the aqueous media of all compounds were evaluated. The results show that compound 1 with tert-butyl groups is highly photostable and water-stable compared to the rest of the compounds. High-resolution mass spectrometry was also used to observe greater chemical stability of the molecular ion of 1. The high photostability and stability in aqueous media, together with the results of low toxicity, make compound 1 appropriate for biomedical application as a fluorescent biomarker. The cytotoxicity at different concentrations of some BOSCHIBAs was investigated in non-cancer (HEK-293) and cancer (B16F10) cells. The superior stability of compound 1 was confirmed by theoretical calculations, where no evidence was found to show that the chemical-structural stability is because of another characteristic, rather than protecting the fluorophore by the tert-butyl groups.
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•The diagnosis of DLB is a challenge and people with DLB have poor prognosis.•In Latin America, there are no precise reports of the prevalence of DLB.•COL-DLB aims to describe DLB in Colombia and to ...explore biomarkers usefulness.•COL-DLB will provide a first panorama of the DLB in Colombia.
To study the quality of life (QoL) and functional neurological status of patients three years after suffering their first ischaemic cerebrovascular accident (CVA).
For the study we chose patients who ...presented ischaemic CVA, classified in categories I 63 to I 69. QoL and functional neurological status were measured using the modified Rankin Scale (mRS) and the SF-36 health questionnaire, respectively.
Of a total of 59 patients who answered the surveys (mean age: 62 years; sex: 51% females), nearly half of them (29 patients; 49.1%) presented some kind of disability (mRS = 2). Thirty patients (50.9%) were independent or presented minimum sequelae (mRS = 1) at the end of the follow-up period. The mean QoL with the SF-36 questionnaire progressively diminished as the mRS score increased, especially in the group with mRS = 3. Although the youngest age group (range: 20-36 years) got the best average score (84 points) on the SF-36, no significant differences were found with the remaining age groups; the group made up of 75-year-olds and above was the one that obtained the lowest average score (63 points). Extensive strokes (total anterior circulation infarctions) of a cardioembolic origin (atrial fibrillation) had the lowest QoL indexes (p < 0.05).
In the population that was analysed, the QoL was inversely proportional to the age and the severity of the functional deficit of patients who survived a completed stroke, especially in the cardioembolic-origin subgroup, due to its being associated with more extensive cerebral infarcts.
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