We propose to use the High Momentum Spectrometer of Hall C combined with the Neutral Particle Spectrometer (NPS) to perform high precision measurements of the Deeply Virtual Compton Scattering (DVCS) ...cross section using a beam of positrons. The combination of measurements with oppositely charged incident beams is the only unambiguous way to disentangle the contribution of the DVCS
2
term in the photon electroproduction cross section from its interference with the Bethe-Heitler amplitude. This provides a stronger way to constrain the Generalized Parton Distributions of the nucleon. A wide range of kinematics accessible with an 11 GeV beam off an unpolarized proton target will be covered. The
Q
2
-
dependence of each contribution will be measured independently.
It is well known that protons and neutrons are made from constituents, called quarks and gluons, which give substructure to these particles. The goal of this project is to make measurements of the ...spatial distributions and the momenta of the quarks that provide a three-dimensional map of quarks in the nuclear medium. This knowledge provides the basis of our understanding of nuclear matter in terms of the dynamics of their internal constituents. This abstract focuses on the study of the contribution of the sea quarks and in particular of the strange sea to the proton spin structure. This study is feasible with semi-inclusive deep inelastic scattering of electrons off proton and deuteron targets in Hall B at Jefferson Lab. To achieve the desired precision, a Ring Imaging CHerenkov (RICH) detector was built so pion, kaon and proton identification is well performed in the momentum range of 3 to 8 GeV/c. The experimental method and projected precision of the measurements of the parton distributions using Kaon SIDIS will be discussed and the status of the recently built Hybrid RICH detector will be presented.
The visible world is founded on the proton, the only composite building block of matter that is stable in nature. Consequently, understanding the formation of matter relies on explaining the dynamics ...and the properties of the proton's bound state.A fundamental property of the proton involves the response of the system to an external electromagnetic field. It is characterized by the electromagnetic polarizabilities that describe how easily the charge and magnetization distributions inside the system are distorted by the electromagnetic field. Moreover, the generalized polarizabilities map out the resulting deformation of the densities in a proton subject to an electromagnetic field. They disclose essential information about the underlying system dynamics and provide a key for decoding the proton structure in terms of the theory of the strong interaction that binds its elementary quark and gluon constituents. Of particular interest is a puzzle in the electric generalized polarizability of the proton that remains unresolved for two decades. Here we report measurements of the proton's electromagnetic generalized polarizabilities at low four-momentum transfer squared. We show evidence of an anomaly to the behaviour of the proton's electric generalized polarizability that contradicts the predictions of nuclear theory and derive its signature in the spatial distribution of the induced polarization in the proton. The reported measurements suggest the presence of a new, not-yet-understood dynamical mechanism in the proton and present notable challenges to the nuclear theory.
We propose to use the High Momentum Spectrometer of Hall C combined with the Neutral Particle Spectrometer (NPS) to perform high precision measurements of the Deeply Virtual Compton Scattering (DVCS) ...cross section using a beam of positrons. The combination of measurements with oppositely charged incident beams is the only unambiguous way to disentangle the contribution of the DVCS\(^2\) term in the photon electroproduction cross section from its interference with the Bethe-Heitler amplitude. This provides a stronger way to constrain the Generalized Parton Distributions of the nucleon. A wide range of kinematics accessible with an 11 GeV beam off an unpolarized proton target will be covered. The \(Q^2-\)dependence of each contribution will be measured independently.
Les cancers différenciés de la thyroïde (CDT) sont rares. Ils se caractérisent par une évolution lente avec possibilité de métastases à distance, ce qui rend le pronostic défavorable. La ...thyroglobuline (Tg) est le marqueur fiable pour le suivi des CDT.
Évaluation de l’irathérapie dose ablative sur la cinétique de la Tg chez les patients métastatiques en défreination.
Il s’agit d’une étude rétrospective descriptive sur 7 ans portant sur 28 patients, suivis pour un CDT avec un statut M initial connu à l’anatomopathologie et/ou à la scintigraphie post 1ère cure thérapeutique dans le service de médecine nucléaire du CHU Hassan II de Fès.
L’âge moyen au diagnostic était de 54,3 ans, un sex-ratio à 0,17 avec prédominance féminine. Les CPT représentaient 65 % des cas. L’atteinte ganglionnaire est retrouvée dans 53,5 % des cas (atteinte massive dans 6 %). Le statut M1 initial est retrouvé dans 71 % et 28,5 % des cas à la scintigraphie post 1ère cure. Tous les patients ont reçu au moins 2 cures à 3,7 GBq avec une moyenne de 1 à 4 cures. Les principaux sites métastatiques étaient pulmonaires et osseux dans 78,5 et 50 % des cas. Ces atteintes restaient quasi constantes entre les cures sans nette régression. Le taux moyen de Tg entre la 1re et la 4e cure était, respectivement, de 665,3ng/mL et 774,66ng/mL. Une cinétique de Tg croissante a été observée dans 71,4 % des cas après au moins 4 cures d’irathérapie. La cinétique décroissante était observée dans 21,4 % des cas sans tendance à la négativation. Actuellement, 23 patients sont en suivi en oncologie médicale vu leur caractère réfractaire à l’iode 131. Notre série se rapproche des autres séries en ce qui est de l’âge moyen au diagnostic, le sex-ratio, le type de carcinome retrouvé, l’extension ganglionnaire (N. Meziani-Bettayeb et al., 2020 ; M.M. Larwanou et al., 2017), le site osseux métastatique (N. Meziani-Bettayeb et al., 2020), le statut M1 initial (M.M. Larwanou et al., 2017), l’évolution de la cinétique des Tg entre les cures en lien avec le tissu tumoral (R. Sfar et al., 2013 ; H. Phama et al., 2013).
L’irathérapie semble ne pas avoir un impact positif sur la cinétique de Tg chez les patients à risque élevé initialement métastatiques, quel que soit le type histologique. L’évaluation du statut ganglionnaire ou métastatique initial peut être prédictive de la réponse initiale au traitement. La Tg reste le meilleur outil de dépistage de tissu tumoral.
Nowadays, proteins from different plant materials are used to produce Maillard reaction products (MRPs). In this study, antimicrobial, antioxidant and sensory properties of Maillard reaction products ...(MRPs) derived from three plant materials namely sunflower (SF), soybean (SB) and corn (CN) meals were investigated. These MRPs were prepared by mixing each protein hydrolysate (60 g), with xylose (0.595 g) and cysteine (0.372 g) at pH of 7.4, and then heated at 120 °C for 2 h. Results revealed that only SF-MRPs show an antimicrobial effect against tested strains (Staphylococcus aureus and E. coli). SF-MRPs showed greater antioxidant activity followed by SB-MRPs and CN-MRPs. Additionally, CN-MRPs showed higher umami, continuity and mouthfulness sensory attributes compared to SF-MRPs and SB-MRPs. It is therefore deduced that SF-MRPs could be used as potential food ingredients in food products due to their relatively high antimicrobial and antioxidant activities. On the other hand, SF-MRPs could potentially be used as functional food, which could be of great potential for food industries.
•Methods of antioxidant and antimicrobial activity evaluation were proposed.•Antioxidant and antimicrobial activities of three MRPs were evaluated.•Sunflower, soybean and corn MRPs showed all showed antioxidant activities.•Only sunflower MRPs exhibited antimicrobial effect against tested strains.
The contamination of soil with organic pollutants has been accelerated by agricultural and industrial development and poses a major threat to global ecosystems and human health. Various chemical and ...physical techniques have been developed to remediate soils contaminated with organic pollutants, but challenges related to cost, efficacy, and toxic byproducts often limit their sustainability. Fortunately, phytoremediation, achieved through the use of plants and associated microbiomes, has shown great promise for tackling environmental pollution; this technology has been tested both in the laboratory and in the field. Plant-microbe interactions further promote the efficacy of phytoremediation, with plant growth-promoting bacteria (PGPB) often used to assist the remediation of organic pollutants. However, the efficiency of microbe-assisted phytoremediation can be impeded by (i) high concentrations of secondary toxins, (ii) the absence of a suitable sink for these toxins, (iii) nutrient limitations, (iv) the lack of continued release of microbial inocula, and (v) the lack of shelter or porous habitats for planktonic organisms. In this regard, biochar affords unparalleled positive attributes that make it a suitable bacterial carrier and soil health enhancer. We propose that several barriers can be overcome by integrating plants, PGPB, and biochar for the remediation of organic pollutants in soil. Here, we explore the mechanisms by which biochar and PGPB can assist plants in the remediation of organic pollutants in soils, and thereby improve soil health. We analyze the cost-effectiveness, feasibility, life cycle, and practicality of this integration for sustainable restoration and management of soil.
Jingjing Yuan,1,2,* Zenghui Liang,1,* Muhoza Bertrand Geoffrey,1 Yanle Xie,1,2 Shuhan Chen,1,2 Jing Liu,1,2 Yuzhong Xia,1 Huixin Li,1 Yanling Zhao,1 Yuanyuan Mao,1,2 Na Xing,1,2 Jianjun Yang,1,2 ...Zhongyu Wang,1 Fei Xing1,2 1Department of Anesthesiology, Pain and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China; 2Henan Province International Joint Laboratory of Pain, Cognition and Emotion, Zhengzhou, Henan Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei Xing; Zhongyu Wang, Department of Anesthesiology, Pain and Perioperative Medicine, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road Erqi District, Zhengzhou City, Henan Province, People’s Republic of China, Tel +86-15936275656, Email fccxingf@zzu.edu.cn; wzy781217@163.comPurpose: Explore the median effective dose of ciprofol for inducing loss of consciousness in elderly patients and investigate how frailty influences the ED50 of ciprofol in elderly patients.Patients and Methods: A total of 26 non-frail patients and 28 frail patients aged 65– 78 years, with BMI ranging from 15 to 28 kg/m2, and classified as ASA grade II or III were selected. Patients were divided into two groups according to frailty: non-frail patients (CFS< 4), frail patients (CFS≥ 4). With an initial dose of 0.3 mg/kg for elderly non-frail patients and 0.25 mg/kg for elderly frail patients, using the up-and-down Dixon method, and the next patient’s dose was dependent on the previous patient’s response. Demographic information, heart rate (HR), oxygen saturation (SpO2), mean blood pressure (MBP), and bispectral index (BIS) were recorded every 30 seconds, starting from the initiation of drug administration and continuing up to 3 minutes post-administration. Additionally, the total ciprofol dosage during induction, occurrences of hypotension, bradycardia, respiratory depression, and injection pain were recorded.Results: The calculated ED50 (95% confidence interval CI) and ED95 (95% CI) values for ciprofol-induced loss of consciousness were as follows: 0.267 mg/kg (95% CI 0.250– 0.284) and 0.301 mg/kg (95% CI 0.284– 0.397) for elderly non-frail patients; and 0.263 mg/kg (95% CI 0.244– 0.281) and 0.302 mg/kg (95% CI 0.283– 0.412) for elderly frail patients. Importantly, no patients reported intravenous injection pain, required treatment for hypotension, or experienced significant bradycardia.Conclusion: Frailty among elderly patients does not exert a notable impact on the median effective dose of ciprofol for anesthesia induction. Our findings suggest that anesthesiologists may forego the necessity of dosage adjustments when administering ciprofol for anesthesia induction in elderly frail patients.Keywords: ciprofol, median effective dose, elderly patients, frailty, loss of consciousness
Little is known about penile high-risk HPV among MSM in low-and-middle income countries. We aimed to determine the incidence, clearance and persistence of penile hrHPV among Rwandan MSM.
We enrolled ...350 MSM (345 with valid HPV results), aged ≥18 years, at each visit (6-12 months apart), we collected penile PreservCyt specimens and blood for HPV and HIV testing, socio-demographic and behavioral variables. HPV testing was performed using the Ampfire assay. Penile hrHPV incidence and clearance/1,000 person-months of follow-up (PMF), prevalent- and incident-persistence were computed and compared by HIV status.
The mean age was 27.7 ± 6.7 years and 19.4% were living with HIV. Penile hrHPV incidence was 34.8 (95% CI: 29.1, 41.8)/1,000 PMF. HPV16 (11.7, CI 9.26, 14.9) and HPV59 (6.1, CI 4.52, 8.39) had the highest incidence rates. Prevalent- and incident-persistence were 47.5% and 46.6%, respectively. HPV66 (33.3%), HPV52 (30.8%) and HPV16 (29.2%) had the highest prevalent-persistence and HPV33 (53.8%), HPV31 (46.7%) and HPV16 (42.6%) the highest incident-persistence. No differences were found by HIV status except for HPV45 (higher in MSM with HIV).
We found high incidence and prevalent/incident-persistence of penile hrHPV among Rwandan MSM. This highlights the importance of preventive strategies for HPV-associated anogenital cancers.
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