Fall armyworm,
Spodopterafrugiperda
, is a crop pest native to the Americas, which has invaded and spread throughout sub-Saharan Africa within two years. Recent estimates of 20–50% maize yield loss ...in Africa suggest severe impact on livelihoods. Fall armyworm is still infilling its potential range in Africa and could spread to other continents. In order to understand fall armyworm’s year-round, global, potential distribution, we used evidence of the effects of temperature and precipitation on fall armyworm life-history, combined with data on native and African distributions to construct Species Distribution Models (SDMs). We also investigated the strength of trade and transportation pathways that could carry fall armyworm beyond Africa. Up till now, fall armyworm has only invaded areas that have a climate similar to the native distribution, validating the use of climatic SDMs. The strongest climatic limits on fall armyworm’s year-round distribution are the coldest annual temperature and the amount of rain in the wet season. Much of sub-Saharan Africa can host year-round fall armyworm populations, but the likelihoods of colonising North Africa and seasonal migrations into Europe are hard to predict. South and Southeast Asia and Australia have climate conditions that would permit fall armyworm to invade. Current trade and transportation routes reveal Australia, China, India, Indonesia, Malaysia, Philippines and Thailand face high threat of fall armyworm invasions originating from Africa.
Abstract Emotional hardcore and other music genres featuring screamed vocals are puzzling for the appreciator. The typical fan attaches appreciative value to musical screams of emotional pain, all ...the while acknowledging it would be inappropriate to hold similar attitudes towards their sonically similar everyday counterpart: actual human screaming. Call this the screamed vocals problem. To solve the problem, I argue we must attend to the anti-sublimating aims that get expressed in the emotional hardcore vocalist’s choice to scream the lyrics. Screamed vocals help us see the value in rejecting (a) restrictive social norms of emotional expressiveness and (b) restrictive artistic norms about how one ought to express or represent pain in art—namely that if one is going to do so, one must ensure the pain has been ‘beautified’. In developing this second point, I argue that emotional hardcore is well-suited (although not individually so) for putting pressure on longstanding views in the history of aesthetics about the formal relationship between art and human pain.
This paper examines the roles that self-knowledge and reflection play in Schopenhauer's view of agency. Focusing in particular on the discussion of the acquired character, his cognitive theory of ...motivation, and the idea of intellectual freedom, I argue that we find two conceptions of rational agency in Schopenhauer. The 'minimal' conception sees rational agency primarily as a kind of reflective motivation, whereas the 'maximal' or 'robust' conception sees rational agency as involving a kind of reflective self-organization. Furthermore, I argue that rational self-organization and acquired character go hand-in-hand: it is only in virtue of achieving the latter that one achieves the former. Although some worry that the discussion of acquired character does not sit well with Schopenhauer's broader determinist theory of action, the reading offered here aims to demonstrate that the two are reconcilable.
Abstract
We present James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) integral-field spectroscopy of the nearby merging, luminous infrared galaxy, NGC 7469. This galaxy hosts a Seyfert ...type-1.5 nucleus, a highly ionized outflow, and a bright, circumnuclear star-forming ring, making it an ideal target to study active galactic nucleus (AGN) feedback in the local universe. We take advantage of the high spatial/spectral resolution of JWST/MIRI to isolate the star-forming regions surrounding the central active nucleus and study the properties of the dust and warm molecular gas on ∼100 pc scales. The starburst ring exhibits prominent polycyclic aromatic hydrocarbon (PAH) emission, with grain sizes and ionization states varying by only ∼30%, and a total star formation rate of 10–30
M
⊙
yr
−1
derived from fine structure and recombination emission lines. Using pure rotational lines of H
2
we detect 1.2 × 10
7
M
⊙
of warm molecular gas at a temperature higher than 200 K in the ring. All PAH bands get significantly weaker toward the central source, where larger and possibly more ionized grains dominate the emission, likely the result of the ionizing radiation and/or the fast wind emerging from the AGN. The small grains and warm molecular gas in the bright regions of the ring however display properties consistent with normal star-forming regions. These observations highlight the power of JWST to probe the inner regions of dusty, rapidly evolving galaxies for signatures of feedback and inform models that seek to explain the coevolution of supermassive black holes and their hosts.
The central claim of Schopenhauer’s account of human motivation is that ‘cognition is the medium of motives’. In light of motivation’s cognitively mediated structure, he contends that human beings ...are caused to act by ‘mere 'thoughts'’, what he refers to metaphorically as ‘fine, invisible threads’. Despite this avowedly intellectualist handling of the subject, some commentators remain convinced that Schopenhauer is best read as accepting the ‘Humean truism’ that reason alone never motivates; rather, motivation always has its source in desire together with instrumental belief (Young 1987). Here, I raise some doubts for the Humean reading by arguing that it does not take sufficient account of the transformative effects of cognitive mediation, effects which support cases of non-desiderative motivation. I argue in particular that Schopenhauer permits cases of motivation by the essentially cognitive states of imagination and recognition. Tracing this intellectualist strand in Schopenhauer’s view of motivation has two important results. First, it unmasks an important structural role for 'Besonnenheit' (reflectiveness) in his account of practical agency, thereby revealing a unified thread running throughout his system; second, we alight on a possible ‘expressivist’ picture of his account of motivation, something it shares with his broader theory of action.
Gold nanorods have received tremendous attention in recent years due to their exciting potential applications in chemical sensing, biological imaging, drug delivery and phototherapeutics. A ...seed-mediated growth procedure in aqueous solution has been developed to produce these colloidal materials in reasonable quantities, with tunable shape. Details of the reaction chemistry, role of impurity ions, and their influence on the final product shape are still under debate. Subsequent chemistry on preformed nanorods can yield a variety of new shapes and functionalities for numerous applications.
Display omitted
► Gold nanorods have multiple growth patterns depending on the synthetic method. ► Small amounts of metal ions greatly influence growth. ► It is possible to sculpt nanorods post-synthesis to produce new shapes.
Vegetation community composition and the above- and below-ground invertebrate communities are linked intrinsically, though few studies have assessed the impact of non-native plants on both these ...parts of the community together. We evaluated the differences in the above- (foliage- and ground-dwelling) and below-ground invertebrate communities in nine uninvaded plots and nine plots invaded by the annual invasive species Impatiens glandulifera, in the UK during 2007 and 2008. Over 139,000 invertebrates were identified into distinct taxa and categorised into functional feeding groups. The impact of I. glandulifera on the vegetation and invertebrate community composition was evaluated using multivariate statistics including principal response curves (PRC) and redundancy analysis (RDA). In the foliage-dwelling community, all functional feeding groups were less abundant in the invaded plots, and the species richness of Coleoptera and Heteroptera was significantly reduced. In the ground-dwelling community, herbivores, detritivores, and predators were all significantly less abundant in the invaded plots. In contrast, these functional groups in the below-ground community appeared to be largely unaffected, and even positively associated with the presence of I. glandulifera. Although the cover of I. glandulifera decreased in the invaded plots in the second year of the study, only the below-ground invertebrate community showed a significant response. These results indicate that the above- and below-ground invertebrate communities respond differently to the presence of I. glandulifera, and these community shifts can potentially lead to a habitat less biologically diverse than surrounding native communities; which could have negative impacts on higher trophic levels and ecosystem functioning.
The BIOCAT database of introductions of insect biological control agents for the control of insect pests was updated to the end of 2010 to include 6158 introductions, using 2384 different insect ...biological control agents against 588 pest species in 148 countries. Of the introductions, 2007 (32.6 %) led to establishment, and 620 (10.1 %) resulted in satisfactory control being reported against 172 (29.3 %) different pest species. The number of introductions has decreased each decade since the 1970s, but in the same period a higher proportion of introductions became established and contributed to successful control of target pests, and the number of countries implementing classical biological control increased. These positive trends reflect the greater research effort now made to optimize the chances of successful outcomes and increased confidence in classical biological control as a viable pest management strategy against a backdrop of a risk-averse culture that has developed in some key countries in recent years.
Abstract
We have used the Mid-InfraRed Instrument (MIRI) on the James Webb Space Telescope (JWST) to obtain the first spatially resolved, mid-infrared images of
IIZw096
, a merging luminous infrared ...galaxy (LIRG) at
z
= 0.036. Previous observations with the Spitzer Space Telescope suggested that the vast majority of the total IR luminosity (
L
IR
) of the system originated from a small region outside of the two merging nuclei. New observations with JWST/MIRI now allow an accurate measurement of the location and luminosity density of the source that is responsible for the bulk of the IR emission. We estimate that 40%–70% of the IR bolometric luminosity, or 3–5 × 10
11
L
⊙
, arises from a source no larger than 175 pc in radius, suggesting a luminosity density of at least 3–5 × 10
12
L
⊙
kpc
−2
. In addition, we detect 11 other star-forming sources, five of which were previously unknown. The MIRI F1500W/F560W colors of most of these sources, including the source responsible for the bulk of the far-IR emission, are much redder than the nuclei of local LIRGs. These observations reveal the power of JWST to disentangle the complex regions at the hearts of merging, dusty galaxies.
Kinase/phosphatase balance governs cardiac excitability in health and disease. Although detailed mechanisms for cardiac kinase regulation are established, far less is known regarding cardiac protein ...phosphatase 2A (PP2A) regulation. This is largely due to the complexity of the PP2A holoenzyme structure (combinatorial assembly of three subunit enzyme from >17 subunit genes) and the inability to segregate “global” PP2A function from the activities of multiple “local” holoenzyme populations. Here we report that PP2A catalytic, regulatory, and scaffolding subunits are tightly regulated at transcriptional, translational, and post-translational levels to tune myocyte function at base line and in disease. We show that past global read-outs of cellular PP2A activity more appropriately represent the collective activity of numerous individual PP2A holoenzymes, each displaying a specific subcellular localization (dictated by select PP2A regulatory subunits) as well as local specific post-translational catalytic subunit methylation and phosphorylation events that regulate local and rapid holoenzyme assembly/disassembly (via leucine carboxymethyltransferase 1/phosphatase methylesterase 1 (LCMT-1/PME-1). We report that PP2A subunits are selectively regulated between human and animal models, across cardiac chambers, and even within specific cardiac cell types. Moreover, this regulation can be rapidly tuned in response to cellular activation. Finally, we report that global PP2A is altered in human and experimental models of heart disease, yet each pathology displays its own distinct molecular signature though specific PP2A subunit modulatory events. These new data provide an initial view into the signaling pathways that govern PP2A function in heart but also establish the first step in defining specific PP2A regulatory targets in health and disease.
Background: PP2A regulates cardiac excitability and physiology.
Results: PP2A regulation in heart occurs through integrative transcriptional, translational, and post-translational control of three classes of subunits (17 genes) to control holoenzyme synthesis, localization, and maintenance; pathways are mechanistically altered in heart disease.
Conclusion: Multiple mechanisms are present for acute and chronic regulation of specific PP2A populations.
Significance: Results provide molecular insight into cardiac PP2A regulation.
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