Introduction
The impact of conditions that partly or indirectly contribute to drinking‐related mortality is usually underestimated. We investigate all alcohol‐related multiple (underlying and ...contributory) causes of death and compare mortality distributions in countries with different levels and patterns of drinking.
Method
Analysis of population‐level mortality data for persons aged 20 and over in Austria, Czechia, Poland and Spain. Age‐standardised death rates and standardised ratios of multiple to underlying cause were calculated for alcohol‐related causes of death.
Results
Multiple‐cause mortality ranged from 20 to 58 deaths per 100,000 for men and from 5 to 16 per 100,000 for women. Liver diseases were the most common underlying and multiple causes, but mental and behavioural disorders were the second or third, depending on country and sex, most prevalent multiple mentions. Two distinct age patterns of alcohol‐related mortality were observed: in Czechia and Poland an inverted‐U distribution with a peak at the age of 60–64, in Austria and Spain a distribution increasing with age and then levelling off for older age groups.
Discussion and Conclusion
The importance of alcohol‐related conditions that indirectly impact mortality can be re‐assessed with the use of contributory mentions. The multiple‐cause‐of‐death approach provides convergent results for countries characterised by similar patterns of alcohol consumption. Multiple‐cause mortality was almost double the level of mortality with alcohol as the underlying cause, except in Poland. Mental and behavioural disorders were mostly certified as contributory to other, non‐alcohol‐related underlying causes of death.
Abstract
Eurostat’s official Healthy Life Years (HLY) estimates are based on European Union Statistics on Income and Living Conditions (EU-SILC) cross-sectional data. As EU-SILC has a rotational ...sample design, the largest part of the samples are longitudinal, health-related attrition constituting a potential source of bias of these estimates. Bland-Altman plots assessing the agreement between pairs of HLY based on total and new rotational, representative samples demonstrated no significant, systematic attrition-related bias. However, the wide limits of agreement indicate considerable uncertainty, larger than accounted for in the confidence intervals of HLY estimates.
Lung cancer is the most common adult malignancy accounting for the largest proportion of cancer related deaths. Iron (Fe) is an essential trace element and is a component of several major metabolic ...pathways playing an important role in many physiological processes. In this study we evaluated the association between Fe concentration in serum, iron metabolism parameters and genetic variaton in 7 genes involved in iron metabolism and anti-oxidative processes with the incidence of lung cancer in Poland.
The study included 200 lung cancer patients and 200 matched healthy control subjects. We analyzed serum iron concentration and iron metabolism parameters (TIBC, UIBC, serum ferritin and transferrin saturation), and genotyped seven variants in seven genes: HFE, TFR1, HAMP, TF, SOD2, CAT and GPX1.
Lung cancer patients compared to their matched controls had significantly higher mean serum iron level (p = 0.01), ferritin level (p = 0.007) and TIBC (p = 0.006). Analysis revealed that higher concentration of iron and ferritin (IVth quartile) compared to the lower concentration (Ist quartile) was associated with over 2-fold increased lung cancer incidence. We also found that higher transferrin saturation (p = 0.01) and lower TIBC (p<0.01) are associated with better survival of lung cancer patients. The analysis of polymorphisms in iron related genes did not reveal a significant difference between lung cancer patients and controls. However, rs10421768 in HAMP showed a borderline statistically significant correlation with lung cancer risk (OR = 2.83, p = 0.05).
The results of this case control study indicate that higher body iron represented by higher Fe and ferritin levels may be associated with lung cancer incidence. Rs10421768 in HAMP may be associated with about 3-times higher lung cancer risk. Higher Fe body content may be associated with better survival of lung cancer patients.
Aims
We assess the effect of smoking on regional disparities in mortality in Poland and its contribution to the change in regional disparities during the last two decades.
Design, Setting and ...Participants
We used population‐level mortality data from the population registry for 379 Nomenclature of Territorial Units for Statistics (NUTS)‐4 Polish regions for 1991–93 and 2008–10.
Measurements
The importance of smoking was assessed by smoking‐attributable mortality (SAM) derived using a simplified indirect Peto‐Lopez method. Regional differences in age‐standardized all‐cause, smoking‐ and non‐smoking‐attributable mortality (NSAM) rates at ages 35 years and over were mapped, and spatial clustering (Moran's I) and coefficients of variation (CV) were estimated. The contribution of SAM to variation in all‐cause mortality was assessed by variance decomposition and compared over time.
Findings
In 2008–10, all‐cause and SAM rates were characterized by a similar pattern of spatial clustering (Moran's I > 0.44, P < 0.0001). For NSAM, a more random pattern with less regional clustering showed (Moran's I = 0.34, P < 0.0001). The contribution of smoking to regional variation was substantial 54%, 95% confidence interval (CI) = 44.9, 62.5 among men; 24.9%, 95% CI = 20.9, 29.1 among women, and compared with 1991–93, 27.5 percentage points lower for men and 6.3 percentage points higher for women. Smoking contributed to the divergence between the regions in all‐cause mortality between 1991–93 and 2008–10 for men increase in CV of SAM by 2% (0, 4%), but not for women decrease in CV of SAM by 15% (22, 10%).
Conclusions
Differences in past smoking behaviour may largely explain the regional differences in all‐cause mortality existing in 2008–10 in Poland, and its trends since 1991–1993.
Prostate cancer is one of the most commonly diagnosed malignancies among men in Western populations. Evidence reported in the literature suggests that zinc may be related to prostate cancer. In this ...study we evaluated the association of serum zinc levels and polymorphisms in genes encoding zinc-dependent proteins with prostate cancer in Poland.
The study group consisted of 197 men affected with prostate cancer and 197 healthy men. Serum zinc levels were measured and 5 single nucleotide polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13, MT2A genes were genotyped.
The mean serum zinc level was higher in prostate cancer patients than in healthy controls (898.9±12.01 μg/l vs. 856.6±13.05 μg/l, p<0.01). When compared in quartiles a significant association of higher zinc concentration with the incidence of prostate cancer was observed. The highest OR (OR = 4.41, 95%CI 2.07-9.37, p<0.01) was observed in 3rd quartile (>853.0-973.9 μg/l). Among five analyzed genetic variants, rs11568818 in MMP-7 appeared to be correlated with 2-fold increased prostate cancer risk (OR = 2.39, 95% CI = 1.19-4.82, p = 0.015).
Our results suggest a significant correlation of higher serum zinc levels with the diagnosis of prostate cancer. The polymorphism rs11568818 in MMP-7 gene was also associated with an increased prostate cancer risk in Poland.
This paper deals with the development of dimensional control technology for the production of accessory drive train (ADT) gearbox housing, according to the closed door technology approach. The work ...presents the methodology of the final inspection of bearing seat position deviation by replacing the coordinate measuring machines (CMMs) with a computerized numerical control (CNC) machine and adaptive neuro-fuzzy inference system. The results of the work indicated that correct solutions were obtained. In addition, the technological process of manufacturing is fully automated and performed entirely on the production line.
Knowledge about the potential effects of stressful events on smoking cessation is helpful for the design of health interventions. Previous studies on this topic tended to group together adults of all ...ages and of both genders. We investigate the contribution of marital and employment losses on smoking cessation by gender, specifically among older adults in Europe. We used panel data from waves 4 (2011) and 5 (2013) of the Survey of Health, Ageing and Retirement in Europe for 3345 male and 3115 female smokers at baseline aged 50 and over from 13 countries. The associations between marital and employment losses and smoking cessation were derived from logistic regression models for each gender, controlling for age, educational attainment, diseases incidence and country of residence. Interactions between gender and marital and employment losses were tested. Over the analysed period, 119 smokers became widowed or divorced (1.8 %), 318 became retired (4.9 %) and 100 became unemployed (1.5 %). Becoming widowed or divorced was associated with lower probability of smoking cessation among both men (OR 0.36, 95 % CI 0.14–0.94) and women (OR 0.46, 95 % CI 0.21–0.99). Transitions to unemployment and to retirement were not significantly associated with smoking cessation (OR 0.62, 95 % CI 0.25–1.49; and OR 0.68, 95 % CI 0.43–1.07, respectively). Gender differences in the association between marital and employment losses and smoking cessation were not statistically significant (
p
value > 0.05 for all interactions). Health interventions should take into account that male and female older adults affected by marital loss are at risk of continuing smoking.
The goal of this book is simple: We would like to show how mortality dynamics can be visualized in the so-called Lexis diagram. To appeal to as many potential readers as possible, we do not require ...any specialist knowledge. This approach may be disappointing: Demographers may have liked more information about the mathematical underpinnings of population dynamics on the Lexis surface as demonstrated, for instance, by Arthur and Vaupel in 1984. Statisticians would have probably preferred more information about the underlying smoothing methods that were used. Epidemiologists likewise might miss discussions about the etiology of diseases. Sociologists would have probably expected that our results were more embedded into theoretical frameworks...
It has been suggested that selenium deficiency is a risk factor for several cancer types. We conducted a case-control study in Szczecin, a region of northwestern Poland, on 95 cases of lung cancer, ...113 cases of laryngeal cancer and corresponding healthy controls.
We measured the serum level of selenium and established genotypes for four variants in four selenoprotein genes (GPX1, GPX4, TXNRD2 and SEP15). Selenium levels in the cases were measured after diagnosis but before treatment. We calculated the odds of being diagnosed with lung or laryngeal cancer, conditional on selenium level and genotype.
Among lung cancer cases, the mean selenium level was 63.2 µg/l, compared to a mean level of 74.6 µg/l for their matched controls (p<0.0001). Among laryngeal cancer cases, the mean selenium level was 64.8 µg/l, compared to a mean level of 77.1 µg/l for their matched controls (p<0.0001). Compared to a serum selenium value below 60 µg/l, a selenium level above 80 µg/l was associated with an odds ratio of 0.10 (95% CI 0.03 to 0.34; p = 0.0002) for lung cancer and 0.23 (95% CI 0. 09 to 0.56; p = 0.001) for laryngeal cancer. In analysis of four selenoprotein genes we found a modest evidence of association of genetic variant in GPX1 with the risk of lung and laryngeal cancers.
A selenium level below 60 µg/l is associated with a high risk of both lung and laryngeal cancer.
Lung cancer is the leading cause of cancer-related death worldwide. Exposure to environmental and occupational carcinogens is an important cause of lung cancer. One of these substances is chromium, ...which is found ubiquitously across the planet. The International Agency for Research on Cancer has classified chromium(VI) as a human carcinogen. The aim of this study was to assess whether serum chromium levels, as well as DNA variants in selected genes involved in carcinogenesis, xenobiotic-metabolism, and oxidative stress could be helpful in the detection of lung cancer. We conducted a study using 218 lung cancer patients and 218 matched healthy controls. We measured serum chromium levels and genotyped ten genetic variants in
ERCC2
,
XRCC1
,
MT1B
,
GSTP1
,
ABCB1
,
NQ01
,
CRTC3
,
GPX1
,
SOD2
and
CAT
. The odds ratios of being diagnosed with lung cancer were calculated using conditional logistic regression with respect to serum chromium level and genotypes. The odds ratio for the occurrence of lung cancer increased with increasing serum chromium levels. The difference between the quartiles with the lowest vs. highest chromium level was more than fourfold in the entire group (OR 4.52, CI 2.17–9.42,
p
< 0.01). This correlation was significantly increased by more than twice when specific genotypes were taken into consideration (
ERCC
–rs12181 TT, OR 12.34, CI 1.17–130.01,
p
= 0.04;
CRTC3
–rs12915189 non GG, OR 9.73, CI 1.58–60.10,
p
= 0.01;
GSTP1
–rs1695 non AA, OR 9.47, CI 2.06–43.49,
p
= < 0.01;
CAT
–rs1001179 non CC, OR 9.18, CI 1.64–51.24,
p
= 0.01). Total serum chromium levels > 0.1 μg/L were correlated with 73% (52/71) of lung cancers diagnosed with stage I disease. Our findings support the role of chromium and the influence of key proteins on lung cancer burden in the general population.
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