The monograph examines the development of interwar Hungarian cultural diplomacy in three areas: academia, the tourist industry, and motion picture and radio production. It is a story of how Hungarian ...elites perceived—and misperceived—themselves, their surroundings, and their own ability to affect the country’s fate amid high hopes and deepseated anxieties about the country’s place in a Europe newly reconstructed after World War I. Though the study is rooted in Hungary, it explores the dynamic and contingent relationship between identity construction and transnational cultural and political currents in small EastCentral European nations in the interwar period.
The predictable answer to the provocative question of whether programmable freezers are still needed in the embryo laboratory is an even more provocative ‘no’. However, such a radical statement needs ...strong support. Based on the extensive literature of the past 5 years, the authors collected arguments either supporting or contradicting their opinion. After an overview of the causes of cryoinjuries and strategies to eliminate them, the evolution of vitrification methods is discussed. Special attention is paid to the biosafety issues. The authors did not find any circumstance in oocyte or embryo cryopreservation where slow freezing offers considerable advantages compared with vitrification. In contrast, the overwhelming majority of published data prove that the latest vitrification methods are more efficient and reliable than any version of slow freezing. Application of the proper vitrification methods increases the efficiency of long-term storage of stem cells and opens new perspectives in cryopreservation of oocytes, both for IVF and somatic cell nuclear transfer. However, lack of support from regulatory authorities, and conservative approachs regarding novel techniques can slow down the implementation of vitrification. The opinion of the authors is that vitrification is the future of cryopreservation. The public have the final say in whether they want and allow this future to arrive.
Artificial Intelligence and Machine Learning Fundamentals teaches you machine learning and neural networks from the ground up using real-world examples. After you complete this book, you will be ...excited to revamp your current projects or build new intelligent networks.
Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase δ and γ (PI3K-δ,γ) being developed for treatment of hematologic malignancies. PI3K-δ,γ signaling can ...promote B-cell proliferation and survival in clonal B-cell malignancies, such as chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). In a phase 1 study, duvelisib showed clinically meaningful activity and acceptable safety in CLL/SLL patients. We report here the results of DUO, a global phase 3 randomized study of duvelisib vs ofatumumab monotherapy for patients with relapsed or refractory (RR) CLL/SLL. Patients were randomized 1:1 to oral duvelisib 25 mg twice daily (n = 160) or ofatumumab IV (n = 159). The study met the primary study end point by significantly improving progression-free survival per independent review committee assessment compared with ofatumumab for all patients (median, 13.3 months vs 9.9 months; hazard ratio HR = 0.52; P < .0001), including those with high-risk chromosome 17p13.1 deletions del(17p) and/or TP53 mutations (HR = 0.40; P = .0002). The overall response rate was significantly higher with duvelisib (74% vs 45%; P < .0001) regardless of del(17p) status. The most common adverse events were diarrhea, neutropenia, pyrexia, nausea, anemia, and cough on the duvelisib arm, and neutropenia and infusion reactions on the ofatumumab arm. The DUO trial data support duvelisib as a potentially effective treatment option for patients with RR CLL/SLL. This trial was registered at www.clinicaltrials.gov as #NCT02004522.
•Duvelisib significantly improved progression-free survival and overall response rates compared with ofatumumab in RR CLL/SLL patients.•Duvelisib's efficacy and manageable safety profile support its consideration as a novel, oral monotherapy for RR CLL/SLL patients.
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This paper proposes new methods to assess the myopic loss aversion premium (the expected return-differential) based on an experimental design by eliciting both willingness-to-pay and allocation ...percentage figures and also by inferring and comparing absolute risk aversion coefficients. Our results indicate a high level of loss aversion and support the existence of the myopic loss aversion bias.
Neuronal circuit asymmetries are important components of brain circuits, but the molecular pathways leading to their establishment remain unknown. Here we found that the mutation of FRMD7, a gene ...that is defective in human congenital nystagmus, leads to the selective loss of the horizontal optokinetic reflex in mice, as it does in humans. This is accompanied by the selective loss of horizontal direction selectivity in retinal ganglion cells and the transition from asymmetric to symmetric inhibitory input to horizontal direction-selective ganglion cells. In wild-type retinas, we found FRMD7 specifically expressed in starburst amacrine cells, the interneuron type that provides asymmetric inhibition to direction-selective retinal ganglion cells. This work identifies FRMD7 as a key regulator in establishing a neuronal circuit asymmetry, and it suggests the involvement of a specific inhibitory neuron type in the pathophysiology of a neurological disease.
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•FRMD7 is required for the horizontal optokinetic reflex in mice as in humans•Horizontal direction selectivity is lost in the retina of FRMD7 mutant mice•Asymmetry of inhibitory inputs to horizontal DS cells is lost in FRMD7 mutant mice•FRMD7 is expressed in ChAT-expressing cells in the retina of mice and primates
Yonehara et al. show that FRMD7, a gene that is defective in human congenital nystagmus, is required in the mouse retina to establish spatially asymmetric inhibitory inputs from starburst cells to horizontal direction-selective ganglion cells.
Intraoral scanner (IOS) accuracy is commonly evaluated using full-arch surface comparison, which fails to take into consideration the starting position of the scanning (scan origin). Previously a ...novel method was developed, which takes into account the scan origin and calculates the deviation of predefined identical points between references and test models. This method may reveal the error caused by stitching individual images during intraoral scan. This study aimed to validate the novel method by comparing the trueness of seven IOSs (Element 1, Element 2, Emerald, Omnicam, Planscan, Trios 3, CS 3600) to a physical impression digitized by laboratory scanner which lacks linear stitching problems.
Digital test models of a dentate human cadaver maxilla were made by IOSs and by laboratory scanner after polyvinylsiloxane impression. All scans started on the occlusal surface of the tooth #15 (universal notation, scan origin) and finished at tooth #2. The reference model and test models were superimposed at the scan origin in GOM Inspect software. Deviations were measured between identical points on three different axes, and the complex 3D deviation was calculated. The effect of scanners, tooth, and axis was statistically analyzed by the generalized linear mixed model.
The deviation gradually increased as the distance from scan origin increased for the IOSs but not for the physical impression. The highest deviation occurred mostly at the apico-coronal axis for the IOSs. The mean deviation of the physical impression (53 ± 2 μm) was not significantly different from the Trios 3 (156 ± 8 μm) and CS 3600 (365 ± 29 μm), but it was significantly lower than the values of Element 1 (531 ± 26 μm), Element 2 (246 ± 11 μm), Emerald (317 ± 13 μm), Omnicam (174 ± 11 μm), Planscan (903 ± 49 μm).
The physical impression was superior compared to the IOSs on dentate full-arch of human cadaver. The novel method could reveal the stitching error of IOSs, which may partly be caused by the difficulties in depth measurement.
Home bias in investments (a major puzzle in international economics) is important because it can lead to inefficient portfolios, reduction of international trade, and exacerbation of financial ...contagion. In contrast, flight-to-quality (FTQ) acts to intensify international investments. We examine relationships between these two contrary phenomena in normal market conditions and exceptional periods, such as the 2008–2009 financial crisis, the 2013 taper tantrum episode, and the 2020 Covid-19 crisis in Group of Seven (G7) countries from 2004 to 2021. We apply a multivariate panel regression framework, using dynamic conditional correlations as measures of FTQ and multiple, robust specifications for the bias measure. Our findings indicate a positive relationship between home allocation and FTQ, this flight being oriented toward safe domestic assets. This result is surprising as it shows that home bias can have a beneficial side, as it can, by orienting safety-seeking investments domestically, counteract somewhat the aggravation of FTQ.
•We analyze relationships between home bias and flight-to-quality in the G7 markets.•We examine this relationship in normal market conditions and exceptional periods.•A positive relationship exists between home allocation and flight-to-quality.•Flight-to-quality occurs on a domestic level rather than internationally.•Home bias can counteract the aggravation of flight-to-quality.
The present questionnaire-based study combines and expands technology acceptance and behavioural (risk and loss aversion) variables in explaining the demand for life insurance products. Loss aversion ...is inversely related to the proxy for life insurance demand and two technology acceptance related factors (usefulness of online technology and acceptance of smart devices) have a significant positive influence.
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