The authors propose using interactive and multisensory interfaces to design user
behavior change. For this purpose, they used coauthor Nikolic's interactive art
installation
, created to provoke
...health-care-related behavioral changes by arousing death anxiety. Visitors are
invited to undertake a (fake) medical examination by interacting with the
installation's human heart-shaped interface. Research outcomes are presented
based on visitors' observations and participant responses in interviews after
interacting with the installation.
In this paper, we were discussing designed processes in prototyping In-Visible Island: Inclusive Storytelling Platform for Visually Impaired Children to contribute ways in accelerating their social ...learning curve, which coincidentally, it will also have a role in educating sighted children to have more empathy towards of their peers physical limitation by improving interactions, understanding and communication between these groups. We designed this novel system to achieve common multi-sensory user experience between groups of users with different physical preferences by using tactile and sound simulations, common elements of realities for both groups, as essential for users’ experience design. We assumed that this playful collaboration could lead to positive social interactions between peers and help visually-impaired children in social skills development in the early stage as well as improve the social competences of both groups.
Quantitative structure–activity relationships (QSAR) have been established for two sets of the antitumor drugs, α-tocopherol derivatives. Constitutional, geometrical, physico-chemical and electronic ...descriptors (using the B3LYP/6-31G (d, p) basis set) were computed and analyzed. The most relevant of these descriptors were grouped and multiple linear regressions have been carried out. QSAR model with four variables,
R
2
=
0.98 and cross-validation parameter
q
pre
2
=
0.91
, was selected. Analogs of α-tocopherol (compounds D-1 and D-2) have been designed and their antiproliferative activities were evaluated using the proposed regression model.
Calculated antiproliferative activities of the designed lysine/α-tocopherol/cholesterol conjugates, IC
50 (D-1)
=
2.25
μM and IC
50 (D-2)
=
3.42
μM, were significantly stronger than activities of the other analyzed compounds IC
50
>
4
μM.
We introduce the time-dependent density matrix renormalization group (tDMRG) as a solution to a long-standing problem in spintronics—how to describe spin-transfer torque (STT) between flowing spins ...of conduction electrons and localized spins within a magnetic material by treating the dynamics of both spin species fully quantum mechanically. In contrast to conventional Slonczewski-Berger STT, where the localized spins are viewed as classical vectors obeying the Landau-Lifshitz-Gilbert equation and where their STT-driven dynamics is initiated only when the spin polarization of flowing electrons and localized spins are noncollinear, quantum STT can occur when these vectors are collinear but antiparallel. Using tDMRG, we simulate the time evolution of a many-body quantum state of electrons and localized spins, where the former are injected as a spin-polarized current pulse while the latter comprise a quantum Heisenberg ferromagnetic metallic (FM) spin-12XXZchain initially in the ground state with spin polarization antiparallel to that of injected electrons. The quantum STT reverses the direction of localized spins, but without rotation from the initial orientation, when the number of injected electrons exceeds the number of localized spins. Such nonclassical reversal, which is absent from Landau-Lifshitz-Gilbert dynamics, is strikingly inhomogeneous across the FM chain, and it can be accompanied by reduction of the magnetization associated with localized spins, even to zero at specific locations. This feature arises because quantum STT generates a highly entangled nonequilibrium many-body state of all flowing and localized spins, despite starting from the initially unentangled ground state of a mundane FM. Furthermore, the mutual information between localized spins at the FM edges remains nonzero even at infinite separation as the signature of dynamical buildup of long-range entanglement. The growth in time of entanglement entropy differentiates between the quantum and conventional (i.e., noncollinear) setups for STT, reaching a much larger asymptotic value in the former case.
Abstract
Background
Dietary supplements use continues to increase in many countries. They are often used without a full understanding of the potential benefits and risks associated with their use, ...and without consultation with a health care professional. This study aimed to explore health beliefs and patterns of dietary supplement usage among fitness club participants.
Methods
This cross-sectional study was conducted in fitness clubs of the city of Nis, Serbia. Male adults, age 18-45 years, participated. Data from participants were collected through an original structured, self-administered questionnaire describes the prevalence and type of supplements used, the reasons for using and the information source.
Results
The prevalence of dietary supplement intake among participants was 85.86%. Most participants were between the age of 20 and 40 years, had a college degree (57.1%), non-smokers (80.5%), without chronic disease (86%), perform exercise at least thrice weekly (76.2%) and 63% had at least1 hour. The percentage of participants who had favorable health views on dietary supplements was significantly higher among the supplement users than among the non-users (P < 0.0001). Most participants (76.19%) perform exercise from 3 to 5 times weekly and 82.85% had from 1 to 2 hours exercise duration. The percentage of subjects who think supplements have side effects was significantly higher among the supplement non-users than among the users (p < 0 .05). Proteins (83.33%), amino acids (63.09%) and creatine (52.38%) were the most commonly reported supplements used. The places of buying dietary supplements most mentioned were specialized supplement store (78.57%), online (11.9%) and pharmacy (9.52%).
Conclusions
Male fitness club member are large consumers of dietary supplements. Public health campaigns could be useful to educate Serbian population regarding using dietary supplements during fitness activities.
Key messages
Male fitness club members are large consumers of dietary supplements in Serbia. Public health campaigns are needed to educate fitness participants about using dietary supplements.
Channelrhodopsin-2 (ChR2) has become a widely used tool for stimulating neurons with light. Nevertheless, the underlying dynamics of the ChR2-evoked spikes are still not yet fully understood. Here, ...we develop a model that describes the response of ChR2-expressing neurons to light stimuli and use the model to explore the light-to-spike process. We show that an optimal stimulation yield is achieved when the optical energies are delivered in short pulses. The model allows us to theoretically examine the effects of using various types of ChR2 mutants. We show that while increasing the lifetime and shuttering speed of ChR2 have limited effect, reducing the threshold irradiance by increased conductance will eliminate adaptation and allow constant dynamic range. The model and the conclusion presented in this study can help to interpret experimental results, design illumination protocols, and seek improvement strategies in the nascent optogenetic field.
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