The formation of heterodimers (see diagram) in mixtures of glycopeptide antibiotics are investigated by electrospray ionization mass spectrometry (ESI‐MS) and NMR spectroscopy. Dimerization constants ...are determined.
Pneumococcal pneumonia causes significant morbidity and mortality among adults. Given limitations of diagnostic tests for non-bacteremic pneumococcal pneumonia, most studies report the incidence of ...bacteremic or invasive pneumococcal disease (IPD), and thus, grossly underestimate the pneumococcal pneumonia burden. We aimed to develop a conceptual and quantitative strategy to estimate the non-bacteremic disease burden among adults with community-acquired pneumonia (CAP) using systematic study methods and the availability of a urine antigen assay.
We performed a systematic literature review of studies providing information on the relative yield of various diagnostic assays (BinaxNOW® S. pneumoniae urine antigen test (UAT) with blood and/or sputum culture) in diagnosing pneumococcal pneumonia. We estimated the proportion of pneumococcal pneumonia that is bacteremic, the proportion of CAP attributable to pneumococcus, and the additional contribution of the Binax UAT beyond conventional diagnostic techniques, using random effects meta-analytic methods and bootstrapping. We included 35 studies in the analysis, predominantly from developed countries. The estimated proportion of pneumococcal pneumonia that is bacteremic was 24.8% (95% CI: 21.3%, 28.9%). The estimated proportion of CAP attributable to pneumococcus was 27.3% (95% CI: 23.9%, 31.1%). The Binax UAT diagnosed an additional 11.4% (95% CI: 9.6, 13.6%) of CAP beyond conventional techniques. We were limited by the fact that not all patients underwent all diagnostic tests and by the sensitivity and specificity of the diagnostic tests themselves. We address these resulting biases and provide a range of plausible values in order to estimate the burden of pneumococcal pneumonia among adults.
Estimating the adult burden of pneumococcal disease from bacteremic pneumococcal pneumonia data alone significantly underestimates the true burden of disease in adults. For every case of bacteremic pneumococcal pneumonia, we estimate that there are at least 3 additional cases of non-bacteremic pneumococcal pneumonia.
We assessed the effect of cuff inflation of the laryngeal mask airway at removal on sore throat, pharyngeal morbidity and airway complications.
In a prospective randomized trial, we used a ...standardized technique of anesthesia and of laryngeal mask insertion in 126 consecutive day-case patients. Postoperatively, on eye opening, the masks were removed either inflated (Group A) or deflated (Group B) and examined for blood by a blinded observer. Episodes of coughing, gagging, laryngospasm, hiccups and retching, and symptoms of sore throat and hoarseness were recorded by the same observer.
Demographics were similar. Bloodstaining occurred in 21% of patients in Group A (n = 63) vs 13% in Group B (n = 63; P = 0.23); the incidence of sore throat was identical (19%). Group A experienced more hoarseness (22% vs 9%; P = 0.05). Overall airway complications did not differ between groups (19% vs 11%; P = 0.21).
We conclude that removal of the laryngeal mask airway inflated does not reduce the incidence of sore throat, pharyngeal morbidity or airway complications.
Book Reviews (Book Review) O' Brien, James H; Owens, Gary; McIlroy, Brian ...
The Canadian Journal of Irish Studies,
12/1991, Letnik:
17, Številka:
2
Book Review
Optical wireless LANs have the potential to provide bandwidths far in excess of those available with current or planned RF networks. There are several approaches to implementing optical wireless ...systems, but these usually involve the integration of optical, optoelectronic, and electrical components in order to create transceivers. Such systems are necessarily complex, and the widespread use of optical wireless is likely to be dependent on the ability to fabricate the required transceiver components at low cost. A number of UK universities are currently involved in a project to demonstrate integrated optical wireless subsystems that can provide line-of-sight in-building communications at 155 Mb/s and above. The system uses two-dimensional arrays of novel microcavity LED emitters and arrays of detectors integrated with custom CMOS integrated circuits to implement tracking transceiver components. In this article we set out the basic approaches that can be used for in-building optical wireless communication and argue the need for an integrated and scalable approach to the fabrication of transceivers. Our work aimed at implementing these components, including experimental results and potential future directions, is then discussed.
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