Energy consumption reduction is critical in various industrial environments. Machine tool manufacturers could contribute to this matter by developing advanced functions for machines. Power ...consumption of machining center was measured in various conditions. The conclusion was that modifying cutting conditions reduces energy consumption. This applies for either regular drilling, face/end milling or deep hole machining. Also, a new acceleration control method is developed to reduce energy consumption by synchronizing spindle acceleration with feed system. Experiments were performed to verify these methods and promising results were achieved.
Background
Some patients with intellectual disabilities (ID) are prescribed antipsychotic drugs for symptomatic treatment of behavioural disorders. Nevertheless, it can still prove difficult to ...perform dental treatments safely for some patients with ID. In such cases, treatment under intravenous sedation (IVS) is one option. Sedative, hypnotic and α‐blocking effects of antipsychotic drugs may cause adverse events, such as severe hypotension, among patients who take antipsychotic drugs regularly. This study aimed to investigate the effects of oral antipsychotic medication on cardiovascular function during IVS. Accordingly, we compared mean blood pressure (MBP) and heart rate (HR) between patients who regularly take antipsychotic drugs and patients who do not.
Methods
Thirty‐seven patients with ID were enrolled in this study. All participants were outpatients of Special Care Dentistry of general hospital and received dental treatment under IVS performed with a combination of midazolam and propofol. Eighteen patients regularly took antipsychotics (medication group), and 19 patients were not currently taking antipsychotics (non‐medication group). MBP, HR, dose, and effect‐site concentration of intravenous sedative medications were measured at three points: ‘before IVS’, ‘at optimal sedation’, and ‘during dental treatment’.
Results
The magnitude of reduction of MBP was significantly smaller in the medication group than in the non‐medication group (P < 0.023). However, there were no differences in MBP, HR, dose, and effect‐site concentration of midazolam and propofol between groups at any point.
Conclusion
These results suggest that antipsychotic medication may not have clinically significant adverse effects on cardiovascular fluctuations during dental treatment under IVS for persons with ID.
Increasing the silicon content in non-grain-oriented (NO) electrical steel sheets is known to decrease iron loss by changing electrical resistivity and magnetostriction behavior. However, few studies ...on the effect of high silicon contents in grain-oriented (GO) electrical steel have been reported. One of the major differences in the iron loss of GO and NO is that excess eddy current loss, which has a strong relationship with the magnetic domain structure, is more dominant in total iron loss in GO. In this paper, high silicon GO was prepared by the CVD siliconizing method, which has the advantage that the silicon content can be changed without changing the crystal grain size and crystallographic texture of the specimen. It was found that iron loss was reduced as the silicon content was increased, and 6.5 mass% silicon steel showed about half the hysteresis loss of conventional 3 mass% silicon steel, but the eddy current loss in 6.5 mass% silicon steel was equivalent to or slightly larger than that in 3 mass% silicon steel. Magnetic domain observation and calculations suggested that this difference was a result of coarsening of the magnetic domains in the high silicon steel.
Myxoid liposarcoma (MLS) is the second most common subtype of liposarcoma, and metastasis occurs in up to one-third of cases. However, the mechanisms of invasion and metastasis remain unclear. ...Tumour-associated macrophages (TAMs) have important roles in tumour invasion, metastasis, and/or poor prognosis. The aim of this study was to investigate the relationship between TAMs and MLS.
Using 78 primary MLS samples, the association between clinical prognosis and macrophage infiltration was evaluated by immunochemistry. The effects of macrophages on cell growth, cell motility, and invasion of MLS cell lines were investigated in vitro. In addition, clinicopathological factors were analysed to assess their prognostic implications in MLS.
Higher levels of CD68-positive macrophages were associated with poorer overall survival in MLS samples. Macrophage-conditioned medium enhanced MLS cell motility and invasion by activating epidermal growth factor receptor (EGFR), with the key ligand suggested to be heparin-binding EGF-like growth factor (HB-EGF). The phosphoinositide 3-kinase/Akt pathway was mostly involved in HB-EGF-induced cell motility and invasion of MLS. The expression of phosphorylated EGFR in MLS clinical samples was associated with macrophage infiltration. In addition, more significant macrophage infiltration was associated with poor prognosis even in multivariate analysis.
Macrophage infiltration in MLS predicts poor prognosis, and the relationship between TAMs and MLS may be a new candidate for therapeutic targets of MLS.
Sigmoid volvulus and the coffee bean sign Kadoya, Y; Kenzaka, T; Oda, Y ...
QJM : An International Journal of Medicine,
01/2019, Letnik:
112, Številka:
1
Journal Article
To determine whether the pathological response to preoperative chemotherapy for pancreatic ductal adenocarcinoma (PDAC) can be predicted using 2-18F-fluoro-2-deoxy-d-glucose positron-emission ...tomography (F-18 FDG-PET).
Twenty-eight patients with PDAC who underwent only neoadjuvant chemotherapy (NAC) before surgery were enrolled in the study. All patients had F-18 FDG-PET examinations before NAC. The resected specimen was pathologically evaluated according to the Classification of Pancreatic Carcinoma (7th edn). Patients were categorised into a non-response group and a response group based on the pathological findings. The non-response group (Grades 1a and 1b) showed ≤50% necrosis in the specimen, while the specimens of the response group (Grades 2–3) showed >50% necrosis. The maximum standardised uptake values (SUVmax) of the tumours on F-18 FDG-PET were measured. The mean values of SUVmax were compared between the two groups. The diagnostic performance of SUVmax in distinguishing the two groups was also evaluated using receiver operating characteristic analysis.
The mean SUVmax of the response group was higher than that of the non-response group (9.00 ± 1.78 versus 4.26 ± 2.35; p<0.001). The optimal cut-off value of SUVmax was 9.28 for distinguishing the two groups. The sensitivity, specificity, and accuracy for the prediction in the response group were 80%, 95.7%, and 92.9%, respectively.
SUVmax on F-18 FDG-PET may be useful as a biomarker to predict the pathological response to NAC in patients with PDAC.
•Pancreatic adenocarcinoma (PDAC) with high SUVmax appears to respond well to neoadjuvant chemotherapy (NAC).•SUVmax could be suitable biomarker for predicting response to NAC in PDAC.•Baseline PDAC SUVmax might help guide personalised treatment decisions in the future and warrants further study.
The antibacterial effect of surface modifications to titanium on
Porphyromonas gingivalis ATCC 33277 and
Actinobacillus actinomycetemcomitans ATCC 43718 was evaluated. Surface modifications were ...performed with dry processes including ion implantation (Ca
+, N
+, F
+), oxidation (anode oxidation, titania spraying), ion plating (TiN, alumina), and ion beam mixing (Ag, Sn, Zn, Pt) with Ar
+ on polished pure titanium plates. F
+-implanted specimens significantly inhibited the growth of both
P. gingivalis and
A. actinomycetemcomitans than the polished titanium. The other surface-modified specimens did not exhibit effective antibacterial activity against both bacteria. No release of the fluorine ion was detected from F-implanted specimens under dissolution testing. This result and the characterization of the F
+-implanted surfaces suggested that the possible antibacterial mechanism of the F
+-implanted specimen was caused by the formation of a metal fluoride complex on the surfaces. In addition, F
+-implanted surfaces did not inhibit the proliferation of fibroblast L929-cells. These findings indicate that surface modification by means of a dry process is useful in providing antibacterial activity of oral bacteria to titanium implants exposed to the oral cavity.
Synovial sarcoma accounts for almost 10% of all soft tissue sarcomas, and its prognosis is poor with 5-year survival rates at 36%. Thus, new treatments and therapeutic targets for synovial sarcoma ...are required. Tumor-initiating cells have been defined by the ability for self-renewal and multipotent differentiation, and they exhibit higher tumorigenic capacity, chemoresistance and radiation resistance, expecting to be a new therapeutic target. In synovial sarcoma, the presence of such stemness remains largely unclear; thus, we analyzed whether synovial sarcoma possessed tumor-initiating cells and explored specific markers, and we discovered that synovial sarcoma cell lines possessed heterogeneity by way of containing a sphere-forming subpopulation highly expressing NANOG, OCT4 and SOX2. By expression microarray analysis, CXCR4 was identified to be highly expressed in the sphere subpopulation and correlated with stem-cell-associated markers. Inhibition of CXCR4 suppressed the cell proliferation of synovial sarcoma cell lines in vitro. The tumor-initiating ability of CXCR4-positive cells was demonstrated by xenograft propagation assay. CXCR4-positive cells showed higher tumorigenicity than negative ones and possessed both self-renewal and multipotent differentiation ability. Immunohistochemical analysis of 39 specimens of synovial sarcoma patients revealed that CXCR4 strongly correlated with poor prognosis of synovial sarcoma. Thus, we conclude that CXCR4 is the marker of synovial sarcoma-initiating cells, a new biomarker for prognosis and a new potential therapeutic target.
Objectives: The lectin-like oxidized low density lipoprotein (ox-LDL) receptor 1 (LOX-1)/ox-LDL system, which contributes to the pathogenesis of atherosclerosis, may be involved in the development of ...osteoarthritis (OA). However, the mechanisms by which the LOX-1/ox-LDL system contributes to OA development in vivo are unclear. In this study, we investigated the direct involvement of LOX-1/ox-LDL in OA development by using LOX-1-knockout (LOX-1
-
/
-
) mice in a joint instability-induced model of OA.
Method: OA development was evaluated with histological scoring at 4 and 8 weeks after surgery to induce knee destabilization in LOX-1
+
/
+
and LOX-1
-
/
-
mice. Immunohistological analysis was used to evaluate the expression of LOX-1, ox-LDL, Runt-related transcription factor 2 (Runx2), and type X collagen (COL X) in articular chondrocytes and osteophyte-forming cells. In addition, double immunofluorescence staining was performed to determine the relationships between LOX-1 and Runx2 or COL X expression.
Results: In the model of knee destabilization, symptoms were significantly suppressed in LOX-1
-
/
-
mice. LOX-1, ox-LDL, Runx2, and COL X were overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1
+
/
+
mice and were significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1
-
/
-
mice compared with those in LOX-1
+
/
+
mice. Double immunostaining indicated that LOX-1 localization coincided with Runx2 and COL X expression.
Conclusions: These data indicate that the LOX-1/ox-LDL system plays a pivotal role in the pathogenesis of instability-induced OA through endochondral ossification. LOX-1-positive chondrocytes and osteophyte-forming cells may be possible targets to prevent disease progression in OA.
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