A search for highly electrically charged objects (HECOs) and magnetic monopoles is presented using 2.2
fb
-
1
of
p
-
p
collision data taken at a centre of mass energy (E
CM
) of 8 TeV by the MoEDAL ...detector during LHC’s Run-1. The data were collected using MoEDAL’s prototype Nuclear Track Detectord array and the Trapping Detector array. The results are interpreted in terms of Drell–Yan pair production of stable HECO and monopole pairs with three spin hypotheses (0, 1/2 and 1). The search provides constraints on the direct production of magnetic monopoles carrying one to four Dirac magnetic charges and with mass limits ranging from 590 GeV/c
2
to 1 TeV/c
2
. Additionally, mass limits are placed on HECOs with charge in the range 10
e
to 180
e
, where
e
is the charge of an electron, for masses between 30 GeV/c
2
and 1 TeV/c
2
.
Abstract Objective ERRs (estrogen-related receptors) regulate energy metabolism, the cell cycle and inflammatory processes in both normal and cancer cells. Chronic inflammation induced by lichen ...sclerosus (LS) or human papilloma virus (HPV) precedes vulvar squamous cell carcinoma (vulvar SCC). We investigated the expression of ERRα, ERRβ and ERRγ in normal vulvar skin, LS as well as LS-dependent and LS-independent/HPV-related vulvar SCC. Methods A total of 203 samples were analyzed for ERRα, ERRβ and ERRγ by using immunohistochemistry. These included 37 normal vulvar skin samples, 110 LS samples, 6 vulvar intraepithelial neoplasia (VIN) samples and 50 vulvar SCC samples. Results A substantial reduction in or disappearance of ERRα was detected in all vulvar SCC samples. A total of 79% of childhood-onset LS and 51% of adulthood-onset LS lesions showed decreases in ERRα staining. A gradual reduction in ERRα cytoplasmic staining was observed from healthy vulvar skin to precursor lesions and further to SCC. Nuclear ERRα staining was observed in 8/33 (24%) LS-dependent and 10/17 (59%) LS-independent SCC samples. Conclusions ERRα, a key regulator of cell energy metabolism, may play a role in the pathogenesis of both LS and vulvar SCC.
Purpose
The two main etiological factors for vulvar squamous cell carcinoma (vSCC) are the vulvar dermatosis lichen sclerosus (LS) and high-risk human papillomavirus (hrHPV). Serpin A1 ...(α1-antitrypsin) is a serine protease inhibitor, which plays a role in the tumorigenesis of various cancer types. The aim of the study was to evaluate the expressions of Serpin A1 in LS, premalignant vulvar lesions, and vSCC using immunohistochemistry (IHC) and serum analysis, and to compare Serpin A1 stainings to the tumor markers p53 and p16.
Methods
In total, 120 samples from 74 patients were studied with IHC for Serpin A1, p53 and p16: 18 normal vulvar skin, 53 LS, 9 premalignant vulvar lesions (dVIN/HSIL) and 40 vSCC samples. Serum concentrations of Serpin A1 were analyzed from 30 LS, 44 vSCC and 10 control patients. Expressions were compared to clinical data.
Results
Tumor cell-specific Serpin A1 overexpression was detected in 88% of vSCC samples, independent of the etiology. The intensity of Serpin A1 expression was significantly higher in vSCC than in healthy vulvar skin, LS, or premalignant vulvar lesions. Serpin A1 showed an association with p53 positivity. No difference in overall survival was found between Serpin A1-, p53-, or p16-positive vSCC patients. Serum concentrations of Serpin A1 were equal in the LS, vSCC, and control groups.
Conclusion
Tumor cell-specific Serpin A1 overexpression is a potential biomarker in vSCC.
We update our previous search for trapped magnetic monopoles in LHC Run 2 using nearly six times more integrated luminosity and including additional models for the interpretation of the data. The ...MoEDAL forward trapping detector, comprising 222 kg of aluminium samples, was exposed to 2.11 fb−1 of 13 TeV proton–proton collisions near the LHCb interaction point and analysed by searching for induced persistent currents after passage through a superconducting magnetometer. Magnetic charges equal to the Dirac charge or above are excluded in all samples. The results are interpreted in Drell–Yan production models for monopoles with spins 0, 1/2 and 1: in addition to standard point-like couplings, we also consider couplings with momentum-dependent form factors. The search provides the best current laboratory constraints for monopoles with magnetic charges ranging from two to five times the Dirac charge.
Precise knowledge of the beam optics at the LHC is crucial to fulfill the physics goals of the TOTEM experiment, where the kinematics of the scattered protons is reconstructed with near-beam ...telescopes-so-called Roman pots (RP). Before being detected, the protons' trajectories are influenced by the magnetic fields of the accelerator lattice. Thus precise understanding of the proton transport is of key importance for the experiment. A novel method of optics evaluation is proposed which exploits kinematical distributions of elastically scattered protons observed in the RPs. Theoretical predictions, as well as Monte Carlo studies, show that the residual uncertainty of the optics estimation method is smaller than .
The cross sections for single and double diffraction dissociation at low missing masses are calculated for the LHC energies on the basis of the dual (Regge) model under the assumption of a dominant ...contribution of the exchange of the Pomeron Regge pole. The model reproduces the rich resonance structure in the region of low missing masses
M
x
. Diffractively excited states lie on the nucleon trajectory
M
x
supplemented with the isolated Roper resonance. Detailed predictions for the squared momentum transfer and missing-mass dependence of the differential and integrated single and double diffraction dissociation in the kinematical range of present and future LHC measurements are given.
Ways to detect a light Higgs boson at the LHC De Roeck, A.; Khoze, V.A.; Martin, A.D. ...
The European physical journal. C, Particles and fields,
10/2002, Letnik:
25, Številka:
3
Journal Article
Recenzirano
Odprti dostop
We summarize the possible processes which may be used to search for a Higgs boson, of mass in the range 114-130 GeV, at the LHC. We discuss, in detail, two processes with rapidity gaps: exclusive ...Higgs production with tagged outgoing protons and production by Weak Boson Fusion, in each case taking \(H\to b \bar b\) as the signal. We make an extensive study of all possible \(b \bar b\) backgrounds, and discuss the relevant experimental issues. We emphasize the special features of these signals, and of their background processes, and show that they could play an important role in identifying a light Higgs boson at the LHC.
PDF
