Variations in structural, thermodynamic, and electrochemical properties due to partial replacement of Zr by Ti in stoichiometricTixZr1-x(VNiCrMnCoAl)2 AB2 alloys, have been studied. In particular, ...these properties are evaluated to determine the alloys' potential as a negative electrode material for high energy density nickel metal hydride batteries. Alloys having an x value of from 0.49 to 0.61 are dominated by a C14 Laves phase crystal structure. As Ti-content increases, lattice constants a and c decrease non linearly, the absolute value of hydride heat of formation decreases, the total gas-phase storage capacity decreases and the high rate dischargeability increases. However, the electrochemical capacity remains relatively constant.
BRCA1 has been implicated in the DNA damage pathway and regulation of genome stability, however, it does not contain intrinsic catalytic activity to repair the DNA lesions. Thus, a potential activity ...of BRCA1 is to assemble proteins that sense DNA damage and to transduce checkpoint signals to downstream. We have recently isolated a protein termed BAAT1, which binds to BRCA1, ATM, DNA-PKcs, and SMC1. Phosphorylation of ATM/DNA-PKcs is greatly reduced in BAAT1-knockdown cells, suggesting that sensing of DNA lesions mediated by BRCA1/BAAT1 is critical for activation of these kinases.
In Part 1 and Part 2 of this series of papers, the pressure–concentration–temperature (PCT) isotherms hysteresis was found to be closely related to the axial ratio
a/
c for both simple ternary and ...more complicated multi-element C14 Laves phase based alloys. Furthermore, the particle pulverization rate, which is the major determining factor in the duration of metal hydride electrode cycling, was found to correlate well with PCT hysteresis. In the current Part 3, we discuss an empirical equation which was developed to predict the PCT hysteresis of battery alloys through the study of the lattice constant ratios of a series of ZrCr
2-based ternary alloys. The empirical formula can then be used to estimate the pulverization rate of metal hydride electrode. To fit the empirical formula, an equivalent number of outer shell electrons for some non-transition metals was calculated from the axial ratio of ZrCr
1.8M
0.2 ternary alloys, where M is an element from the group of Al, Si, Ga, Ge, and Sn. Other factors, such as the amount of substitution, the difference in A and B element electronegativities, atomic size, and the choice of A element, were also investigated.
Summary
Electron beam therapy (EBT) is an established treatment for mycosis fungoides (MF), but evidence for the use of EBT in advanced cutaneous conditions is limited, and optimal scheduling of the ...regimen for such conditions remains unclear. We report the case of a 44‐year‐old woman diagnosed with MF with widespread cutaneous lesions, including multiple huge tumours in the craniofacial area. Low‐dose total skin (TS)EBT and subsequent localized skin (LS)EBT achieved striking improvements in eruptions. Oral etretinate was also administered during therapy. Our experience implies that combined TSEBT and LSEBT may be worth attempting when a patient presents with both widespread lesions and prominent tumours, even when the tumours are extremely large.
The effects of aluminum substitution to the structural, electrochemical, and gas phase hydrogen storage properties of C14-rich alloys are reported. Minor phases, including C15 and TiNi, were ...identified by X-ray diffraction analysis. Entropy and enthalpy were estimated from equilibrium pressure at a fixed hydrogen concentration due to the large slope factor in pressure–concentration–temperature isotherms. The stability of hydrides from these materials, determined from the pressure–concentration isotherm equilibrium pressure and maximum storage capacities has a better correlation with the change in entropy than that in enthalpy. Alloys having smaller unit cell volume, relatively low hydride heat of formation, and relatively higher degree of disorder exhibit lower plateau pressure, higher storage capacity, and smaller hydrogen diffusion coefficient. Comparing to the Co substitution in the same base alloy, Al substitution makes better contribution to both bulk hydrogen transport and surface reaction. Substituting 0.4% Al and 1.5% Co to AB2 alloy is found to be the best combination in terms of general nickel metal hydride battery performance.
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