The efficient (site-specific) management of soil nutrients is possible by understanding the spatial variability in distribution of phyto-available nutrients (here after called available nutrients) ...and identifying the soil management zones (MZs) of agricultural landscapes. There is need for delineating soil MZs of agricultural landscapes of the world for efficient management of soil nutrients in order to obtain sustainability in crop yield. The present study was, therefore, undertaken to understand the spatial distribution pattern of available micronutrients (zinc (Zn), boron (B), iron (Fe), manganese (Mn) and copper (Cu)), available sulphur (S), and soil properties (soil acidity (pH), electrical conductivity (EC) and organic carbon (SOC) content) in soils of intensively cultivated Indo-Gangetic Plain (IGP) of India and to delineate soil MZs for efficient management of soil nutrients. Totally, 55101 soil samples from 0-15 cm depth were obtained from 167 districts of IGP during 2014 to 2017 and were analysed for different soil parameters. Soil pH, EC and SOC content varied from 4.44 to 9.80, 0.02 to 2.13 dS m.sup.-1 and 0.10 to 1.99%, respectively. The concentration of available Zn, B, Fe, Mn, Cu and S varied from 0.01 to 3.27, 0.01 to 3.51, 0.19 to 55.7, 0.05 to 49.0, 0.01 to 5.29 and 1.01 to 108 mg kg.sup.-1, respectively. Geostatistical analysis resulted in varied distribution pattern of studied soil parameters with moderate to strong spatial dependence. The extent (% area) of nutrient deficiencies in IGP followed the order: S > Zn > B > Mn > Cu > Fe. Principal component analysis and fuzzy c-means clustering produced six distinctly different soil MZs of IGP for implementation of zone-specific soil nutrient management strategies for attaining sustainability in crop yield. The developed MZ maps could also be utilized for prioritization and rationalization of nutrients supply in IGP of India.
Understanding the spatial spreading patterns of plant-available sulphur (S) (AS) and plant-available micronutrients (available zinc (AZn), available iron (AFe), available copper (ACu), available ...manganese (AMn) and available boron (AB)) in soils, especially in coastal agricultural soils subjected to various natural and anthropogenic activities, is vital for sustainable crop production by adopting site-specific nutrient management (SSNM) strategies. We studied the spatial distribution patterns of AS, AZn, AFe, ACu, AMn, and AB in cultivated soils of coastal districts of India using geostatistical approaches. Altogether 39,097 soil samples from surface (0 to 15 cm depth) layers were gathered from farm lands of 68 coastal districts. The analysis of soil samples was carried out for soil pH, electrical conductivity (EC), soil organic carbon (SOC) and AS, AZn, AFe, ACu, AMn, and AB. Soil pH, EC and SOC varied from 3.70 to 9.90, 0.01 to 7.45 dS m.sup.-1 and 0.02 to 3.74%, respectively. The concentrations of AS, AZn, AFe, ACu, AMn, and AB varied widely in the study area with their corresponding mean values were 37.4±29.4, 1.50±1.53, 27.9±35.1, 2.14±1.74, 16.9±18.4 and 1.34±1.52 mg kg.sup.-1, respectively. The coefficient of variation values of analyzed soil parameters varied from 14.6 to 126%. The concentrations of AS, AZn, AFe, ACu, AMn, and AB were negatively and significantly correlated with soil pH and positively and significantly correlated with SOC. The geostatistical analysis indicated stable, Gaussian and exponential best-fit semivariogram models with moderate to strong spatial dependence for available nutrients. The generated spatial spreading maps revealed different distribution patterns for AS, AZn, AFe, ACu, AMn, and AB. There were variations in spatial spreading patterns of AS, AZn, AFe, ACu, AMn, and AB in east- and west-coastal area. About 62, 35, 12, 0.4, 23 and 45% of the study area had deficiency of AS, AZn, AFe, ACu, AMn, and AB, respectively. The spatial spreading maps will be highly useful for SSNM in the cultivated coastal soils of the country. This study could also be used as a base for assessing spatial spreading patterns of soil parameters in cultivated coastal areas of other parts of the world.
The paper presents the robust finite-time tracking of Stewart platform using super-twisting sliding mode observer based forward kinematics solution. The forward kinematics problem-finding the states ...from the leg length measurements-in Stewart platform gives nonunique solution for any given leg lengths, and due to this it poses difficulties in the control design. The super-twisting observer is designed from the available leg length measurements which is the output of the system to obtain the position and orientation of movable platform and their respective derivatives. The finite-time convergence of this observer and the stability of the closed loop system are presented in detail. It is shown that using this leg length measurements, the states of the observer converge to actual state in finite-time and hence, it provides a solution to the forward kinematics problem. Using these estimated states, a robust finite-time tracking control is designed for the Stewart platform by considering all the uncertainties and parameter variations. However, the proposed method for forward kinematics solution can also be incorporated with any other control strategies. Simulation results are given to demonstrate the performance of the proposed observer for the Stewart platform.
Aquaculture is emerging as one of the most viable and promising enterprises for keeping pace with the surging need for animal protein, providing nutritional and food security to humans, particularly ...those residing in regions where livestock is relatively scarce. With every step toward intensification of aquaculture practices, there is an increase in the stress level in the animal as well as the environment. Hence, disease outbreak is being increasingly recognized as one of the most important constraints to aquaculture production in many countries, including India. Conventionally, the disease control in aquaculture has relied on the use of chemical compounds and antibiotics. The development of non-antibiotic and environmentally friendly agents is one of the key factors for health management in aquaculture. Consequently, with the emerging need for environmentally friendly aquaculture, the use of alternatives to antibiotic growth promoters in fish nutrition is now widely accepted. In recent years, probiotics have taken center stage and are being used as an unconventional approach that has numerous beneficial effects in fish and shellfish culture: improved activity of gastrointestinal microbiota and enhanced immune status, disease resistance, survival, feed utilization and growth performance. As natural products, probiotics have much potential to increase the efficiency and sustainability of aquaculture production. Therefore, comprehensive research to fully characterize the intestinal microbiota of prominent fish species, mechanisms of action of probiotics and their effects on the intestinal ecosystem, immunity, fish health and performance is reasonable. This review highlights the classifications and applications of probiotics in aquaculture. The review also summarizes the advancement and research highlights of the probiotic status and mode of action, which are of great significance from an ecofriendly, sustainable, intensive aquaculture point of view.
We report a 16-year-old boy who presented with abdominal pain and severe hyperglycemia. His random blood glucose on admission was above 300 mg/dL, without ketosis. Urine examination revealed mild ...ketonuria. Renal function tests were normal. Antibodies to glutamate acid decarboxylase (anti-GAD) and islet tyrosine phosphatase 2 (anti-IA2) were negative. Findings on enhanced abdominal computed tomography scan were compatible with complete dorsal pancreatic agenesis. The body and tail of the pancreas were not visualized. Additionally, ectopic and malrotated left kidney was detected. Magnetic resonance cholangiopancreatography confirmed the absence of the dorsal pancreatic duct. The patient was treated with multiple subcutaneous insulin injections and attained good glycemic control. He is currently doing well on follow-up. The present case is a rare combination of complete agenesis of the dorsal pancreas with an ectopic, malrotated kidney. Clinical awareness of this rare association will help improve patient management.
One of the ways to mitigate the world energy crisis is to harvest clean and green energy from waste-heat, which is abundant, ubiquitous, and free. Energy harvesting of this waste-heat is one of the ...most encouraging methods to capture freely accessible electrical energy. Ferroelectric materials can be used to harvest energy for low power electronic devices, as they exhibit switchable polarization, excellent piezoelectric and pyroelectric properties. The most important characteristic of ferroelectric materials, in the context of energy harvesting, is their ability to generate electric power from a time-dependent temperature change. In this work, we grew highly c-axis oriented heterostructures of BaZr
Ti
O
(barium zirconium titanate, BZT)/Ba
Ca
TiO
(barium calcium titanate, BCT) on SrRuO
(strontium ruthenate, SRO) and deposited on SrTiO
(strontium titanate, STO) single crystalline substrate using pulsed laser deposition (PLD) technique. We investigated the structural, electrical, dielectric, and pyroelectric properties of the above-mentioned fabricated heterostructures. The wide range of θ-2θ X-ray diffraction (XRD) patterns only shows (00l) reflection peaks of heterostructures and the substrate which confirmed that the films are highly c-axis oriented. We are also capable to convert the low-grade waste-heat into electrical energy by measuring various temperature-dependent ferroelectric hysteresis loops of our nanostructure films via pyroelectric Ericsson cycles and the structures show an energy conversion density ~ 10,970 kJ/m
per cycle. These devices exhibit a large pyroelectric current density of ~ 25 mA/m
with 11.8 °C of temperature fluctuation and the corresponding pyroelectric coefficient of 3425 μC/m
K. Our research findings suggest that these lead-free relaxor-ferroelectric heterostructures might be the potential candidates to harvest electrical energy from waste low-grade thermal energy.
The dominant mode of interannual variability in summertime high‐frequency tropospheric temperature fluctuations over Southern Africa is found to be associated with tropical Pacific sea surface ...temperature variability, in such a manner that El Niño is typically accompanied by enhanced high‐frequency variability. This relationship is established via El Niño's teleconnection that contributes to shifting the midlatitude jetstream and associated baroclinic zone equatorward, into the vicinity of Southern Africa, which enhances the baroclinic conversion of energy from the seasonal‐mean flow to high‐frequency eddies. The enhanced temperature variance, combined with the overall warmer summertime‐mean temperatures induced by El Niño, results in more frequent warm extremes over Southern Africa.
Plain Language Summary
When warmer‐than‐normal sea surface temperatures associated with El Niño are observed over the Eastern/Central Tropical Pacific Ocean, day‐to‐day surface temperature variability tends to be enhanced over Southern Africa in summer. This relationship is due to the remote impact of El Niño on the atmospheric circulation in the vicinity of Southern Africa, which favors transfers of energy from the summertime‐mean atmospheric circulation into weather systems responsible for temperature fluctuations on daily timescales. This transfer of energy is directly related to southward and northward displacements of warm and cold air masses, respectively, thereby leading to amplified temperature variations near the surface.
Key Points
El Niño accompanies enhanced summertime high‐frequency temperature variability over South Africa
Due to enhanced baroclinic energy conversion concomitant with a northward shift of the jetstream and baroclinic zone toward South Africa
The enhanced high‐frequency variance coincides with warmer seasonal‐mean temperatures, leading to more frequent warm extremes
Constitutive activation of signal transducer and activator of transcription 3 (STAT3) has been linked with proliferation, survival, invasion and angiogenesis of a variety of human cancer cells, ...including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 activation have potential for both prevention and treatment of HCC. Here we report, garcinol, a polyisoprenylated benzophenone, could suppress STAT3 activation in HCC cell lines and in xenografted tumor of HCC in nude mice model.
Different HCC cell lines have been treated with garcinol and the inhibition of STAT3 activation, dimerization and acetylation have been checked by immunoblotting, immuno-fluorescence, and DNA binding assays. Xenografted tumor model has been generated in nude mice using HCC cell line and effect of garcinol in the inhibition of tumor growth has been investigated.
Garcinol could inhibit both constitutive and interleukin (IL-6) inducible STAT3 activation in HCC cells. Computational modeling showed that garcinol could bind to the SH2 domain of STAT3 and suppress its dimerization in vitro. Being an acetyltransferase inhibitor, garcinol also inhibits STAT3 acetylation and thus impairs its DNA binding ability. The inhibition of STAT3 activation by garcinol led to the suppression of expression of various genes involved in proliferation, survival, and angiogenesis. It also suppressed proliferation and induced substantial apoptosis in HCC cells. Remarkably, garcinol inhibited the growth of human HCC xenograft tumors in athymic nu/nu mice, through the inhibition of STAT3 activation.
Overall, our results suggest that garcinol exerts its anti-proliferative and pro-apoptotic effects through suppression of STAT3 signaling in HCC both in vitro and in vivo.
The variability in the East African short rains is investigated using 41-yr data from the observation and 200-yr data from a coupled general circulation model known as the Scale Interaction ...Experiment-Frontier Research Center for Global Change, version 1 (SINTEX-F1). The model-simulated data provide a scope to understand the climate variability in the region with a better statistical confidence. Most of the variability in the model short rains is linked to the basinwide large-scale coupled mode, that is, the Indian Ocean dipole (IOD) in the tropical Indian Ocean. The analysis of observed data and model results reveals that the influence of the IOD on short rains is overwhelming as compared to that of the El Niño–Southern Oscillation (ENSO); the correlation between ENSO and short rains is insignificant when the IOD influence is excluded. The IOD–short rains relationship does not change significantly in a model experiment in which the ENSO influence is removed by decoupling the ocean and atmosphere in the tropical Pacific. The partial correlation analysis of the model data demonstrates that a secondary influence comes from a regional mode located near the African coast.
Inconsistent with the observational findings, the model results show a steady evolution of IOD prior to extreme events of short rains. Dynamically consistent evolution of correlations is found in anomalies of the surface winds, currents, sea surface height, and sea surface temperature. Anomalous changes of the Walker circulation provide a necessary driving mechanism for anomalous moisture transport and convection over the coastal East Africa. The model results nicely augment the observational findings and provide us with a physical basis to consider IOD as a predictor for variations of the short rains. This is demonstrated in detail using the statistical analysis method. The prediction skill of the dipole mode SST index in July and August is 92% for the observation, which scales slightly higher for the model index (96%) in August. As observed in data, the model results show decadal weakening in the relationship between IOD and short rains owing to weakening in the IOD activity.
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