MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an ...integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA (sRNA) libraries, with matching Cap Analysis Gene Expression (CAGE) data, from 396 human and 47 mouse RNA samples. Promoters were identified for 1,357 human and 804 mouse miRNAs and showed strong sequence conservation between species. We also found that primary and mature miRNA expression levels were correlated, allowing us to use the primary miRNA measurements as a proxy for mature miRNA levels in a total of 1,829 human and 1,029 mouse CAGE libraries. We thus provide a broad atlas of miRNA expression and promoters in primary mammalian cells, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions.
Predicted increases in suicide were not generally observed in the early months of the COVID-19 pandemic. However, the picture may be changing and patterns might vary across demographic groups. We ...aimed to provide a timely, granular picture of the pandemic's impact on suicides globally.
We identified suicide data from official public-sector sources for countries/areas-within-countries, searching websites and academic literature and contacting data custodians and authors as necessary. We sent our first data request on 22nd June 2021 and stopped collecting data on 31st October 2021. We used interrupted time series (ITS) analyses to model the association between the pandemic's emergence and total suicides and suicides by sex-, age- and sex-by-age in each country/area-within-country. We compared the observed and expected numbers of suicides in the pandemic's first nine and first 10-15 months and used meta-regression to explore sources of variation.
We sourced data from 33 countries (24 high-income, six upper-middle-income, three lower-middle-income; 25 with whole-country data, 12 with data for area(s)-within-the-country, four with both). There was no evidence of greater-than-expected numbers of suicides in the majority of countries/areas-within-countries in any analysis; more commonly, there was evidence of lower-than-expected numbers. Certain sex, age and sex-by-age groups stood out as potentially concerning, but these were not consistent across countries/areas-within-countries. In the meta-regression, different patterns were not explained by countries’ COVID-19 mortality rate, stringency of public health response, economic support level, or presence of a national suicide prevention strategy. Nor were they explained by countries’ income level, although the meta-regression only included data from high-income and upper-middle-income countries, and there were suggestions from the ITS analyses that lower-middle-income countries fared less well.
Although there are some countries/areas-within-countries where overall suicide numbers and numbers for certain sex- and age-based groups are greater-than-expected, these countries/areas-within-countries are in the minority. Any upward movement in suicide numbers in any place or group is concerning, and we need to remain alert to and respond to changes as the pandemic and its mental health and economic consequences continue.
None.
Extensive experimental data from high-energy nucleus-nucleus collisions were recorded using the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). The comprehensive set of measurements ...from the first three years of RHIC operation includes charged particle multiplicities, transverse energy, yield ratios and spectra of identified hadrons in a wide range of transverse momenta (
p
T
), elliptic flow, two-particle correlations, nonstatistical fluctuations, and suppression of particle production at high
p
T
. The results are examined with an emphasis on implications for the formation of a new state of dense matter. We find that the state of matter created at RHIC cannot be described in terms of ordinary color neutral hadrons.
We present observations of the unusually bright and long g-ray burst GRB 050820A, one of the best sampled broadband data sets in the Swift era. The g-ray light curve is marked by a soft precursor ...pulse some 200 s before the main event; the lack of any intervening emission suggests that it is due to a physical mechanism distinct from the GRB itself. The large time lag between the precursor and the main emission enabled simultaneous observations in the g-ray, X-ray, and optical bandpasses, something only achieved for a handful of events to date. While the contemporaneous X-rays are the low-energy tail of the prompt emission, the optical does not directly track the g-ray flux. Instead, the early-time optical data appear consistent with the forward shock synchrotron peak passing through the optical and are therefore likely the beginning of the afterglow. On hour timescales after the burst, the X-ray and optical light curves are inconsistent with an adiabatic expansion of the shock into the surrounding region, but rather indicate that there is a period of energy injection. Observations at late times allow us to constrain the collimation angle of the relativistic outflow to 6:8 f 9:3. Our estimates of both the kinetic energy of the afterglow (E sub(KE) = 5.2 super(+7.9-4.1) x 10 super(51) ergs) and the prompt g-ray energy release (E sub(g) = 7.5 super(+6.7-2.4) x 10 super(51) ergs) make GRB 050820A one of the most energetic events for which such values could be determined.
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