The contribution of the collateral network to myocardial oxygenation under normal circumstances is not clear. However, it is possible that in diseased myocardium this network may be activated and ...contributes significantly to cardiac blood supply. The purpose of this study was to examine the coronary sinus flow after acute, synchronous, complete occlusion of all epicardial coronary arteries and to investigate methods to increase the flow in the setting of ischaemia.
In 8 pigs, the coronary sinus flow was measured after complete ligation of all coronary arteries. In two of the 8 experiments adrenaline and dobutamine were infused into the left ventricular cavity, while clamping of the ascending aorta was performed in another three animals in an effort to increase left ventricular systolic pressure.
The mean coronary sinus flow decreased from 36.06 +/- 11.01 ml/min to 5.61 +/- 6.96 ml/min (p < 0.001) after ligation of the coronary arteries. A 67% mean reduction of coronary sinus flow at the first minute after ligation was observed and a progressive decrease of coronary sinus outflow to almost zero within 60 minutes was seen in some experiments. Neither infusion of adrenaline and dobutamine nor ascending aorta clamping increased the coronary sinus flow.
The preservation of coronary sinus flow after the complete occlusion of all coronary arteries indicates that retrograde flow through the collateral network from cardiac chambers may exist. Methods that increase the blood flow through the collateral network may contribute to the improvement of myocardial perfusion in severe coronary insufficiency.
Inclusive jet production is studied in neutral current deep-inelastic positron–proton scattering at large four momentum transfer squared
Q
2
>
150
GeV
2
with the H1 detector at HERA. Single and ...double differential inclusive jet cross sections are measured as a function of
Q
2
and of the transverse energy
E
T
of the jets in the Breit frame. The measurements are found to be well described by calculations at next-to-leading order in perturbative QCD. The running of the strong coupling is demonstrated and the value of
α
s
(
M
Z
)
is determined. The ratio of the inclusive jet cross section to the inclusive neutral current cross section is also measured and used to extract a precise value for
α
s
(
M
Z
)
=
0.1193
±
0.0014
(
exp.
)
−0.0030
+0.0047
(
th.
)
±
0.0016
(
pdf
)
.
Non-Hodgkin's lymphomas (NHL) were often erroneously diagnosed as other malignancies and treated accordingly. In this study cisplatin combined with vincristine, cyclophosphamide, and Adriamycin was ...used incidentally as a front-line treatment in seven children with NHL, because the initial histologic diagnosis was that of a sarcoma. After reevaluation three patients had Ki-1 anaplastic large cell lymphoma of T-cell origin, two abdominal B-cell diffuse high-grade NHL, one mediastinal diffuse large B-cell lymphoma, and one B-cell lymphoma in the stomach. They received at least two courses of cisplatin combined regimen and continued with other protocols for NHL. All patients showed an extremely good response from the first course of therapy and the masses vanished completely. They were followed up for a mean time of 29.5 months and are all in complete remission. The data indicate that cisplatin is active against NHL and might be a promising alternative front-line therapy.
PDF
