ABSTRACT We present the Spitzer Extragalactic Representative Volume Survey (SERVS), an 18 deg2 medium-deep survey at 3.6 and 4.5 μm with the postcryogenic Spitzer Space Telescope to ≈2 μJy ...(AB = 23.1) depth of five highly observed astronomical fields (ELAIS-N1, ELAIS-S1, Lockman Hole, Chandra Deep Field South, and XMM-LSS). SERVS is designed to enable the study of galaxy evolution as a function of environment from z ∼ 5 to the present day and is the first extragalactic survey that is both large enough and deep enough to put rare objects such as luminous quasars and galaxy clusters at z ≳ 1 into their cosmological context. SERVS is designed to overlap with several key surveys at optical, near- through far-infrared, submillimeter, and radio wavelengths to provide an unprecedented view of the formation and evolution of massive galaxies. In this article, we discuss the SERVS survey design, the data processing flow from image reduction and mosaicking to catalogs, and coverage of ancillary data from other surveys in the SERVS fields. We also highlight a variety of early science results from the survey.
Optimal first-step antihypertensive drug therapy in type 2 diabetes mellitus (DM) or impaired fasting glucose levels (IFG) is uncertain. We wished to determine whether treatment with a calcium ...channel blocker or an angiotensin-converting enzyme inhibitor decreases clinical complications compared with treatment with a thiazide-type diuretic in DM, IFG, and normoglycemia (NG).
Active-controlled trial in 31 512 adults, 55 years or older, with hypertension and at least 1 other risk factor for coronary heart disease, stratified into DM (n = 13 101), IFG (n = 1399), and NG (n = 17 012) groups on the basis of national guidelines. Participants were randomly assigned to double-blind first-step treatment with chlorthalidone, 12.5 to 25 mg/d, amlodipine besylate, 2.5 to 10 mg/d, or lisinopril, 10 to 40 mg/d. We conducted an intention-to-treat analysis of fatal coronary heart disease or nonfatal myocardial infarction (primary outcome), total mortality, and other clinical complications.
There was no significant difference in relative risk (RR) for the primary outcome in DM or NG participants assigned to amlodipine or lisinopril vs chlorthalidone or in IFG participants assigned to lisinopril vs chlorthalidone. A significantly higher RR (95% confidence interval) was noted for the primary outcome in IFG participants assigned to amlodipine vs chlorthalidone (1.73 1.10-2.72). Stroke was more common in NG participants assigned to lisinopril vs chlorthalidone (1.31 1.10-1.57). Heart failure was more common in DM and NG participants assigned to amlodipine (1.39 1.22-1.59 and 1.30 1.12-1.51, respectively) or lisinopril (1.15 1.00-1.32 and 1.19 1.02-1.39, respectively) vs chlorthalidone.
Our results provide no evidence of superiority for treatment with calcium channel blockers or angiotensin-converting enzyme inhibitors compared with a thiazide-type diuretic during first-step antihypertensive therapy in DM, IFG, or NG.
Blood-culture broths showing macroscopic or radiometric evidence of growth of gram-negative bacilli were examined by a rapid automated bacterial identification system. A differential centrifugation ...technique was developed to prepare suitable inocula. The identification results obtained were confirmed by the API 20E method, with single colonies of the strains isolated 24 h later. Of 90 organisms tested, seven did not give the same identification by the two systems. With the rapid automated technique a presumptive identification of gram-negative bacilli can be made 24 h earlier than by more conventional methods.
We present the Spitzer Extragalactic Representative Volume Survey (SERVS), an 18 square degrees medium-deep survey at 3.6 and 4.5 microns with the post-cryogenic Spitzer Space Telescope to ~2 microJy ...(AB=23.1) depth of five highly observed astronomical fields (ELAIS-N1, ELAIS-S1, Lockman Hole, Chandra Deep Field South and XMM-LSS). SERVS is designed to enable the study of galaxy evolution as a function of environment from z~5 to the present day, and is the first extragalactic survey both large enough and deep enough to put rare objects such as luminous quasars and galaxy clusters at z>1 into their cosmological context. SERVS is designed to overlap with several key surveys at optical, near- through far-infrared, submillimeter and radio wavelengths to provide an unprecedented view of the formation and evolution of massive galaxies. In this paper, we discuss the SERVS survey design, the data processing flow from image reduction and mosaicing to catalogs, as well as coverage of ancillary data from other surveys in the SERVS fields. We also highlight a variety of early science results from the survey.
Several prospective studies have documented the effectiveness of oral cyclosporine in the treatment of psoriasis. Despite this, the use of cyclosporine has been limited because of concern about the ...possibility of drug-induced renal dysfunction. We review the effects of cyclosporine on renal function.
Follicular helper T (Tfh) cells provide selection signals to germinal center B cells, which is essential for long-lived antibody responses. High CXCR5 and low CCR7 expression facilitates their homing ...to B cell follicles and distinguishes them from T helper 1 (Th1), Th2, and Th17 cells. Here, we showed that Bcl-6 directs Tfh cell differentiation: Bcl-6-deficient T cells failed to develop into Tfh cells and could not sustain germinal center responses, whereas forced expression of Bcl-6 in CD4
+ T cells promoted expression of the hallmark Tfh cell molecules CXCR5, CXCR4, and PD-1. Bcl-6 bound to the promoters of the Th1 and Th17 cell transcriptional regulators T-bet and RORγt and repressed IFN-γ and IL-17 production. Bcl-6 also repressed expression of many microRNAs (miRNAs) predicted to control the Tfh cell signature, including miR-17-92, which repressed CXCR5 expression. Thus, Bcl-6 positively directs Tfh cell differentiation, through combined repression of miRNAs and transcription factors.
Motion pictures and the skin Parish, L.C.; Parish, S.G.
Journal of the European Academy of Dermatology and Venereology,
March 2018, 2018-Mar, 2018-03-00, 20180301, Letnik:
32, Številka:
3
Journal Article
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