ABSTRACT
Eclipse timing variations (ETVs) have been a successful tool for detecting circumbinary companions to eclipsing binaries (EBs). While TESS and Kepler have been prolific for ETV searches, ...they sometimes can be limited by time and sky coverage, a limitation that can be addressed by specialized ground-based ETV surveys. We present the initial results from the Solaris photometric survey, which uses four 0.5-m robotic telescopes in the Southern hemisphere to look for circumbinary companions. We present the method of light-curve extraction, detrending, and EB modelling using observations from the Solaris network. Using these light curves, we extract precise eclipse timings for seven EBs and look for companions using a Lomb–Scargle periodogram search. We find two possible periodic signals for the target GSC 08814–01026. With the system having strong activity, we check for the feasibility of orbital solutions at these two periods. We find that the 245 ± 1 d period is due to an M dwarf-mass companion. This makes GSC 08814–01026 a candidate compact hierarchical triple system. The other periodic signal at 146 ± 1 d is an artefact of stellar activity.
ABSTRACT
Compact hierarchical triples (CHTs) are systems with the tertiary star orbiting the inner binary in an orbit shorter than 1000 d. CHT with an eclipsing binary as its inner binary can help us ...extract a multitude of information about all three stars in the system. In this study, we use independent observational techniques to estimate the orbital, stellar, and atmospheric parameters of two triple-lined CHT: BD+44 2258 and KIC 06525196. We find that the masses of stars in BD+44 2258 are $1.011\pm 0.029$, $0.941\pm 0.033$, and $0.907\pm 0.065 \, {\rm M}_{\odot }$ while in KIC 06525196 the estimated masses are $1.0351\pm 0.0055$, $0.9712\pm 0.0039 $, and $0.777\pm 0.012 \, {\rm M}_{\odot }$. Using spectral disentangling, we obtained individual spectra of all the stars and combined it with light-curve modelling to obtain radii, metallicities, and temperatures. Using stellar evolution models from mesa, we constrain the log(age) of BD+44 2258 to be 9.89 and 9.49 for KIC 06525196. Two stars in BD+44 2258 are found to be sub-giants while all three stars in KIC 06525196 are main-sequence stars. We constrain the mutual inclinations to certain angles for BD+44 2258 and KIC 06525196 using numerical integration. Integrating with tidal interaction schemes and stellar evolution models, we find that KIC 06525196 is a stable system. But the inner binary of BD+44 2258 merges within 550 Myr. The time of this merger is affected by the orientation of the tertiary, even rushing the collapse by ∼100 Myr when the mutual inclination is close to 90○.
Diabetes mellitus is the most widely recognized endocrine disorder which is influencing a bigger populace on the planet. There are various causes of diabetes, such as physical inactivity, obesity, ...family history, race, and age. Diabetes mellitus is associated with some life-threatening complications, such as neuropathy, nephropathy, various eye diseases or retinopathy, and cardiovascular disorders. Many synthetic antihyperglycemic agents are available in the market for the treatment of diabetes and its complications. But, due to some serious side effects of these synthetic agents, people are opting for herbal remedies and, therefore, they are now becoming popular. Herbal remedies have lesser side effects and higher affordability and therefore can be preferably used over synthetic agents for a long-term disorder like diabetes mellitus. In the present study, scientific research and review studies on the topic were collected from Science Direct, Scopus, PubMed, Google Scholar, and other relevant sources. The references of all the articles were screened manually for any additional information on popular polyherbal formulations in traditional Ayurvedic, Chinese, and Unani medicinal systems. It is found that these polyherbal formulations are studied for anti-diabetic potential. Furthermore, some are also investigated for mechanism of action of anti-diabetic effects. This review highlights various Ayurvedic, Chinese, and Unani polyherbal formulations commonly utilized in the management of diabetes mellitus along with their pre-clinical and clinical investigations, which will enhance the existing knowledge of the researchers.
ABSTRACT
We present results of the analysis of light and radial velocity (RV) curves of eight detached eclipsing binaries observed by the All-Sky Automated Survey, which we have followed up with ...high-resolution spectroscopy, and were later observed by the Keplersatellite as part of the K2mission. The RV measurements came from spectra obtained with OAO-188/HIDES, MPG-2.2 m/FEROS, SMARTS 1.5 m/CHIRON, Euler/CORALIE, ESO-3.6 m/HARPS, and OHP-1.93/ELODIE instruments. The K2 time-series photometry was analysed with the jktebop code, with out-of-eclipse modulations of different origin taken into account. Individual component spectra were retrieved with the fd3 code, and analysed with the code ispec in order to determine effective temperatures and metallicities. Absolute values of masses, radii, and other stellar parameters are calculated, as well as ages, found through isochrone fitting. For five systems, such analysis has been done for the first time. The presented sample consists of a variety of stars, from low-mass dwarfs, through G- and F-type main sequence objects, to evolved active sub-giants, one of which is found to be crossing the Hertzsprung gap. One target may contain a γ Dor-type pulsator, two more are parts of higher-order multiples, and spectra of their tertiaries were also retrieved and used to constrain the properties of these systems.
ABSTRACT
The pulsating eclipsing binaries are remarkable systems that provide an opportunity to probe the stellar interior and to determine the fundamental stellar parameters precisely. Especially ...the detached eclipsing binary systems with (a) pulsating component(s) are significant objects to understand the nature of the oscillations since the binary effects in these systems are negligible. Recent studies based on space data have shown that the pulsation mechanisms of some oscillating stars are not completely understood. Hence, comprehensive studies of a number of pulsating stars within detached eclipsing binaries are important. In this study, we present a detailed analysis of the pulsating detached eclipsing binary system AI Hya which was studied by two independent groups with different methods. We carried out a spectroscopic survey to estimate the orbital parameters via radial velocity measurements and the atmospheric parameters of each binary component using the composite and/or disentangled spectra. We found that the more luminous component of the system is a massive, cool and chemically normal star while the hotter binary component is a slightly metal-rich object. The fundamental parameters of AI Hya were determined by the analysis of binary variations and subsequently used in the evolutionary modelling. Consequently, we obtained the age of the system as 850 ± 20 Myr and found that both binary components are situated in the δ Scuti instability strip. The frequency analysis revealed pulsation frequencies between 5.5 and 13.0 d−1 and we tried to estimate which binary component is the pulsating one. However, it turned out that those frequencies could originate from both binary components.
Breast cancer shows high mortality, especially in women worldwide. This report discusses a case of female patient with a history of Invasive Ductal Carcinoma (IDC) Rt Breast, ER, PR negative, Grade 3 ...(Gr3) Stage 3 (St3) seen in our OPD treated with supporting herbo-mineral-metallic combination of Ayurveda medicines. Generally, breast cancers of such subtype and that too in Lower Outer Quadrant (LOQ) are always of a concern and can be more troublesome to the patient. When the patient came for the first time, her chief complaint was palpable lump in her right breast for previous three months. We advised her to undergo relevant investigations and, it was found to be malignant. She underwent surgery, Modified Radical Mastectomy,(MRM), followed by chemotherapy. During chemotherapy, which was Adriamycin + Cyclophosphamide (AC) protocol 4 cycles, followed by Docetaxel 4 cycles, every 21 days. After 2 cycles, she started complaints of pain in both calf regions, numbness in fingers of hand and foot, severe generalized skin rash with itching, hyperacidity and constipation. She visited our clinic again for the same, and Ayurveda treatment was started to her at this point. So, at the time of commencement of treatment, the diagnosis was "IDC Rt Breast, LOQ, Gr3 St3, ER, PR negative HER2Neu positive, post op, on chemo".
After appropriate analysis based on Ayurvedic and modern parameters, she was diagnosed to have vitiation of Rakta and Pitta (Dushti avastha), due to cyto-toxic nature of (Visha exposure) chemotherapy and medication was planned accordingly, along with chemotherapy protocol. The Ayurveda treatment showed significant relief in the chemotoxicity symptoms, within one month and she could tolerate further chemotherapy cycles very conveniently.
On completion of chemotherapy, she was diagnosed to have need of good immunity (Vyadhi-Kshamatva). Based on this diagnosis, Ayurveda treatment protocol was changed and this new regimen continued for almost 6 years afterwards. Laboratory and imaging investigations performed periodically showed marked improvement, and even currently not showing any abnormality. Till date, there is no recurrence and patient is living completely normally for last 11 years.
As all the symptoms and investigations showed near complete improvement; it may be concluded that probably add on Ayurveda treatment (Integrative approach) proved effective in this patient of IDC. We have observed 11 years of disease-free survival and excellent quality of life in this patient and still ongoing.
Over two billion people around the world suffer from anemia. Majority of populations are using dietary supplements and herbal medicines for the management of the anemic conditions. Many polyherbal ...formulations such as RaktavardhakKadha (RK), are available in the Indian market as a nutritional supplement and herbal-based medicine for anemia.
The present study is aimed at investigating antianemic potential of polyherbal formulation, RK, against phenylhydrazine-induced anemia in rats.
RK was subjected to preliminary phytochemical analysis and iron estimation. Anemia was induced by phenylhydrazine administration (40 mg/kg, i.p.) for 2 consecutive days. Antianemic activity of RK was investigated at the dose of 1.8 ml/kg, twice daily for 12 days by estimating blood parameters and pathological changes in liver, heart, spleen and bone marrow.
RK was found to contain saponins, steroids, flavonoids, tannins and phenolic compounds. Iron content was found to be 5 mg/100 ml in RK. Anemia induction by phenylhydrazine injections to rats caused significant decrease in red blood cells (RBCs), hemoglobin and hematocrit. These decreased levels of RBCs, hemoglobin and hematocrit in blood was significantly improved by the treatment with RK. Furthermore, RK restored pathological changes in liver, heart, spleen and bone marrow tissues near to normal.
This study suggests antianemic activity of RK, which can be attributed to its iron content and ability to prevent hemolysis.
Malignant spindle cell melanoma is a rare cancer with a questionable prognosis because of limited published case reports. This article discusses a male patient with a history of Spindle cell melanoma ...tumor, Rt heel, Grade 3 (Gr 3) Stage 2 (St 2) seen in our OPD treated with supporting herbo-mineral combination of Ayurvedic medicine. Such types of cancers are of concern and can be more troublesome to the patient. The initial chief complaint of the patient was a palpable corn-like growth in the right heel, which was surgically removed at that time. When it recurred after one year, it was investigated thoroughly and it was found malignant, and then operated again.
The patient came to us after his second operation. After appropriate analysis based on Ayurvedic and modern parameters, the patient was treated with Ayurved treatment. As there was no other treatment suggested by oncologists, he was on supportive Ayurvedic treatment only. Ayurvedic treatment continued for 2 years afterwards. The treatment module showed complete relief in the symptoms (100%), by the end of treatment. Follow-up PET scans showed further improvement and a complete reversal of residual disease was observed. The last PET scan did not show any evidence of abnormality. To date, there has been no recurrence and the patient has been living completely normally for the last almost 5 years (karnofsky score 90/100). It can be concluded that the addition of Ayurvedic treatment might have helped this patient of malignant spindle cell melanoma for regression of residual disease, prevention of metastasis to date, and a good quality of life. We have observed 5+ years of disease-free survival and near-normal quality of life for this patient, and still ongoing.
This study investigated the protective effect of the hydro-alcoholic extract of roots of
Rubia cordifolia Linn. (HARC) against ethylene glycol induced urolithiasis and its possible underlying ...mechanisms using male Wistar albino rats. Ethylene glycol feeding resulted in hyperoxaluria, hypocalciuria as well as increased renal excretion of phosphate. Supplementation with HARC significantly prevented change in urinary calcium, oxalate and phosphate excretion dose-dependently. The increased calcium and oxalate levels and number of calcium oxalate crystals deposits in the kidney tissue of calculogenic rats were significantly reverted by HARC treatment. The HARC supplementation also prevents the impairment of renal functions.
Indicate that the HARC can protect against ethylene glycol induced urolithiasis as it reduced and prevented the growth of urinary stones. Therefore, HARC is helpful to prevent the recurrence of the disease as it showed its effect on early stages of stone development. The mechanism underlying this effect is mediated possibly through an antioxidant, nephroprotection and its effect on the urinary concentration of stone-forming constituents and risk factors.
The methanolic whole plant extract of Biophytum sensitivum (感应草gănyìng căo) has been found to possess antiurolithiatic effect. The present study was undertaken to evaluate the antiurolithiatic effect ...of some fractions of methanolic whole plant extract of B. sensitivum (MBS) in rats as a step toward activity-directed isolation of antiurolithiatic component. The MBS was successively extracted with dichloromethane, ethyl acetate, ethanol and water to obtain fractions. Sodium oxalate (70 mg/kg, i.p.) was administered to rats for seven days to develop calcium oxalate urolithiasis. These rats were treated with two doses (20 and 40 mg/kg, p.o.) of the fractions, 1 h before sodium oxalate injections. Antiurolithiatic activity was assessed by estimating biochemical changes in urine, serum and kidney homogenate along with histological changes in kidney tissue. Sodium oxalate administration caused biochemical alterations in urine which was found to be prevented significantly by the ethyl acetate fraction. Supplementation with ethyl acetate fraction prevented the elevation of serum creatinine, uric acid and blood urea nitrogen levels. The elevated calcium, oxalate and phosphate levels in the kidney tissue homogenate of lithiatic rats were significantly reduced by the treatment with ethyl acetate fraction. The ethyl acetate fraction also caused significant decrease in lipid peroxidation activity, accumulation of calcium oxalate deposits and histological changes in the kidney tissue. The results showed that the antiurolithiatic component of the methanolic whole plant extract of the plant is contained in the ethyl acetate fraction. The effect is attributed to its diuretic, antioxidant, nephroprotective properties and effect on lowering the concentration of urinary stone-forming constituents.
PDF
