Epidermal naevi are hamartomas that are characterized by hyperplasia of the epidermis and adnexal structures and may be associated with serious disfiguration. Management of epidermal naevi is ...challenging. We present here our experience with cryosurgery in the treatment of verrucous epidermal naevi. The aim of this study was to determine the efficacy and safety of cryosurgery for the treatment of epidermal naevi. Nine patients with verrucous epidermal naevi and two with extensive unilateral epidermal naevus were treated with cryosurgery. Two cycles of open spray technique were used, 10-15 sec each, depending on the size and extent of the naevus. Ten patients had their naevi treated successfully in 2-5 sessions with two cycles of therapy, and the cosmetic result was excellent with no scarring. One patient showed a relapse within 8 months after the treatment. One patient with phototype IV developed hypochromic scarring, but repigmentation occurred after 6 months. Postoperative healing time was 10-20 days. Cryosurgery is an extremely effective therapeutic modality for the treatment of epidermal naevi. The low cost, the simplicity of the technique and the good cosmetic result makes cryosurgery an excellent therapeutic modality for the treatment of epidermal naevus.
The NA49 large acceptance hadron detector Afanasiev, S.; Alber, T.; Appelshäuser, H. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
07/1999, Letnik:
430, Številka:
2
Journal Article
Recenzirano
Odprti dostop
The NA49 detector is a wide acceptance spectrometer for the study of hadron production in p+p, p+A, and A+A collisions at the CERN SPS. The main components are 4 large-volume TPCs for tracking and ...particle identification via d
E/d
x. TOF scintillator arrays complement particle identification. Calorimeters for transverse energy determination and triggering, a detector for centrality selection in p+A collisions, and beam definition detectors complete the set-up. A description of all detector components is given with emphasis on new technical realizations. Performance and operational experience are discussed in particular with respect to the high track density environment of central Pb+Pb collisions.
Pediatric parafalcine empyemas Niklewski, Franziska; Petridis, Athanasios K; Al Hourani, Jasmin ...
Journal of surgical case reports,
2013-Aug-29, Letnik:
2013, Številka:
8
Journal Article
Recenzirano
Odprti dostop
Subdural intracranial empyemas and brain abscesses are a rare complication of bacterial sinusitis. Pediatric parafalcine abscesses are a rare entity with different treatment compared with other brain ...abscesses. We present two pediatric cases with falcine abscess as a sinusitis complication and introduce our department's treatment management. In addition a review of literature is performed. Surgical cases of our department and their management are compared with the current literature. In our cases, both of the children showed a recurrent empyema after the first surgical treatment and antibiotic therapy. A second surgical evacuation was necessary. The antibiotic therapy was given for 3 months. Short-time follow-up imaging is necessary irrespective of infection parameters in blood and patient's clinical condition. Especially in parafalcine abscesses a second look may be an option and surgical treatment with evacuation of pus is the treatment of choice if abscess remnants are visualized.
Treatment of cutaneous leishmaniasis with cryosurgery Panagiotopoulos, Antonios; Stavropoulos, Panagiotis G.; Hasapi, Vassiliki ...
International journal of dermatology,
September 2005, Letnik:
44, Številka:
9
Journal Article
Recenzirano
Background The management of cutaneous leishmaniasis with topical methods, if effective, can spare patients from long and costly inpatient treatments.
Methods Seventeen patients with cutaneous ...leishmaniasis were treated with cryosurgery using liquid nitrogen as the cryogen. Two cycles of 10–30 s freezing time were used and repeated at 3‐week intervals.
Results All patients responded well to therapy with excellent cosmetic results and no relapse in any case. Side‐effects were rare.
Conclusions Cutaneous leishmaniasis can be successfully treated with a simple protocol of cryosurgery with minor side‐effects.
Radiochemotherapy (RCT) is an effective treatment for locally advanced non-small cell lung cancer, but can be limited by acute and late toxicities (esophagitis, pneumonitis, and myelosuppression). ...This trial investigated whether pretreatment with amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD), a radioprotector, could reduce the incidence of RCT-induced acute and late toxicities. Between October 1997 and August 1999, 73 patients with previously untreated stage IIIa-IIIb non-small cell lung cancer were randomized to treatment with RCT alone or RCT plus amifostine (300 mg/m(2) daily intravenous infusion). Chemotherapy consisted of either paclitaxel (60 mg/m(2)) or carboplatin (area under the concentration-curve of 2) once weekly during a 5- to 6-week course of conventional radiotherapy given as 2 Gy daily fraction, 5 days a week to a total dose of 55 to 60 Gy. Esophagitis and acute lung toxicity were evaluated during treatment; late lung toxicity was assessed at 3 and 6 months after RCT and was graded from 0 to 4 according to the Radiation Therapy Oncology Group/European Organization for the Research and Treatment of Cancer criteria. Esophageal endoscopy was performed the fourth week during RCT and 1 month after the end of RCT. Endoscopic findings of radiation esophagitis were scored from 0 to 3. There was no significant difference between treatment arms in baseline patient characteristics. A total of 68 patients were evaluable for toxicity and efficacy (RCT group, n = 32; RCT plus amifostine, n = 36). The incidence of grade >or= 3 esophagitis during RCT was significantly lower for patients receiving amifostine than for those receiving RCT alone (38.9% v 84.4%; P <.001). The incidence of grade >or= 3 acute pulmonary toxicity was also significantly reduced in amifostine-treated patients (19.4% v 56.3%; P =.002). At 3 months following RCT, patients treated with amifostine had a significantly lower incidence of pneumonitis than those who received RCT alone (P =.009). Endoscopic grade >or= 2 esophagitis was observed in eight of 15 patients in the RCT group and in three of 18 patients in the RCT plus amifostine group (P =.061). No significant differences in response rates were noted between patients receiving RCT with or without amifostine (P =.498). Amifostine is effective in reducing the incidence of both acute and late toxicities associated with RCT in patients with locally advanced non-small cell lung cancer without compromising antitumor efficacy.
A
bstract
A method for determining the
q
2
dependent
K
¯
∗
0
spin amplitudes of
B
¯
0
→
K
¯
∗
0
μ
+
μ
−
decays through a maximum likelihood fit to data is presented. While current experimental ...techniques extract a limited set of observables in bins of
q
2
, our approach allows for the determination of all observable quantities as continuous distributions in
q
2
. By doing this, the method eliminates the need to correct theory predictions of these observables for
q
2
averaging effects, thus increasing the sensitivity to the effects of physics beyond the Standard Model. Accounting for the symmetries of the angular distribution and using a three parameter ansatz for the
q
2
dependence of the amplitudes, the precision of the angular observables and the sensitivity to new physics is estimated using simulated events. These studies are based on the sample sizes collected by the LHCb experiment during Run-I and expected for Run-II.
Abstract A method for determining the q 2 dependent ... spin amplitudes of ... decays through a maximum likelihood fit to data is presented. While current experimental techniques extract a limited ...set of observables in bins of q 2, our approach allows for the determination of all observable quantities as continuous distributions in q 2. By doing this, the method eliminates the need to correct theory predictions of these observables for q 2 averaging effects, thus increasing the sensitivity to the effects of physics beyond the Standard Model. Accounting for the symmetries of the angular distribution and using a three parameter ansatz for the q 2 dependence of the amplitudes, the precision of the angular observables and the sensitivity to new physics is estimated using simulated events. These studies are based on the sample sizes collected by the LHCb experiment during Run-I and expected for Run-II.
We present first data on event-by-event fluctuations in the average transverse momentum of charged particles produced in Pb+Pb collisions at the CERN SPS. This measurement provides previously ...unavailable information allowing sensitive tests of microscopic and thermodynamic collision models and to search for fluctuations expected to occur in the vicinity of the predicted QCD phase transition. We find that the observed variance of the event-by-event average transverse momentum is consistent with independent particle production modified by the known two-particle correlations due to quantum statistics and final state interactions and folded with the resolution of the NA49 apparatus. For two specific models of non-statistical fluctuations in transverse momentum limits are derived in terms of fluctuation amplitude. We show that a significant part of the parameter space for a model of isospin fluctuations predicted as a consequence of chiral symmetry restoration in a non-equilibrium scenario is excluded by our measurement.
With its large acceptance and particle identification coverage the NA49 experiment (Fig. 1) can study hadron production in a wide range of high energy reactions 1. Originally aimed at examining ...central Pb+Pb collisions for signatures of quark-gluon plasma formation, the scope of the experiment has been enhanced with a systematic study of impact parameter and projectile size dependence, as well as the inclusion of the more elementary p+p and p+A interactions. The question is: are predicted signals of the quark-gluon plasma observed and are there discontinuities which would support the concept of hadronic phase transition?
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