The effects of verapamil (Isoptin Knoll) and calcium glubionate (Calcium Polfa) were studied on the generation of free radicals and activity of anti-oxidant enzymes in rat's gastric mucosa following ...the oral administration of 50% ethyl alcohol. Ethanol in this concentration caused injury to gastric mucosa as well increased the levels of peroxidation products (malonyl dialdehyde, hydroperoxides and conjugated dienes); at the same time a decreased enzyme activity was observed (superoxide dismutase, peroxidase, glutathione peroxidase, glutathione reductase, catalase). Verapamil administered before ethanol increased the ulcerogenic activity of alcohol, increased the activity of the studied antioxidant enzymes (except catalase) and caused the decrease in the levels of peroxidation products in gastric mucosa. Calcium glubionate increased the enzyme activity and showed some protective effect on gastric mucosa.
The severity of damage to gastric mucosa and the levels of malonyl dialdehyde (MDA), hydroperoxides, conjugated dienes (C.D.) as well as the activity of catalase (EC 1.11.1.6), peroxidase (EC ...1.11.1.7), glutathione peroxidase (EC 1.11.1.9) and superoxide dismutase (EC 1.15.1.1.) in rat's gastric mucosa were assessed 2 hours after the oral administration of 50% ethyl alcohol by means of a stainless steel tube. It was found that 50% ethanol administered per os caused numerous ulcerous changes in gastric mucosa, increased the levels of MDA, hydroperoxides, both isoenzymes of superoxide dismutase (Cu, Zn SOD and Mn SOD), glutathione peroxidase and glutathione reductase. The interpretation of the phenomenon was presented, emphasizing the protective role of antioxidant enzymes counteracting the formation of ulcers in gastric mucosa.
The aim of the study was to assess the use of a new Nd:YAG laser--mediLas fibertom--in correcting malignant and benign stenoses of the airways. Eighteen patients were included in the study. In 9 ...these were caused by malignant tumors, in 3 by nonmalignant tumors, in 6 by post-inflammatory stenoses of the airways. Altogether 99 laser sessions were carried out. In patients with malignant diseases complete recanalization was achieved in 6 patients, in 2 partial. One patients did not benefit form the laser procedure. In patients with benign tumors complete recanalization was achieved in all of the patients. In 5 out of 6 patients the post inflammatory stenosis was corrected. Satisfactory results observed after the second, fourth and one year after the initial laser procedure encourage to use this from of therapy in cases of malignant and nonmalignant narrowing of the airways.
