2-Formylpyridine-
para-chloro-phenyl hydrazone (H2FopClPh) and 2-formylpyridine-
para-nitro-phenyl hydrazone (H2FopNO
2Ph) were obtained, as well as their copper(II) and zinc(II) complexes ...Cu(H2FopClPh)Cl
2 (
1), Cu(2FopNO
2Ph)Cl (
2), Zn(H2FopClPh)Cl
2 (
3) and Zn(H2FopNO
2Ph)Cl
2 (
4). Upon re-crystallization in DMSO:acetone conversion of
2 into Cu(2FopNO
2Ph)Cl(DMSO) (
2a) and of
4 into Zn(2FopNO
2Ph)Cl(DMSO) (
4a) occurred. The crystal structures of
1,
2a,
3 and
4a were determined. The electron-withdrawing effect of the
para-nitro group probably makes the metal center more positive and hence more able to accept the fifth ligand. In the case of
4a this effect favors deprotonation at N3, with release of HCl, and attachment of a DMSO molecule to the metal.
In the present work 2-formylpyridine-
para-chloro-phenyl hydrazone (H2FopClPh) and 2-formylpyridine-
para-nitro-phenyl hydrazone (H2FopNO
2Ph) were obtained, as well as their copper(II) and zinc(II) complexes Cu(H2FopClPh)Cl
2 (
1), Cu(2FopNO
2Ph)Cl (
2), Zn(H2FopClPh)Cl
2 (
3) and Zn(H2FopNO
2Ph)Cl
2 (
4). Upon re-crystallization in DMSO:acetone conversion of
2 into Cu(2FopNO
2Ph)Cl(DMSO) (
2a) and of
4 into Zn(2FopNO
2Ph)Cl(DMSO) (
4a) occurred. The crystal structures of
1,
2a,
3 and
4a were determined.
We present the H-band wavelength region of 37 postmaximum light near-infrared spectra of three normal, nine transitional, and four subluminous type. Ia supernovae (SNe Ia), extending from +5. days to ...+20. days relative to the epoch of B-band maximum. We introduce a new observable, the blue-edge velocity, v(edge), of the prominent Fe/Co/Ni-peak H-band emission feature, which is quantitatively measured. The v(edge) parameter is found to decrease over subtype ranging from around -14,000 km s(-1) for normal SNe Ia, to -10,000 km s(-1) for transitional SNe. Ia, down to -5000 km s(-1) for the subluminous SNe. Ia. Furthermore, inspection of the +10 +/- 3 days spectra indicates that v(edge) is correlated with the color-stretch parameter, s(BV), and hence with peak luminosity. These results follow the previous findings that brighter SNe. Ia tend to have Ni-56 located at higher velocities as compared to subluminous objects. As v(edge) is a model-independent parameter, we propose it can be used in combination with traditional observational diagnostics to provide a new avenue to robustly distinguish between leading SNe. Ia explosion models.
Abstract
Background
In addition to endoscopic evaluation, a consistent set of studies has demonstrated an important role for histology in ulcerative colitis (UC) patients, both for diagnosis and in ...follow-up, while in Crohn’s disease (CD) evidence are scantier. The aim of the study was to investigate the different role of histological evaluation in CD and UC patients, in a single referral centre.
Methods
Data of 86 IBD patients in follow-up at IBD Outpatient Clinic in San Giovanni-Addolorata Hospital in Rome (2016–2017) were retrospectively evaluated. We included only patients (n = 30 UC and 30 CD) who had a visit and a colonoscopy within 1 month, and who had a 1-year follow-up visit. Active symptoms, endoscopic activity, histological inflammatory activity and specificity, and flare occurrence at 1 year of follow-up, were considered as dichotomous variables (0–1). In the histological report, neutrophilic infiltrate, criptitis and criptic abscesses were considered features of active inflammation, and basal plasmocytosis, mucin depletion, structural disarray and granulomata were considered specific features for IBD. Moreover, in patients with established diagnosis of IBD (12 CD and 14 UC), the presence of specific histological features at the first colonoscopy was evaluated, to investigate the role of histology for the initial diagnosis in those patients.
Results
In patients in follow-up, a significant higher rate of UC patients showed full concordance (specificity and activity) between histological and endoscopic evaluation comparing with CD patients 26/30(87%) vs. 12/30(40%), p < 0.005. In IBD patients in follow-up, 72% of UC and 57% of CD patients showed specific histological IBD features. Eighty-four per cent of UC and 58% of CD patients displayed concordance between endoscopic and histological inflammatory activity. In UC, but not in CD, both endoscopic and histological inflammatory activity correlated with the presence of active symptoms of disease (p < 0.001 and p < 0.05, respectively). No significant different rate of flare at 1 year was observed in patients with endoscopic/histological features or symptoms of active vs. inactive disease, both in UC and CD. In the first colonoscopy performed for suspected IBD, specific diagnostic features were found in 86% of UC and 67% of CD patients.
Conclusions
in UC patients, histological evaluation consistently correlated with endoscopic and clinical features of active disease, and showed an elevated specificity both for the diagnosis and in the follow-up. In CD patients, correlation with histology and endoscopic/clinical features was less impressive. In a referral centre histological evaluation has a potential relevant role in IBD diagnosis and follow-up.
We present the simultaneous Swift and Fermi observations of the bright GRB 100728A and its afterglow. The early X-ray emission is dominated by a vigorous flaring activity continuing until 1 ks after ...the burst. In the same time interval, high-energy emission is significantly detected by the Fermi/Large Area Telescope. Marginal evidence of GeV emission is observed up to later times. We discuss the broadband properties of this burst within both the internal and external shock scenarios, with a particular emphasis on the relation between X-ray flares, the GeV emission, and a continued long-duration central engine activity as their power source.
The X-ray satellite SAX, a major program of the Italian Space Agency with participation of the Netherlands Agency for Aereospace Programs, was launched on April 30 1996 from Cape Canaveral. After ...launch it was renamed BeppoSAX in honour of Giuseppe (Beppo) Occhialini. The payload is characterized by a very wide spectral coverage from 0.1 to 300 keV, with well balanced performances both from its low and high energy instrumentation. Its sensitivity will allow the exploitation of the full band for weak sources (1/20 of 3C 273), opening new perspectives in the study of spectral shape and variability of several classes of objects. Furthermore, the presence of wide field cameras will allow monitoring of the long term variability of sources down to 1 mCrab and the discovery of X-ray transient phenomena. In this paper we describe the main aspects of the mission, the operations, the scientific capabilities of the instruments and the scientific objectives.
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