We report upon the performance of an analog hadron calorimeter prototype, where plastic scintillator tiles are read out with wavelength-shifting fibers coupled to avalanche photodiodes. This ...prototype configuration has been tested using a positron beam at DESY with energies between 1 and 6
GeV. We present different detector calibration methods, show measurements for noise, linearity, and energy resolution and discuss gain monitoring with an LED system. The results are in good agreement with our simulation studies and previous measurements using silicon photomultiplier readout.
We report on the design, construction and performance of a prototype for a high-granularity tile hadronic calorimeter for a future international linear collider detector. Scintillating tiles are read ...out via wavelength-shifting fibers that guide the scintillation light to a novel photodetector, the silicon photomultiplier. A prototype has been tested using a positron test beam at DESY. The results are compared with a reference prototype calorimeter equipped with multichannel vacuum photomultipliers. Detector calibration, noise, linearity and stability are discussed, and the energy response in a 1–6
GeV positron beam is compared with simulations. The present results demonstrate that the silicon photomultiplier is well-suited as photodetectors in calorimeters and thus has been selected for the construction of a
1
m
3
calorimeter prototype to operate in hadron beams.
We present a study of the response of the highly granular Digital Hadronic Calorimeter with steel absorbers, the Fe-DHCAL, to positrons, muons, and pions with momenta ranging from 2 to 60GeV/c. ...Developed in the context of the CALICE collaboration, this hadron calorimeter utilises Resistive Plate Chambers as active media, interspersed with steel absorber plates. With a transverse granularity of 1×1cm2 and a longitudinal segmentation of 38 layers, the calorimeter counted 350,208 readout channels, each read out with single-bit resolution (digital readout). The data were recorded in the Fermilab test beam in 2010–11. The analysis includes measurements of the calorimeter response and the energy resolution to positrons and muons, as well as detailed studies of various shower shape quantities. The results are compared to simulations based on Geant4, which utilise different electromagnetic and hadronic physics lists.
The authors analyzed epidemiologically two cases of trichophytosis caused by zoophilic dermatophytes in persons living in the city. The first case was a male aged 43, suffering from trichophytosis on ...the right side of his neck. The patient was infected at work from guinea pigs. Trichophyton mentagrophytes varietas granulosum was the etiological agent. The second case occurred in a female aged 29, suffering from trichophytosis on her left arm. Trichophyton verrucosum was the causal agent. A horse was the source of infection.
1354 health workers of the District Institute of National Health in Pardubice were asked in a survey about the incidence of risk factors of non-infectious diseases in their life style. One quarter of ...the health workers live a healthy life by influencing risk factors in a favourable way. The results call for a more intense activity as regards elimination of risk factors in order to promote better health.
Markers of Recurrence and Long-Term Morbidity in Craniopharyngioma: A Systematic Analysis of 171 Patients on behalf of the Craniopharyngioma Study Group: Prs. and Drs. Anne Bachelot, Anne-Laure Boch, Raja Brauner, Jean-Claude Carel, Anne Colobert, Hélène Crosnier, Vonny Derennes, Pierre Doyard, Françoise Getin, Isabelle Guilhem, Muriel Hoang, Claire Josseaume, Julianne Leger, Sylvie Nivot, Christian Pauwels, Graziella Pinto, Michel Polak, Raphaël Rappaport, Dinane Samara, Sylvie Sauvion, Caroline Thalassinos, and Elisabeth Thibaud; Gautier, Alain; Godbout, Ariane ...
The journal of clinical endocrinology and metabolism,
04/2012, Letnik:
97, Številka:
4
Journal Article
Recenzirano
Odprti dostop
Context:
Craniopharyngiomas are often associated with an unfavorable prognosis, but data on their long-term consequences are sparse.
Objective:
The aim of the study was to identify markers of ...recurrence and factors associated with compromised social rehabilitation and altered quality of life in a large cohort of patients with either childhood-onset (CO) or adult-onset craniopharyngioma.
Methods:
Retrospective analysis was performed for 171 patients treated for craniopharyngioma in two academic centers in France between 1972 and 2009. For each subject, data were collected concerning clinical presentation, imaging features, visual sequelae, endocrine and metabolic impact, treatment modalities (surgery, radiotherapy), recurrence-free survival rate, and social insertion, as well as answers to the WHO-QOL BREF questionnaire.
Results:
A total of 65 CO and 106 adult-onset patients were reviewed. If CO was diagnosed before the age of 10 yr, this was associated with a higher incidence of obesity, blindness, and panhypopituitarism, and only 40.7% of subjects had adequate work or school attendance compared to 72.4% of patients with later disease onset. Initial symptoms of intracranial hypertension (SIHT), pterional surgery, and multiple surgery were associated with obesity and poorer social insertion. No determinant of quality of life was identified. In the subgroup of patients treated in the 1990s and later, the progression rate was 59.4% in patients with residual tumor on magnetic resonance imaging compared with a 19.8% recurrence rate in the group with apparently complete resection. Recurrence/progression correlates significantly with male gender, early onset (before 10 yr), and SIHT, but only SIHT at presentation remained a significant predictor with multivariate analysis.
Conclusions:
Craniopharyngioma continues to be associated with severe outcomes. Higher morbidity rates are found in patients with early-onset disease (before 10 yr), initial SIHT, or in whom pterional surgery was required. Markers of recurrence are difficult to identify, with SIHT being the most powerful predictor.
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