Three to five hundred million cases of malaria occur annually, causing over one to two million deaths. Malaria is one of the leading causes of fever, resulting from travel in tropical or subtropical ...countries. That risk is very high, especially for sailors. By the nature of their job they cannot avoid malarial regions and generally suffer from the lack of medical help aboard, insufficient knowledge of preventive measures, and lack of up-to-date information about chloroquine resistant areas.
Retrospective analysis embraced all cases of malaria among seafarers employed in the years 1990-1993 by the Croatian sea carrier Losinjska Plovidba, and cases treated at the Clinic for Infectious Diseases, Rijeka, in the same period.
In that period, among seafarers treated in our Port Health Office there were registered 23 cases of malaria; 19 cases among sailors and 4 among tourists, all of them aboard merchant ships. Among seafarers treated in the Clinic for Infectious Diseases from 1990-1993 there were 13 malaria patients, 12 of them sailors and 1 tourist.
The aim of this work is to study the morbidity of malaria on board ships owned by the Croatian shipping company Losinjska Plovidba in the 4-year period 1990-1993 and point to the lack of a health system for their health protection. It can be concluded that the severity of malaria, the number of complications, the period of disablement for work, permanent health damage in a marked number of young persons on duty abroad, all clearly demonstrate the individual and social costs of this disease in Croatia and the maritime community worldwide.
Procjenjuje se da virusne infekcije pridonose nastanku 15 – 20 % svih malignih tumora ljudi. Kao obligatorni intracelularni paraziti, virusi kodiraju proteine koji reprogramiraju signalne puteve ...odgovorne za kontrolu proliferacije, diferencijacije, smrti stanice, genomskog integriteta, kao i prepoznavanja od strane imunološkog sustava. Virusni sustavi podržavaju koncept da je za razvoj tumora potrebna akumulacija međusobno povezanih događaja. Virusi koji su do sada prihvaćeni
kao etiološki čimbenici ljudskih malignoma uključuju hepatitis B virus, Epstein-Barr virus,
humani papiloma virus, virus leukemije ljudskih T-stanica, hepatitis C virus, te još nekoliko ljudskih onkogenih virusa. Obično protekne niz godina od infekcije do razvoja tumora i većina inficiranih
osoba ne razvije rak, iako imunološki kompromitirane osobe pokazuju veći rizik za nastanak
tumora povezanih s virusima. Malo je vjerojatno da je virus sam dovoljan da transformira normalnu stanicu u tumorsku. Vjerojatnija je mogućnost da kombinirano djelovanje virusnih proteina i mutacije staničnih gena zajedno vode tumorogenezi.
We report clinically rare and serious adverse reactions that occurred after the co-administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible ...bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterials, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
Već od početka svoga nastanka Republika Hrvatska se našla u ratnom vihoru, bila je izložena agresiji od strane Srbije i JNA kao i pobuni dijela građana srpske nacionalnosti. Cilj pobune je bio ...provođenje različitih subverzivno-terorističkih aktivnosti, činjenje nasilnih i kriminalnih akata te stvaranje općeg kaosa, a u konačnici rušenje legalno izabrane vlasti. Najveći dio kažnjivih djela: ubojstva, razbojništva, progoni, prijetnje, razaranje domova, paljevine, rušenje kulturnih i duhovnih vrednota i granatiranje gradova počinjeni su početkom agresije i trajali su različitim intenzitetom tijekom čitavog rata. Sva ta kriminalna djela činjena su iz osvajačkih pobuda, iz osvete, mržnje i netrpeljivosti prema građanima Hrvatske, a kako su imali terorističku osnovu, nazvali smo ih ratni zločini s obilježjem terorizma. Da bismo objasnili ovaj fenomen, učinili smo uvid u podatke koji su rezultirali iz istraživačkih aktivnosti policijskih službi te smo primijenili deskriptivnu analizu klasifikacijskog tipa. Naša osnovna hipoteza je bila da su ratni zločini s obilježjem terorizma po motivaciji, načinu počinjenja i ciljevima spram žrtava imali višeslojan karakter od čisto političko-ideoloških namjera osvajanja teritorija do činjenja nasilničko-kriminalnih akata prema ljudima i njihovoj imovini.
To investigate the clinical and bacteriological efficacy of 5- and 7-day pefloxacin therapy in patients with acute infectious diarrhoea.
Eighty-two adult patients with acute infectious diarrhoea were ...randomly divided into three groups: group 1 (n = 20) received 5 days of treatment with pefloxacin, group 2 (n = 27) was assigned to a 7-day pefloxacin protocol, and group 3 (n = 35) was treated symptomatically. The daily dose of pefloxacin was 400mg orally. Clinical and bacteriological response was analysed on the third, fifth and seventh days of treatment as well as 1 and 4 weeks after the end of treatment. The study was an open-labelled, prospective clinical trial.
In the 47 patients (100%) of both pefloxacin groups a clinical improvement was noted on the third day compared with the control group, where this occurred on day 7. Bacteriological eradication was verified on the fifth day in 18 patients (90%) from group 1 and in 25 patients (93%) from group 2; they all had negative stool cultures 1 and 4 weeks after therapy was completed. Only 22 patients (63%) in the control group had negative stool cultures on the seventh day of treatment, but 4 weeks later all of them were negative.
There was no difference in clinical (p = 0.232) and bacteriological (p = 0.972) efficacy between the 5- and 7-day pefloxacin treatment protocols. However, both protocols differed significantly in clinical improvement (p < 0.001) and bacteriological eradication (p = 0.017) from the control group.
Clinical forms of Lyme disease in Gorski Kotar have occurred only sporadically, in contrast to the northwestern Croatia and the neighboring areas of Slovenia, which are well-known Lyme borreliosis ...endemic regions. Our aim was to assess the level of sero-prevalence of Borrelia burgdorferi sensu lato in a high-risk population of forestry workers in the mountainous region of Gorski Kotar, Croatia, and compare it with the sero-prevalence in the residents of that area and the neighboring littoral region.
A sero-epidemiological study was conducted on 520 healthy subjects, divided in 3 groups: the first group included 234 forestry workers, residents of Gorski Kotar, the second 100 residents of various professions in the same region, and the third 186 subjects of various professions from the neighboring littoral region. The sera were collected during the winters of two successive years, 1997 and 1998. Lyme borreliosis serology was performed by indirect immunofluorescence assay. Sera from 10 hunting dogs from Gorski Kotar were also analyzed.
The IgG antibodies to B. burgdorferi sensu lato were found in 11 examinees (4.7%) from the group of forestry workers, in 3 (3%) from the second group, and in 5 (2.7%) from the third group. Four out of 10 dogs (40%) had IgG antibodies against B. burgdorferi.
Our results show that the forest and mountainous area of Gorski Kotar, Croatia, has the characteristics of a low sero-prevalence area, in contrast to the endemic neighboring areas.
Aktinomikoza predstavlja rijetku kroničnu infekciju uzrokovanu anaerobnom, Gram pozitivnom bakterijom koja pripada rodu Actinomyces. U ovom smo radu prikazali slučaj aktinomikoze temporalne kosti i ...meningitisa uzrokovanog Aktinomicetama te limfadenitisa vrata kod imunokompetentne bolesnice s anamnezom
kroničnog supurativnog otitisa nakon traumatske perforacije bubnjića
starijeg datuma. Liječenje je uspješno provedeno kombiniranom kirurškom i dugotrajnom antimikrobnom terapijom. Ovim prikazom želimo skrenuti pozornost na meningitis kojeg uzrokuje Actinomyces spp. te kojeg je, iako je rijedak, potrebno uključiti u diferencijalnu dijagnozu kroničnog meningitisa, osobito kod pacijenata s kroničnom upalom srednjeg uha i paranazalnih sinusa. Jednako tako, želimo skrenuti pozornost i na ostale manifestacije ove rijetke bolesti.
We report clinically rare and serious adverse reactions that occurred after the co-administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible ...bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterials, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection and/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.
Epidemiološke odlike hepatitisa A bile su dostatne za njegovo razlikovanje od ostalih virusnih hepatitisa. Posljednjih godina, međutim, javile su se nove rizične skupine i putovi prijenosa virusa. ...Ispitivanja na riječkom području pokazala su da se u potpunosti promijenila i dobna predispozicija bolesnka i najčešće se bolest registrira u skupini od 30. do 40. godine starosti.
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