We present the discovery of ASASSN-18ey (MAXI J1820+070), a new black hole low-mass X-ray binary (LMXB) discovered by the All-Sky Automated Survey for SuperNovae (ASAS-SN). A week after ASAS-SN ...discovered ASASSN-18ey as an optical transient, it was detected as an X-ray transient by MAXI/GCS. Here, we analyze ASAS-SN and Asteroid Terrestrial-impact Last Alert System pre-outburst optical light curves, finding evidence of intrinsic variability for several years prior to the outburst. While there was no long-term rise leading to the outburst, as has been seen in several other systems, the start of the outburst in the optical preceded that in the X-rays by 7.20 0.97 days. We analyze the spectroscopic evolution of ASASSN-18ey from pre-maximum to >100 days post-maximum. The spectra of ASASSN-18ey exhibit broad, asymmetric, double-peaked H emission. The Bowen blend (λ 4650 ) in the post-maximum spectra shows highly variable double-peaked profiles, likely arising from irradiation of the companion by the accretion disk, typical of low-mass X-ray binaries. The optical and X-ray luminosities of ASASSN-18ey are consistent with black hole low-mass X-ray binaries, both in outburst and quiescence.
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•Nanomedicine shows potential to improve brain drug delivery.•Chemotherapeutics have been encapsulated into nanocarriers for glioblastoma treatment.•Doxorubicin and liposomes are the ...most frequent drug and carrier tested preclinically.•Several nanocarriers have entered clinical trials for glioblastoma treatment.
Even though substantial advances in understanding glioma pathogenesis have prompted a more rational design of potential therapeutic strategies, glioblastoma multiforme remains an incurable disease with the lowest median overall survival among all malignant brain tumours. Therefore, there is a dire need to find novel drug delivery strategies to improve the current dismal survival outcomes. In this context, nanomedicine offers an appealing alternative as it shows potential to improve brain drug delivery. Accordingly, we here review nanomedicine-based drug delivery strategies tested in orthotopic animal models of glioblastoma intended to improve the efficacy of the drug candidates that are currently used in the clinical setting or that have entered clinical trials for the treatment of glioblastoma multiforme. We also outline the future perspectives of nanotechnology to provide emerging glioblastoma treatment with broad translational clinical potential based on the nanocarriers that have already entered the clinical trials stage for the treatment of malignant glioma.
The reference evapotranspiration (ETo) is an essential component in hydrological and ecological processes. The objective of this research is to develop an explicit model to estimate ETo only using ...commonly measurable meteorological parameters such as relative humidity, air temperature, and wind speed, where the measurements corresponding to solar radiation are omitted. The model was generated using Genetic Programming (GP), evaluated, and validated with reference data ETo using FAO56-PM. This reference data was obtained from different climates (warm-temperate and arid-warm) and latitudes, acquired from CIMIS stations in the state of California, United States, and the El Porvenir station in the state of Coahuila, located in north-central Mexico. After applying the proposed methodology, a total of 3754 results were generated, demonstrating a significant improvement in the estimation of ETo compared to the Hargreaves-Samani model. A particularly noteworthy result revealed that our approach outperformed the Hargreaves-Samani model in the training phase by 27%, and in the testing phase by 16%, on average. In order to achieve a generalized model, a dataset encompassing meteorological stations in two different climates (warm-temperate and arid-warm) and various latitudes was utilized. The obtained outcome unveiled a highly effective model for estimating ETo in diverse climatic contexts, eliminating the need for local adjustments. This model significantly surpassed the Hargreaves-Samani model, exhibiting superior performance by 17% during the training phase and 18% during the testing phase. These results conclusively underscore the capability of our approach to provide more accurate and reliable ETo estimates. These results conclusively underscore the capability of our approach to provide more accurate and reliable ETo estimates. Finally, to validate the model, four different datasets with climates similar to those used for model creation (warm-temperate, warm-arid) and different latitudes were employed. The validation stage results clearly indicate the superiority of our reference evapotranspiration ETo11 model over the Hargreaves-Samani model by 51% in warm-temperate climates. For the dataset with arid-warm climate, our model continued to show satisfactory results, surpassing the Hargreaves-Samani model by 8%. GP emerges as an innovative and effective alternative for simplified model development. This approach introduces a novel paradigm that facilitates the efficient development of models, standing out for its simplicity and effectiveness in generating solutions.
The disinfection of 100 mL of synthetic water containing 7 mM Na2SO4 with 106 CFU mL−1 of either Gram-negative or Gram-positive bacteria has been studied by electrochemical oxidation. The ...electrolytic cell was a stirred tank reactor equipped with a boron-doped diamond (BDD) anode and a stainless steel cathode and the trials were performed at acidic and neutral pH, at 33.3 mA cm−2 and 25 °C. Reactive oxygen species, pre-eminently hydroxyl radicals, were efficiently produced in both media from water oxidation at the BDD anode and the bacteria concentration was reduced by ≥ 5 log units after 60 min of electrolysis, thus constituting a good chlorine-free disinfection treatment. All the inactivation kinetics were described by a logistic model, with no significant statistical differences between acidic and neutral suspensions. The electrochemical disinfection with BDD was very effective for Gram-negative bacilli like Escherichia coli and Pseudomonas aeruginosa and Gram-positive ones like Bacillus atrophaeus, whereas the Gram-positive cocci Staphylococcus aureus and Enterococcus hirae were more resistant. Thus, the latter organisms are a better choice than E. coli as process indicators. Scanning electron microscopy highlighted a transition from initial cells with standard morphology supported on clean filters to inactivated cells with a highly altered morphology lying on dirty filters with plenty of cellular debris. Larger damage was observed for Gram-negative cells compared to Gram-positive ones. The inactivation effect could then be related to the chemical composition of the outer layers of the cell structure along with the modification of the transmembrane potentials upon current passage.
•Electrochemical disinfection using BDD anode: effect on Gram-negative and Gram-positive bacteria.•Rapid and total inactivation of bacilli Escherichia coli, Pseudomonas aeruginosa and Bacillus atrophaeus.•Slower but almost total inactivation of cocci Staphylococcus aureus and Enterococcus hirae.•Description of all inactivation kinetics using a logistic model.•Significant surface damage found in all inactivated cells as observed by SEM.
We present 855 cataclysmic variable candidates detected by the Catalina Real-time Transient Survey (CRTS) of which at least 137 have been spectroscopically confirmed and 705 are new discoveries. The ...sources were identified from the analysis of five years of data, and come from an area covering three quarters of the sky. We study the amplitude distribution of the dwarf novae cataclysmic variables (CVs) discovered by CRTS during outburst, and find that in quiescence they are typically 2 mag fainter compared to the spectroscopic CV sample identified by the Sloan Digital Sky Survey. However, almost all CRTS CVs in the SDSS footprint have ugriz photometry. We analyse the spatial distribution of the CVs and find evidence that many of the systems lie at scale heights beyond those expected for a Galactic thin disc population. We compare the outburst rates of newly discovered CRTS CVs with the previously known CV population, and find no evidence for a difference between them. However, we find significant evidence for a systematic difference in orbital period distribution. We discuss the CVs found below the orbital period minimum and argue that many more are yet to be identified among the full CRTS CV sample. We cross-match the CVs with archival X-ray catalogues and find that most of the systems are dwarf novae rather than magnetic CVs.
Nanomedicine and drug delivery technologies play a prominent role in modern medicine, facilitating better treatments than conventional drugs. Nanomedicine is being increasingly used to develop new ...methods of cancer diagnosis and treatment, since this technology can modulate the biodistribution and the target site accumulation of chemotherapeutic drugs, thereby reducing their toxicity. Regenerative medicine provides another area where innovative drug delivery technology is being studied for improved tissue regeneration. Drug delivery systems can protect therapeutic proteins and peptides against degradation in biological environments and deliver them in a controlled manner. Similarly, the combination of drug delivery systems and stem cells can improve their survival, differentiation, and engraftment. The present review summarizes the most important steps carried‐out by the group of Prof Blanco‐Prieto in nanomedicine and drug delivery technologies. Throughout her scientific career, she has contributed to the area of nanomedicine to improve anticancer therapy. In particular, nanoparticles loaded with edelfosine, doxorubicin, or methotrexate have demonstrated great anticancer activity in preclinical settings of lymphoma, glioma, and pediatric osteosarcoma. In regenerative medicine, a major focus has been the development of drug delivery systems for brain and cardiac repair. In this context, several microparticle‐based technologies loaded with biologics have demonstrated efficacy in clinically relevant animal models such as monkeys and pigs. The latest research by this group has shown that drug delivery systems combined with cell therapy can achieve a more complete and potent regenerative response. Cutting‐edge areas such as noninvasive intravenous delivery of cardioprotective nanomedicines or extracellular vesicle‐based therapies are also being explored.
This article is categorized under:
Therapeutic Approaches and Drug Discovery > Emerging Technologies
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Timeline representing key contributions performed by the group of Prof Blanco‐Prieto in the field of nanomedicine and drug delivery
The aim of this study was to analyze the mediation role of cardiorespiratory fitness and waist circumference in the association between muscular strength and cardiometabolic risk. A cross‐sectional ...study involved first‐year college students (n = 370) from a Spanish public university was performed. We measured weight, height, waist circumference, blood pressure, biochemical variables, maximum handgrip strength assessment, and cardiorespiratory fitness. We calculated handgrip dynamometry/weight and a previously validated cardiometabolic risk index. Analysis of covariance models was conducted to test differences in cardiometabolic risk values across muscular strength, cardiorespiratory fitness, and waist circumference categories, controlling for confounders. Hayes’ PROCESS macro was used for the multiple mediation analysis. The relationship between muscular strength and cardiometabolic risk did not remain significant (c′ = 1.76 1.4; P > .05) in a multiple serial bootstrapped mediation model including cardiorespiratory fitness and waist circumference as mediators when controlling for age and sex. According to the indirect effect, the significant paths in the model mediating this relationship between muscular strength and cardiometabolic risk index were as follows: muscular strength → waist circumference → cardiometabolic risk index (−4.899; 95% CI: −6.690; −3.450) and muscular strength → cardiorespiratory fitness → waist circumference → cardiometabolic risk index (−0.720; 95% CI: −1.316; −0.360). Both cardiorespiratory fitness and waist circumference mediate the association between muscular strength and cardiometabolic risk in young adults. Thus, our results place cardiorespiratory fitness and waist circumference as the main targets of physical activity programmes aimed at preventing cardiometabolic diseases.
Serum Sclerostin in Alcoholics: A Pilot Study GONZALEZ-REIMERS, E; MARTIN-GONZALEZ, C; DE LA VEGA-PRIETO, M. J ...
Alcohol and alcoholism (Oxford),
05/2013, Letnik:
48, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Sclerostin is an endogenous inhibitor of the Wnt/β-catenin pathway secreted by osteocytes, which inhibits osteoblast function, differentiation and survival. As a consequence, sclerostin tends to ...decrease bone mass. Alcoholics frequently present osteoporosis, mainly due to decreased bone synthesis. The behaviour of sclerostin in these patients is unknown. The aim of this work was to analyse the relationship between serum sclerostin levels and bone mineral density (BMD), ethanol consumption, nutritional status, liver function derangement and biomarkers of bone homeostasis in alcoholic patients.
We included 31 alcoholic patients, of whom 11 were infected with Hepatitis C virus (HCV) and 7 age and sex-matched controls. All underwent densitometry, and serum sclerostin, osteocalcin, collagen telopeptide, parathyroid hormone (PTH), vitamin D, cortisol and testosterone were determined.
Sclerostin levels were significantly higher in patients (30.95 ± 18.91 pmol/l) than controls (t = 4.4; P < 0.001), especially in non-HCV patients; they showed an inverse correlation with osteocalcin, prothrombin activity and serum albumin, and a direct correlation with bilirubin and telopeptide, but not with BMD, nutritional status or ethanol intake.
Serum sclerostin was raised in alcoholic patients, and it correlated with decreased markers of bone synthesis and increased markers of bone breakdown. The elevation in sclerostin levels was clearly related with liver function, but not with ethanol intake, nutritional status or concomitant HCV infection.
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