This study presents a space vector pulsewidth modulation algorithm for five-phase converters operating in the overmodulation region that forbids the use of zero vectors, covering the whole ...overmodulation range and providing minimum x - y voltages. Avoiding zero vectors reduces the content of low-order current harmonics and, at the same time, reduces the common-mode voltage (CMV) by 40%. The method is first implemented using medium and large voltage space vectors, showing good performance in terms of current harmonic content. Then, the algorithm is applied to the case when four large vectors are used, further reducing the peak-to-peak CMV by 80% and still demonstrating a satisfactory performance. Both methods are experimentally compared to existing overmodulation algorithms obtaining better current quality and lower peak-to-peak CMV.
Abstract
We present Atacama Large Millimeter/sub-millimeter Array Cycle-2 observations of the HBC 494 molecular outflow and envelope. HBC 494 is an FU Ori-like object embedded in the Orion A cloud ...and is associated with the reflection nebulae Re50 and Re50N. We use 12CO, 13CO and C18O spectral line data to independently describe the outflow and envelope structures associated with HBC 494. The moment-1 map of the 12CO emission shows the widest outflow cavities in a Class I object known to date (opening angle ∼150°). The morphology of the wide outflow is likely to be due to the interaction between winds originating in the inner disc and the surrounding envelope. The low-velocity blueshifted and redshifted 13CO and C18O emission trace the rotation and infall motion of the circumstellar envelope. Using molecular line data and adopting standard methods for correcting optical depth effects, we estimate its kinematic properties, including an outflow mass of the order of 10−1 M⊙. Considering the large estimated outflow mass for HBC 494, our results support recent theoretical work suggesting that wind-driven processes might dominate the evolution of protoplanetary discs via energetic outflows.
First Resolution of Microlensed Images Dong, Subo; Mérand, A.; Delplancke-Ströbele, F. ...
The Astrophysical journal,
01/2019, Letnik:
871, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Abstract
We employ Very Large Telescope Interferometer GRAVITY to resolve, for the first time, the two images generated by a gravitational microlens. The measurements of the image separation
mas, and ...hence the Einstein radius
θ
E
= 1.87 ± 0.03 mas, are precise. This demonstrates the robustness of the method, provided that the source is bright enough for GRAVITY (
K
≲ 10.5) and the image separation is of order of or larger than the fringe spacing. When
θ
E
is combined with a measurement of the “microlens parallax”
, the two will together yield the lens mass and lens–source relative parallax and proper motion. Because the source parallax and proper motion are well measured by
Gaia
, this means that the lens characteristics will be fully determined, whether or not it proves to be luminous. This method can be a powerful probe of dark, isolated objects, which are otherwise quite difficult to identify, much less characterize. Our measurement contradicts Einstein’s prediction that “the luminous circle i.e., microlensed image cannot be distinguished” from a star.
Abstract Despite the great advances that have been made in osteosarcoma therapy during recent decades, recurrence and metastases are still the most common outcome of the primary disease. Current ...treatments include drugs such as doxorubicin (DOX) that produce an effective response during the initial exposure of tumor cells but sometimes induce drug resistance within a few cycles of chemotherapy. New therapeutic strategies are therefore needed to overcome this resistance. To this end, DOX was loaded into lipid nanoparticles (LN) and its efficacy was evaluated in commercial and patient-derived metastatic osteosarcoma cell lines. DOX efficacy was heavily influenced by passage number in metastatic cells, in which an overexpression of P-gp was observed. Notably, DOX-LN overcame the resistance associated with cell passage and improved DOX efficacy fivefold. Moreover, when DOX was co-administered with either free or encapsulated edelfosine (ET), a synergistic effect was observed. This higher efficacy of the combined treatment was found to be at least partially due to an increase in caspase-dependent cell death. The combination of DOX and ET is thus likely to be effective against osteosarcoma.
ABSTRACT
As part of the 100IAS survey, a program aimed to obtain nebular-phase spectra for a volume-limited and homogeneous sample of Type Ia supernovae (SNe Ia), we observed ASASSN-18tb (SN 2018fhw) ...at 139 d past maximum light. ASASSN-18tb was a fast-declining, sub-luminous event that fits well within the observed photometric and spectroscopic distributions of the SN Ia population. We detect a prominent H α emission line (LH α = 2.2 ± 0.2 × 1038 ergs s−1) with FWHM ≈ 1100 km s−1 in the nebular-phase spectrum of this SN Ia. High-luminosity H α emission (LH α ≳ 1040 ergs s−1) has previously been discovered in a rare class of SNe Ia-like objects showing circum-stellar medium (CSM) interactions (SNe Ia–CSM). They predominantly belong to overluminous (Mmax < −19 mag in optical) 1991T-like SNe Ia and are exclusively found in star-forming galaxies. By contrast, ASASSN-18tb is a sub-luminous SN Ia (MB,max ∼ −17.7 mag) found in an early-type galaxy dominated by old stellar populations. We discuss possible origins for the observed hydrogen. Of the 75 SNe Ia for which we have so far obtained nebular spectra in 100IAS, no other SN shows a ${\sim } 1000 \, {\rm km\, s^{-1}}$ H α emission line with comparable line luminosity as ASASSN-18tb, emphasizing the rarity of such emission in the nebular phase. Based on preliminary results from our survey, the rate for ASASSN-18tb-like nebular H α emission could be as high as ${\sim } 10{{\ \rm per\ cent}}$ among sub-luminous SNe Ia.
When James Parkinson described the classical symptoms of the disease he could hardly foresee the evolution of our understanding over the next two hundred years. Nowadays, Parkinson's disease is ...considered a complex multifactorial disease in which genetic factors, either causative or susceptibility variants, unknown environmental cues, and the potential interaction of both could ultimately trigger the pathology. Noteworthy advances have been made in different fields from the clinical phenotype to the decoding of some potential neuropathological features, among which are the fields of genetics, drug discovery or biomaterials for drug delivery, which, though recent in origin, have evolved swiftly to become the basis of research into the disease today. In this review, we highlight some of the key advances in the field over the past two centuries and discuss the current challenges focusing on exciting new research developments likely to come in the next few years. Also, the importance of pre-motor symptoms and early diagnosis in the search for more effective therapeutic options is discussed.
Background and aims Carpobrotus edulis invades coastal areas throughout the world, decreasing plant diversity and hampering restoration efforts by changing soil properties. Some of its effects on ...soils are known but there is a knowledge gap about the effects in rocky areas and micronutrients that we aimed to fill for dunes and rocky habitats with temperate-humid climate. Methods We compared invaded vs non-invaded paired plots in two dune and two rocky areas by measuring 18 variables in litter and 24 in soils (0–5 and 5–10 cm layers). Results Invasion effects increased with the accumulated alien necromass, decreased with soil depth and are substrate-dependent: soil pH, AI, Fe and P increased in dunes, while these variables and Mg, Cu and Zn decreased in rocky sites. Carpobrotus necromass is richer in Mg and Ca and poorer in AI, Co, Cu, Fe, Ni and Zn than native necromass. Conclusions Invader effects on soils are largely mediated by its necromass, which has contrasting characteristics with the autochthonous necromass. Carpobrotus edulis ability to discriminate against Al uptake, while favouring Mg and Ca uptake, and its lower requirement (or higher resorption) of key micronutrients (Co, Cu, Fe, Ni, Zn) than native vegetation could partly explain its invasiveness.
ABSTRACT
We analyse the 476 SN Ia host galaxies from the All-Sky Automated Survey for Supernova (ASAS-SN) Bright Supernova Catalogues to determine the observed relative Type Ia supernova (SN) rates ...as a function of luminosity and host galaxy properties. We find that the luminosity distribution of the SNe Ia in our sample is reasonably well described by a Schechter function with a faint-end slope α ≈ 1.5 and a knee M⋆ ≈ −18.0. Our specific SN Ia rates are consistent with previous results but extend to far lower host galaxy masses. We find an overall rate that scales as (M⋆/1010 M⊙)α with α ≈ −0.5. This shows that the specific SN Ia rate continues rising towards lower masses even in galaxies as small as log (M⋆/M⊙) ≲ 7.0, where it is enhanced by a factor of ∼10–20 relative to host galaxies with stellar masses ∼1010 M⊙. We find no strong dependence of the specific SN Ia rate on the star formation activity of the host galaxies, but additional observations are required to improve the constraints on the star formation rates.
The construction engineering and management sector is facing rapid technological disruption due to the extensive adoption of digital tools. The main aim of this research was to assess the accuracy ...and usefulness of web-based instruments used for the evaluation and mensuration of built environment characteristics. Through on-site visits and two web-based tools, a digital management system based on fuzzy logic was used to evaluate the functional service life of two heritage timber buildings in Valdivia (Chile). The assessments of 40 professional experts (4 on-site visual inspections and 36 virtual inspections) were compared to evaluate the relative accuracy and usefulness of the on-site and web-based instruments. Web-based audits, which used Google Street View and Google Maps, tended to agree strongly with on-site audits on the functional degradation of the timber structures (vulnerabilities and external hazard affections). While web-based tools do not offer a perfect substitute for on-site audits, they do allow for preliminary audits to be performed accurately from remote locations, potentially saving time and cost and increasing the effectiveness of subsequent on-site visits. The study findings may be useful to industry stakeholders in understanding the early impacts of the use of new remote digital inspection tools on the construction industry.
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