Systematic studies on the GEM foil material are performed to measure the moisture diffusion rate and saturation level. These studies are important because the presence of this compound inside the ...detector’ s foil can possibly change its mechanical and electrical properties, and in such a way, the detector performance can be affected. To understand this phenomenon, a model is developed with COMSOL Multiphysics v. 4.3 1, which described the adsorption and diffusion within the geometry of GEM foil, the concentration profiles and the time required to saturate the foil. The COMSOL model is verified by experimental observations on a GEM foil sample. This note will describe the model and its experimental verification results.
The Italian white truffle (Tuber magnatum Pico) forms mycorrhizal relationships, with the roots of, for example, poplars, willows, oaks, aspen, alder and hazelnut in Northern Italy and in small areas ...of Southern France, Switzerland and Yugoslavia. Its fruiting bodies, which are harvested in autumn and early winter, have a strong aroma and taste and are much sought-after by chefs and gourmets. Because they do not preserve well, good quality Italian white truffle is unavailable for much of the year. The vegetation, climate and soils where T. magnatum grows in Italy are described and compared with those found in similar areas in New Zealand. Market information and methods for cultivating T. magnatum are also presented. /// La trufa blanca italiana (Tuber magnatum Pico) forma una relación micorrízica con las raíces de, entre otros, álamos, sauces, robles, aspen and poplar are the same genus, Populus, which is álamo in Spanish, or more rarely temblón, so possibly not worth writing down separately, alisos y avellanas en el norte de Italia y pequeñas áreas del sur de Francia, Suiza y Yugoslavia. Sus cuerpos fructíferos, cosechados en otoño y principios del invierno, tienen fuerte aroma y sabor y son muy buscados por chefs y gourmets. Debido a que no se conserva bien, la trufa blanca italiana de buena calidad no se consigue durante gran parte del año. Se describen la vegetación, clima y suelos donde crece T. magnatum en Italia y se comparan con aquellos de áreas similares de Nueva Zelandia. También se presenta información de mercado y métodos para cultivar T. magnatum.
The spatial variability of microbial biomass C and three humification indexes (the degree of humification, DH; the index of humification, HI; and the humification rate, HR) were investigated in order ...to evaluate their usefulness as indicators of the response of soil organic matter to altered soil environments. The investigation was carried out by examining the topsoil layer of an experimental field characterized by the presence of four phases of one soil series and, except for the addition of cattle manure in part of the field, by fairly uniform agricultural practices. A rectangular area of 350 by 800 m was sampled on a square grid scheme coupled with nesting. The experimental objective was to determine if the investigated properties were influenced by changes in soil type and by the addition of cattle manure. All properties measured showed spatial dependence at the sampling distances adopted. Two groups of properties were identified based on their degree of spatial variability: microbial biomass C, DH, and HI exhibited short-range variability, whereas HR varied across longer distances. Microbial biomass C and HR showed a spatial pattern related to soil amendment and soil types, respectively. Therefore, these variables provided complementary information about the condition of soil organic matter in the study area
Osimertinib is an irreversible tyrosine kinase inhibitor approved for the treatment of metastatic epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). In clinical ...trials, osimertinib has exhibited excellent activity and less toxicity compared to gefitinib, erlotinib and standard chemotherapy.
Herein, we describe the case of a 69-year-old man who received first-line osimertinib for metastatic EGFR-mutated NSCLC. Suspected osimertinib-induced pancytopenia together with a partial treatment response was assessed after 10 days of therapy. Osimertinib was resumed at 40 mg daily a month later while the patient exhibited durable stable disease. No other adverse events occurred.
In the current case, first-line treatment with osimertinib at 80 mg daily in a patient with EGFR-mutated NSCLC resulted in severe pancytopenia and a rapid treatment response. Dose reduction to 40 mg daily resulted in excellent activity without any further adverse events. Osimertinib could be safely resumed at a reduced dose even after pancytopenia.
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