Endowing a single material with various types of luminescence, that is, exhibiting a simultaneous optical response to different stimuli, is vital in various fields. A photoluminescence (PL)- and ...mechanoluminescence (ML)-based multifunctional sensing platform is built by combining heterojunctioned ZnS/CaZnOS:Mn
mechano-photonic materials using a 3D-printing technique and fiber spinning. ML-active particles are embedded in micrometer-sized cellulose fibers for flexible optical devices capable of emitting light driven by mechanical force. Individually modified 3D-printed hard units that exhibit intense ML in response to mechanical deformation, such as impact and friction, are also fabricated. Importantly, they also allow low-pressure sensing up to ≈100 bar, a range previously inaccessible by any other optical sensing technique. Moreover, the developed optical manometer based on the PL of the materials demonstrates a superior high-pressure sensitivity of ≈6.20 nm GPa
. Using this sensing platform, four modes of temperature detection can be achieved: excitation-band spectral shifts, emission-band spectral shifts, bandwidth broadening, and lifetime shortening. This work supports the possibility of mass production of ML-active mechanical and optoelectronic parts integrated with scientific and industrial tools and apparatus.
Nonlinear optical materials are essential in areas such as nanophotonics, optical information processing, and biomedical imaging. However, nanomaterials employed for these diverse applications to ...date are efficient only for one type of nonlinear optical activity. Herein, the first multimodal nonlinear optically active class of nanomaterials based on lanthanide‐doped lithium niobate nanoparticles, which simultaneously exhibit unprecedentedly efficient second and third harmonic generation, as well as up‐conversion photoluminescence, is reported. These dielectric nanoparticles retain their high nonlinear optical conversion efficiency both as powder and as aqueous colloidal solution. The high stability also allows for the fabrication of optically active biocompatible micron‐sized fibers and polymer‐based 3D‐printable objects, as well as for fingerprint detection. Finally, the first 8‐bit coding platform purely based on multimodal nonlinear optical activity originating from different parametric and nonparametric processes is demonstrated, showcasing the technological potential of these materials for both anti‐counterfeiting and advanced optical information processing.
The present study demonstrates the development of thefirst clananomaterials simultaneously exhibiting multiple efficient nonlinear optical (NLO) processes, nam second harmonic generation, third harmonic generation, and up‐conversion photoluminescence. The synthesized nanoparticles are incorporated in 3D‐printable polymers, fibers, and inks for anti‐counterfeiting, fingerprint detection, biomedical applications, information processing, and thefirst dual‐mode NLO optical coding based on parametric and nonparametric processes.
Abstract
Objectives
The COVID-19 outbreak has worsened the ongoing economic crisis in Puerto Rico by creating “parallel pandemics” that exacerbate socioeconomic and health inequalities experienced by ...its most vulnerable residents. Unfortunately, conditions on the island have been largely overlooked by national media outlets and the mainland U.S. population. Thus, this research report aims to draw attention to the disparate burden multiple and compounding disasters have on older island-dwelling Puerto Rican adults’ health and well-being.
Methods
We characterize the lived experiences of the older population in Puerto Rico by incorporating data from multiple sources and contextualizing the effects of compounding disasters, the fiscal pandemic, and health care challenges to provide a more nuanced portrait of existing compounding factors that negatively affect the health and well-being of older adults in the era of COVID-19.
Results
We highlight 2 main factors that exacerbate pre-pandemic inequities experienced by the older adult population amid the COVID-19 pandemic in Puerto Rico: (a) the impact of multiple and compounding disasters; and (b) health care challenges.
Discussion
The human suffering of the Puerto Rican population is compounded by the consequences of fiscal austerity, increasing levels of income and wealth inequality, the debt crisis, significant emigration, and a dysfunctional health care system. Future governmental actions are required to lessen the burden of parallel pandemics on older adults in Puerto Rico.
This study investigated the post-activation performance enhancements (PAPE) induced by a high-intensity single set of accentuated eccentric isoinertial resistance exercise on vertical jump ...performance. Twenty physically active male university students performed, in randomized counterbalanced order, two different conditioning activities (CA) after a general preestablished warm-up: a conditioning set of 6 maximum repetitions at high intensity (i.e., individualized optimal moment of inertia 0.083 ± 0.03 kg·m
) of the flywheel half-squat exercise in the experimental condition, or a set of 6 maximal countermovement jumps (CMJ) instead of the flywheel exercise in the control condition. CMJ height, CMJ concentric peak power and CMJ concentric peak velocity were assessed at baseline (i.e., 3 minutes after the warm-up) and 4, 8, 12, 16 and 20 minutes after the CA in both experimental and control protocols. Only after the experimental protocol were significant gains in vertical jump performance (p < 0.05, ES range 0.10-1.34) at 4, 8, 12, 16 and 20 minutes after the CA observed. In fact, the experimental protocol showed greater (p < 0.05) CMJ height, concentric peak power and concentric peak velocity enhancements compared to the control condition. In conclusion, a single set of high-intensity flywheel training led to PAPE in CMJ performance after 4, 8, 12, 16 and 20 minutes in physically active young men.
The aim of this study was to examine the validity and reliability of an Inertial Measurement System integrated into a secondary pulley (IMS) for determining linear velocity during flywheel squat ...exercises. Thirty-one male participants who were highly experienced in a flywheel resistance exercise training performed flywheel squat exercises with three incremental loads, and mean velocity (MV), mean propulsive velocity (MPV) and max velocity (Vmax) of the exercises were simultaneously recorded with a validated linear encoder and the IMS, in two different sessions. Validity was analyzed using ordinary least products regression (OLP), Lin's concordance correlation coefficient (CCC), and Hedge's g for the values from the linear encoder and the IMS. Test-retest reliability was determined by coefficient of variation (CV), Intraclass correlation coefficient (ICC), and standard error of measurement (SEM). Results showed a high degree of validity (OLP intercept = -0.09-0.00, OLP slope = 0.95-1.04, CCC = 0.96-0.99, Hedge's g < 0.192, SEM = 0.04-0.08) and reliability (CV < 0.21%, ICC > 0.88, SEM < 0.08). These results confirm that the IMS provides valid and reliable measures of movement velocity during flywheel squat exercises.
PURPOSE Three-year disease-free survival (DFS) was significantly improved in patients who had undergone resection with curative intent for stage II or III colon cancer who received bolus plus ...continuous-infusion fluorouracil plus leucovorin (LV5FU2) with the addition of oxaliplatin (FOLFOX4). Final results of the study, including 6-year overall survival (OS) and 5-year updated DFS, are reported. PATIENTS AND METHODS A total of 2,246 patients were randomly assigned to receive LV5FU2 or FOLFOX4 for 6 months. The primary end point was DFS. Secondary end points were OS and safety. Results Five-year DFS rates were 73.3% and 67.4% in the FOLFOX4 and LV5FU2 groups, respectively (hazard ratio HR = 0.80; 95% CI, 0.68 to 0.93; P = .003). Six-year OS rates were 78.5% and 76.0% in the FOLFOX4 and LV5FU2 groups, respectively (HR = 0.84; 95% CI, 0.71 to 1.00; P = .046); corresponding 6-year OS rates for patients with stage III disease were 72.9% and 68.7%, respectively (HR = 0.80; 95% CI, 0.65 to 0.97; P = .023). No difference in OS was seen in the stage II population. The incidence of second noncolorectal cancers was 5.5% and 6.1% in the FOLFOX4 and LV5FU2 groups, respectively. Among patients receiving oxaliplatin, the frequency of grade 3 peripheral sensory neuropathy was 1.3% 12 months after treatment and 0.7% at 48 months. CONCLUSION Adding oxaliplatin to LV5FU2 significantly improved 5-year DFS and 6-year OS in the adjuvant treatment of stage II or III colon cancer and should be considered after surgery for patients with stage III disease.
Purpose:
To propose the concentric linear velocity measurement as a valid method to quantify load and individualise the prescription of flywheel training, we investigated the relationship between ...inertial load and mean concentric linear velocity (MCLV) during the flywheel squat exercise in a wide spectrum of intensities. In addition, we compared MCLV and subjective rating of perceived exertion (RPE) after each load.
Methods:
Twenty-five physically active men volunteered for this study (26.5 ± 2.9 years, 179.5 ± 4.2 cm, 81.6 ± 8.6 kg). After familiarization, all participants performed two inertial progressive load tests on separated days to determine the flywheel load-velocity profile and its reliability. Each participant performed 5 set of 6 repetitions of the flywheel squat exercise with different inertial loads (0.047, 0.104, 0.161, 0.245, 0.321 kg m
2
) selected in a counterbalanced and randomized order for each testing day. Average MCLV and RPE for each load were compared.
Results:
The inter-session intraclass correlation coefficient (ICC) showed values above 0.9 in all the included outcomes (MCLV: ICC = 0.91; RPE: ICC = 0.93). A significant correlation (
p
< 0.01,
R
2
= 0.80) between inertial load and MCLV was found. Similarly, significant correlation models (
p
< 0.01) were observed between RPE and load (
R
2
= 0.87) and (
R
2
= 0.71) between RPE and MCLV.
Conclusion:
The control of MCLV during flywheel exercise can be proposed as a valid method to quantify load and to individualize the prescription of flywheel training. In addition, RPE responses have demonstrated significant correlations with load and velocity. Therefore, RPE has been proposed as a valid and reliable alternative to control flywheel training.
Panitumumab, a fully human anti-epidermal growth factor receptor (EGFR) monoclonal antibody that improves progression-free survival (PFS), is approved as monotherapy for patients with ...chemotherapy-refractory metastatic colorectal cancer (mCRC). The Panitumumab Randomized Trial in Combination With Chemotherapy for Metastatic Colorectal Cancer to Determine Efficacy (PRIME) was designed to evaluate the efficacy and safety of panitumumab plus infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as initial treatment for mCRC.
In this multicenter, phase III trial, patients with no prior chemotherapy for mCRC, Eastern Cooperative Oncology Group performance status of 0 to 2, and available tissue for biomarker testing were randomly assigned 1:1 to receive panitumumab-FOLFOX4 versus FOLFOX4. The primary end point was PFS; overall survival (OS) was a secondary end point. Results were prospectively analyzed on an intent-to-treat basis by tumor KRAS status.
KRAS results were available for 93% of the 1,183 patients randomly assigned. In the wild-type (WT) KRAS stratum, panitumumab-FOLFOX4 significantly improved PFS compared with FOLFOX4 (median PFS, 9.6 v 8.0 months, respectively; hazard ratio HR, 0.80; 95% CI, 0.66 to 0.97; P = .02). A nonsignificant increase in OS was also observed for panitumumab-FOLFOX4 versus FOLFOX4 (median OS, 23.9 v 19.7 months, respectively; HR, 0.83; 95% CI, 0.67 to 1.02; P = .072). In the mutant KRAS stratum, PFS was significantly reduced in the panitumumab-FOLFOX4 arm versus the FOLFOX4 arm (HR, 1.29; 95% CI, 1.04 to 1.62; P = .02), and median OS was 15.5 months versus 19.3 months, respectively (HR, 1.24; 95% CI, 0.98 to 1.57; P = .068). Adverse event rates were generally comparable across arms with the exception of toxicities known to be associated with anti-EGFR therapy.
This study demonstrated that panitumumab-FOLFOX4 was well tolerated and significantly improved PFS in patients with WT KRAS tumors and underscores the importance of KRAS testing for patients with mCRC.
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