The efficiency of the Data Acquisition (DAQ) of the Compact Muon Solenoid (CMS) experiment for LHC Run 2 is constantly being improved. A significant factor affecting the data taking efficiency is the ...experience of the DAQ operator. One of the main responsibilities of the DAQ operator is to carry out the proper recovery procedure in case of failure of data-taking. At the start of Run 2, understanding the problem and finding the right remedy could take a considerable amount of time (up to many minutes). Operators heavily relied on the support of on-call experts, also outside working hours. Wrong decisions due to time pressure sometimes lead to an additional overhead in recovery time. To increase the efficiency of CMS data-taking we developed a new expert system, the DAQExpert, which provides shifters with optimal recovery suggestions instantly when a failure occurs. DAQExpert is a web application analyzing frequently updating monitoring data from all DAQ components and identifying problems based on expert knowledge expressed in small, independent logic-modules written in Java. Its results are presented in real-time in the control room via a web-based GUI and a sound-system in a form of short description of the current failure, and steps to recover.
GNAQ mutations have been identified in port wine stains (both syndromic and nonsyndromic) and melanocytic ocular neoplasms. This study investigates the presence of GNAQ mutations in diffuse (those ...associated with Sturge-Weber syndrome SWS) and solitary choroidal hemangiomas.
Tissue from 11 patients with the following diagnoses: port wine stain (n = 3), diffuse choroidal hemangioma (n = 1), solitary choroidal hemangioma (n = 6), and choroidal nevus (n = 1).
Ten specimens were interrogated with Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets, a hybridization capture-based next-generation sequencing assay for targeted deep sequencing of all exons and selected introns of 468 key cancer genes in formalin-fixed, paraffin-embedded tumors. Digital polymerase chain reaction was used to detect GNAQ Q209 mutation in 1 specimen.
Detection of GNAQ codon-specific mutation.
Activating somatic GNAQ mutations (c.547C > T; p.Arg183Cys) were found in 100% (3 of 3) of the port wine stain and in the diffuse choroidal hemangioma. Somatic GNAQ mutations (c.626A > T; p.Gln209Leu) were found in 100% (6 of 6) of the solitary choroidal hemangiomas and (c.626A > C; p.Gln209Pro) in the choroidal nevus.
GNAQ mutations occur in both diffuse and solitary hemangiomas, although at distinct codons. An R183 codon is mutant in diffuse choroidal hemangiomas, consistent with other Sturge-Weber vascular malformations. By contrast, solitary choroidal hemangiomas have mutations in the Q209 codon, similar to other intraocular melanocytic neoplasms.
Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, ...including the transverse momenta ( ) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta ( ), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb super(-1). The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the distributions of the leading jets at high values, the distributions of the at high- and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.
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