Objective: We aim to report a systematic review and meta-analysis of randomized controlled trials (RCTs) on effects of olive oil consumption compared with other plant oils on blood lipids.
Methods: ...PubMed, web of science, Scopus, ProQuest, and Embase were systematically searched until September 2017, with no age, language and design restrictions. Weighed mean difference (WMD) and 95% confidence interval (CI) were expressed as effect size. Sensitivity analyses and pre specified subgroup was conducted to evaluate potential heterogeneity. Meta-regression analyses were performed to investigate association between blood lipid-lowering effects of olive oil and duration of treatment.
Results: Twenty-seven trials, comprising 1089 participants met the eligibility criteria. Results of this study showed that compared to other plant oils, high-density lipoprotein level increased significantly more for OO (1.37 mg/dl: 95% CI: 0.4, 2.36). Also OO consumption reduced total cholesterol (TC) (6.27 mg/dl, 95% CI: 2.8, 10.6), Low-density lipoprotein (LDL-c) (4.2 mg/dl, 95% CI: 1.4, 7.01), and triglyceride (TG) (4.31 mg/dl, 95% CI: 0.5, 8.12) significantly less than other plant oils. There were no significant effects on Apo lipoprotein A1 and Apo lipoprotein B.
Conclusion: This meta-analysis suggested that OO consumption decreased serum TC, LDL-c, and TG less but increased HDL-c more than other plant oils.
Limited data exist on the cardiometabolic effects of sesame oil compared with canola oil. In the present study, 77 overweight adults were randomized to replace their regularly consumed oils with ...canola (CO), sesame (SO), and sesame‐canola oils (SCO, 40% SO, and 60% CO) in three 9‐week phases. Blood pressure, visceral adiposity index, serum apo‐proteins (APOs) and lipid profile, glycemic control markers, kidney markers, liver enzymes, and cardiovascular disease risk scores were assessed at baseline and endline. After adjustment for confounders, SO significantly reduced serum alkaline aminotransferase (ALT) compared to CO (p ≤ 0.05) in all participants, increased serum urea compared to SCO in males, and decreased serum alkaline phosphatase compared to other oils in males, and improved serum high‐density lipoprotein cholesterol (HDL‐C) and triglycerides (TG) compared to SCO, and eGFR compared with CO in females (p ≤ 0.05). Canola oil significantly improved serum Apo A1 and APO B/A ratio compared with SO, in males (p ≤ 0.05). Sesame‐canola oil significantly reduced serum urea compared to other oils in all participants (p ≤ 0.05). Sesame oil and SCO might beneficially affect serum ALT and urea, respectively. Intervention oils might have different cardiometabolic effects in each gender. Further studies are needed to confirm our results (Trial registration code: IRCT2016091312571N6).
Background
This study aimed to compare the effects of sesame (SO), canola (CO), and sesame‐canola (SCO: a blend) oils on glycaemic control markers and liver function enzymes in adults with type 2 ...diabetes.
Methods
In this randomized, triple‐blind, three‐way, cross‐over clinical trial, participants replaced their usual oil with the intervention oils for 9 weeks. Serum fasting blood sugar, fasting serum insulin (FSI), insulin resistance (HOMA2‐IR), beta‐cell function (HOMA2‐%B), insulin sensitivity (HOMA2‐%S), quantitative insulin sensitivity check index (QUICKI), as well as serum liver function enzymes were measured at baseline and end of intervention periods.
Results
Ninety‐two participants completed all treatment periods. After adjusting for confounders, all treatment oils resulted in significant improvements in FSI and HOMA2‐%S (p < 0.05). SO and SCO led to favourable changes in HOMA2‐IR and QUICKI (p < 0.05). Following CO and SCO, there was a significant decrease in HOMA2‐%B (p < 0.05). The sex‐stratified analysis revealed that FSI and HOMA2‐IR were decreased after SO compared to CO in males (p = 0.024). Serum gamma‐glutamyltransferase (GGT) was significantly lower following SO compared to CO in females (p = 0.02), however, the difference in change values was not significant (p = 0.058).
Conclusions
SO consumption appears to improve glycaemic control markers in males and serum GGT in females compared with CO in patients with type 2 diabetes (registration code: IRCT2016091312571N6).
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•A number of studies suggested that sesame products improve body weight and composition.•This was the first meta-analysis of the effect of sesame on body weight and composition.•Ten ...controlled clinical trials were eligible to be included in the systematic review.•Sesame supplementation improved body fat percent and body adiposity index.•Sesame oil intake was associated with reduced body weight and body mass index.•Sesame consumption did not affect other indices of body composition.
Previous studies on the effect of sesame products consumption on body weight and composition have led to inconsistent results. Relevant databases were searched up to April 2018 to conduct a systematic review and meta-analysis of controlled clinical trials. Data on body weight, body mass index (BMI), body fat percent, waist circumference (WC), hip circumference (HC), waist to hip ratio (WHR), and body adiposity index (BAI) were extracted. Ten studies were included in the systematic review. Sesame products consumption did not significantly affect body weight and BMI (P > 0.05). Only sesame oil significantly decreased the body weight and BMI (P < 0.05). The body fat percent and the BAI were significantly reduced after sesame consumption (P < 0.05). Sesame consumption did not affect other body composition indices (P > 0.05). The present study provided some evidence regarding the beneficial effects of sesame on body adiposity indices. Further studies are still required to confirm our results. Registration code: CRD42017054149.
We read the review by Arabi et al. with great interest which tried to examine the effects of vitamin D supplementation on hemoglobin concentration. It seems that the article suffers from fundamental ...methodological issues and the conclusions are likely to be erroneous. In this regard, we would like to ask the authors to address the mentioned limitations and to update the analysis in order to provide robust and trustful results. We are concerned that such meta-analyses may lead to the biased findings and conclusions.
Propolis is a sticky, resinous substance produced by honeybees from various plants. Various biological properties of propolis and its extracts have been recognized in previous studies including the ...antiseptic, anti-inflammatory, antioxidant, antiviral, hepatoprotective, antitumor, antibacterial and antimycotic properties. This study aimed to summarize the effect of propolis on metabolic parameters in human adults using systematic review and meta-analysis.
A comprehensive systematic search was performed in ISI Web of Science, PubMed, Scopus, and Google Scholar up to July 2020 for controlled clinical trials evaluating the impact of propolis on lipid profile and liver enzyme biomarkers. A random effects model was used to calculate the weighted mean difference (WMD) and 95% confidence interval (CI) as the difference between the mean for the intervention and control groups.
The present meta-analysis included six randomized controlled trials. There was significant reduction in Aspartate Aminotransferase (AST) in comparison to the control groups (WMD=-2.01; 95% CI: -3.93--0.10; p=0.039). However, a non-significant effect was observed in Triglycerides (TG), Total cholesterol (TC), low-density lipoprotein (LDL), High-density lipoprotein (HDL) (WMD=-0.05 mg/dl; 95% CI: -0.27-0.18; p=0.688; WMD=7.08 mg/dl; 95% CI: -37.31-51.46; p=0.755; WMD=-0.94 mg/dl; 95% CI: -6.64-4.77; p=0.747; WMD=3.14 mg/dl; 95% CI: -1.84-8.13; p=0.216, respectively).
Current meta-analysis revealed that propolis supplementation can reduce AST; nevertheless, there was no significant effect on lipid profile indices and ALT.