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•Four organometallic Ru(II) complexes of 4-oxo-4H-chromene-3-carbaldehyde Schiff base derivatives have been prepared.•CT-DNA and BSA/HSA binding studies were carried out.•MTT assay on ...A549 and MCF-7 cells revealed their anticancer activity.•The complexes were able to inhibit antimicrobial growth in the tested fungal and bacterial species.•Overall, the complex C3 possessed the highest activity with respect to the ligands and other complexes.
Four Ru(II) carbonyl complexes of 4-oxo-4H-chromene-3-carbaldehyde thiosemicarbazones (C1-C4) were synthesized and characterized through spectroscopic techniques. The coordination behaviour of the ligands to the metal ion was confirmed by solving the single crystal X-ray structure of a representative complex C4, in which the ligand showed coordination via the C2 carbon of the chromone ring, the azomethine nitrogen and thiolate sulfur. The interaction with DNA and protein showed a good binding profile of the complexes. Antimicrobial effects of the complexes were tested against bacterial and fungal strains, for which a significant activity was observed. Furthermore, MTT assay on A549 and MCF-7 cell lines indicated the cytotoxic potential of the synthesized complexes, overcoming the cisplatin activity under similar experimental conditions.
A series of 3-acetyl-8-methoxycoumarin appended thiosemicarbazones (1–4) was prepared from the reaction of 3-acetyl-8-methoxycoumarin with 4(N)-substituted thiosemicarbazides in a view of ...ascertaining their biological properties with the change of N-terminal substitution in the thiosemicarbazide moiety. Comprehensive characterization was brought about by various spectral and analytical methods. The molecular structures of all the compounds were determined by single crystal X-ray diffraction analysis. Binding studies with Calf thymus DNA (CT-DNA) and proteins such as Bovine Serum Albumin (BSA) and Human Serum Albumin (HSA) indicated an intercalative mode of binding with DNA and static quenching mechanism with proteins. The compounds cleaved plasmid DNA (pBR322) and acted well as free radical scavengers. A good spectrum of antimicrobial activity was observed against four bacterial and five fungal pathogens. The compounds exhibited profound antiproliferative activity on MCF-7 (human breast cancer) and A549 (human lung carcinoma) cell lines. Assay on human normal keratinocyte cell line HaCaT showed that the compounds were non-toxic to normal cells.
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•8-methoxy-3-acetyl-coumarin derived Schiff bases were synthesized and characterized•DNA/protein interactions of the compounds were studied by a variety of techniques•Antimicrobial activity against bacterial and fungal pathogens have been examined•The compounds showed potent anticancer activity over the standard drug, Cisplatin•Assay on HaCaT cell lines showed that the compounds were non-toxic to those cells.
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•Pyrene saliscylaldehyde conjugate as a fluorescent probe for Al3+ ion.•A PET mechanism has been proposed with a 1:1 binding stoichiometry.•Reversibility of the sensor is proved by ...experiments with EDTA.•Detection and Electrosorptive removal the Al3+ ion in real water samples analyses.•Several biological applications including the bio-imaging of bacterial cells.
A pyrene scaffold bearing a phenol molecule has been designed and synthesized as a chemosensor L1 by an aldol type of condensation reaction. The sensor showed high sensitivity and selectivity for Al3+ ions by the enhancement of fluorescene intensity and distinguishes from the other potentially competing metal ions. The effect of pH, time and the reversibility of the sensor are studied. The fluorescence experiments suggested that the proposed binding of L1 and Al3+ ion is in a 1:1 stoichiometry. The chemosensor’s direct application in the electrosorptive removal of Al3+ ion and several other biological applications including the bio-imaging of bacterial cells were examined.
This study investigated the wound healing properties of the aqueous extract of
Morinda tinctoria
Roxb leaves in rats. The study also provides information on the purification, qualitative, and ...quantitative analysis of phytochemical components present in
M. tinctoria
Roxb. Wound contraction and period of epithelialization was determined and topical application of
M. tinctoria
Roxb aqueous leaf extract showed better healing than orally treated and control groups. The results suggest that the efficacy of
M. tinctoria
Roxb aqueous leaf extract as a wound healing agent and can also be used as a therapeutic agent for internal as well as external wounds.
Nickel ferrite NiFe
2
O
4
nanoparticles (NPs) were successfully synthesized by using nickel nitrate, ferric nitrate, citric acid, and ethyl cellulose as a surfactant by a simple sol–gel-assisted ...combustion method (SACM) and microwave-assisted combustion method (MACM). Structural, morphological, optical, and magnetic properties of the obtained powder were characterized by powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), photoluminescence (PL) spectroscopy, and vibrating sample magnetometry (VSM). XRD results show that the resultant powder was pure crystalline with cubic structure. The average crystalline size was found to be 18.8 and 10.2 nm synthesized by SACM and MACM, respectively. FT-IR spectra indicate the type of bonds between Ni–O and Fe–O (metal and oxygen). SEM images show that the morphology of the powder consists of well-defined structure. VSM results showed a ferromagnetic behavior of the sample. Antimicrobial activity of NiFe
2
O
4
nanoparticles was performed. Both sample 1 (SACM) and sample 2 (MACM) show good inhibition in the zone 100
μ
g/ml. While comparing, sample 2 shows high inhibition than sample 1.
A pyrene scaffold bearing a phenol molecule has been designed and synthesized as a chemosensor L1 by an aldol type of condensation reaction. The sensor showed high sensitivity and selectivity for ...Al3+ ions by the enhancement of fluorescene intensity and distinguishes from the other potentially competing metal ions. The effect of pH, time and the reversibility of the sensor are studied. The fluorescence experiments suggested that the proposed binding of L1 and Al3+ ion is in a 1:1 stoichiometry. The chemosensor’s direct application in the electrosorptive removal of Al3+ ion and several other biological applications including the bio-imaging of bacterial cells were examined.
New cyclometallated ruthenium(
ii
) complexes of 3-acetyl-7-methoxycoumarin-4
N
-substituted thiosemicarbazones were synthesized and characterized by analytical and spectral techniques. The crystal ...structures of the ligands
H
2
L
1-3
and complexes (
1
,
2
and
4
) were confirmed by X-ray crystallography. The analysis showed that the ligands have undergone C-H activation at the C(4) carbon of the pyrone ring and acted in a tridentate fashion by binding through C, N and S atoms. CT-DNA and protein (BSA/HSA) binding studies were carried out to analyze their interaction with biomolecules. Good binding affinity with DNA was observed with intercalative binding mode, which was further confirmed by EB displacement and viscosity measurement studies. The quenching mechanism with BSA/HSA was found to be static. Three dimensional (3D) fluorescence measurements were carried out to validate the micro environmental changes in the serum albumins. Their antioxidant propensity and antimicrobial study insisted that the compounds displayed good spectrum of activity. Evaluation of their anticancer potential against MCF-7 (human breast cancer) and A549 (human lung carcinoma) cell lines revealed that the complexes exhibited better activity than the ligands and cisplatin. Further, the results of LDH and NO release assays supported the cytotoxic nature of the compounds. The non-toxic nature of the compounds was established by testing against the non-cancerous cell line HaCaT (human normal keratinocyte).
New cyclometallated ruthenium(
ii
) complexes of 3-acetyl-7-methoxycoumarin-4
N
-substituted thiosemicarbazones were synthesized and characterized by analytical and spectral techniques.
![3-Acetyl-8-methoxy-2[H]-chr...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/1386-1425/small "3-Acetyl-8-methoxy-2[H]-chromen-2-one derived Schiff bases as potent antiproliferative agents: Insight into the influence of 4(N)-substituents on the in vitro biological activity")
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