Primary Sjögren syndrome (pSS) is a systemic autoimmune disorder that principally affects the exocrine glands but can also affect systemic or extra-glandular sites. Approximately 65-80% of patients ...with Sjogren's demonstrate pulmonary involvement at the CT scan and pulmonary nodules (PNs) can be encountered as a common finding. We present the case of a 49-year-old woman admitted to the emergency department for chest pain and fever. The patient was diagnosed with pSS fourteen years prior and had never taken therapy or followed regular check-ups. At the HRTC were found PNs that were studied trough a CT-PET and a needle biopsy via CT guidance, which showed diffuse large B cell lymphoma. This case report underlies the importance of check-ups and the need for a multidisciplinary approach in the care of Sjögren's syndrome patients.
The potassium channel Kv1.3, involved in several important pathologies, is the target of a family of psoralen-based drugs whose mechanism of action is not fully understood. Here we provide evidence ...for a physical interaction of the mitochondria-located Kv1.3 (mtKv1.3) and Complex I of the respiratory chain and show that this proximity underlies the death-inducing ability of psoralenic Kv1.3 inhibitors. The effects of PAP-1-MHEG (PAP-1, a Kv1.3 inhibitor, with six monomeric ethylene glycol units attached to the phenyl ring of PAP-1), a more soluble novel derivative of PAP-1 and of its various portions on mitochondrial physiology indicate that the psoralenic moiety of PAP-1 bound to mtKv1.3 facilitates the diversion of electrons from Complex I to molecular oxygen. The resulting massive production of toxic Reactive Oxygen Species leads to death of cancer cells expressing Kv1.3. In vivo, PAP-1-MHEG significantly decreased melanoma volume. In summary, PAP-1-MHEG offers insights into the mechanisms of cytotoxicity of this family of compounds and may represent a valuable clinical tool.
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•The mitochondrial channel mitoKv1.3 is a promising pharmacological target.•MitoKv1.3 interacts with Complex I of the respiratory chain.•Psoralenic inhibitors of Kv1.3 facilitate the diversion of e− from complex I to O2.•A novel psoralenic Kv1.3 inhibitor with increased solubility reduces melanoma volume.
In the Northern Volcanic Zone of Iceland, the geometry, kinematics and offset amount of the structures that form the active Krafla Rift were studied. This rift is composed of a central volcano and a ...swarm of extension fractures, normal faults and eruptive fissures, which were mapped and analysed through remote sensing and field techniques. In three areas, across the northern, central and southern part of the rift, detailed measurements were collected by extensive field surveys along the post-Late Glacial Maximum (LGM) extension fractures and normal faults, to reconstruct their strike, opening direction and dilation amount. The geometry and the distribution of all the studied structures suggest a northward propagation of the rift, and an interaction with the Húsavík–Flatey Fault. Although the opening direction at the extension fractures is mostly normal to the general N–S rift orientation (average value N99.5° E), a systematic occurrence of subordinate transcurrent components of motion is noticed. From the measured throw at each normal fault, the heave was calculated, and it was summed together with the net dilation measured at the extension fractures; this has allowed us to assess the stretch ratio of the rift, obtaining a value of 1.003 in the central sector, and 1.001 and 1.002 in the northern and southern part, respectively.
The first wave of the COVID-19 pandemic brought about a broader use of masks by both professionals and the general population. This resulted in a severe worldwide shortage of devices and the need to ...increase import and activate production of safe and effective surgical masks at the national level. In order to support the demand for testing surgical masks in the Italian context, Universities provided their contribution by setting up laboratories for testing mask performance before releasing products into the national market. This paper reports the effort of seven Italian university laboratories who set up facilities for testing face masks during the emergency period of the COVID-19 pandemic. Measurement set-ups were built, adapting the methods specified in the EN 14683:2019+AC. Data on differential pressure (DP) and bacterial filtration efficiency (BFE) of 120 masks, including different materials and designs, were collected over three months. More than 60% of the masks satisfied requirements for DP and BFE set by the standard. Masks made of nonwoven polypropylene with at least three layers (spunbonded-meltblown-spunbonded) showed the best results, ensuring both good breathability and high filtration efficiency. The majority of the masks created with alternative materials and designs did not comply with both standard requirements, resulting in suitability only as community masks. The effective partnering between universities and industries to meet a public need in an emergency context represented a fruitful example of the so-called university "third-mission".
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