Background Shallow, tropical coral reefs face compounding threats from climate change, habitat degradation due to coastal development and pollution, impacts from storms and sea-level rise, and pulse ...disturbances like blast fishing, mining, dredging, and ship groundings that reduce reef height and complexity. One approach toward restoring coral reef physical structure from such impacts is deploying built structures of artificial, natural, or hybrid (both artificial and natural) origin. Built structures range from designed modules and repurposed materials to underwater sculptures and intentionally placed natural rocks. Restoration practitioners and coastal managers increasingly consider incorporating - and in many cases have already begun to incorporate - built structures into coral reef-related applications, yet synthesized evidence on the ecological (coral-related; e.g., coral growth, coral survival) and physical performance of built structures in coral ecosystems across a variety of contexts (e.g., restoration, coastal protection, mitigation, tourism) is not readily available to guide decisions. To help fill this gap and inform management decisions, we systematically mapped the global distribution and abundance of published evidence on the ecological (coral-related) and physical performance of built structure interventions in shallow (less than or equal to 30 m), tropical (35degreesN to 35degreesS) coral ecosystems. Methods To identify potentially relevant articles, we used predefined and tested strategies to search two indexing platforms, one bibliographic database, two open discovery citation indexes, one web-based search engine, one novel literature discovery tool, 19 organizational websites, and information requested from stakeholders. Discovered articles were screened according to preset eligibility criteria first by title and abstract and second by full text. Articles included during full text screening were coded to extract metadata following a predefined framework. We analyzed and visualized the evidence base to answer our primary and secondary research questions and to identify knowledge clusters and gaps. Findings are reported in a narrative synthesis. Results Our search discovered > 20,000 potentially relevant unique articles, of which 258 were included in the systematic map. The evidence base spans 50 countries, and the volume of evidence increased over the past five decades. Built structures were most commonly installed for coral restoration (61%) or coastal protection (12%). Structures were predominately characterized as artificial (87%), with fewer hybrid or natural interventions. Evidence clusters existed for intentionally designed artificial structures and outcomes associated with coral-related ecological performance, including coral mortality, growth, recruitment, cover, and diversity. Pronounced evidence gaps occurred at the intersection of several ecological coral-related performance outcomes (e.g., connectivity, microbiome) across all types of built structures; gaps also existed across most ecological coral-related outcomes for artwork and repurposed artificial structures. Physical performance of built structures was most frequently evaluated for outcomes related to waves (n = 14) and sediment and morphology (n = 11) with pervasive evidence gaps across other outcomes like storm surge and water level. Conclusions While the systematic map highlighted several evidence clusters, it also revealed pronounced evidence gaps surrounding the coral-related ecological and physical performance of built structures in coral ecosystems. The compiled evidence base will help inform policy, management, and future consideration of built structures in reef-related applications, including habitat restoration, environmental mitigation, and coastal protection. Map findings also point to promising future research avenues, such as investigating seascape-scale ecological effects of and the physical performance of built structures. Keywords: Artificial structures, Designed habitat, Coastal protection, Coastal restoration, Coastal mitigation, Eco-engineering, Natural infrastructure, Nature-based solutions, Nature-inspired designs
To report a rare case of endogenous endophthalmitis caused by Staphylococcus capitis.
A 34-year-old male patient with a history of gonococcal urethritis and arthritis presented with right endogenous ...endophthalmitis. Vitreous biopsy culture confirmed Staphylococcus capitis involvement. The patient was treated with pars plana vitrectomy, intravitreal vancomycin, and ceftazidime injections and systemic antibiotics.
Staphylococcus capitis-related endogenous endophthalmitis has rarely been reported in the literature. None of the published reports specifically describe its clinical course and management.
Objective: The proximal tibia is a recommended and commonly used site for pediatric emergency intraosseous vascular access (IO). During forensic whole body postmortem computed tomography (PMCT), we ...evaluated accuracy of emergency placement of tibial IO access.
Methods: We conducted a retrospective review of 92 state medical examiner cases to assess presence and placement of tibial IO needles. Insertions were classified as successful (needle tip in the medullary portion of the bone) or unsuccessful (all other non-medullary placements) based upon position of the needle tip. Medical records were reviewed for patient age, equipment, and where an insertion was attempted, as well as if IO placement occurred in a prehospital or hospital environment.
Results: Thirty-one cases with 42 tibial devices (aged 3 weeks to 16 years, median 4 months) were identified. In 25 insertions (60%), the needle tip was in satisfactory position. In 17 placements (40%), needle tip was unsatisfactory and included tibia perforation (6), tip embedded in the cortex (6), and needle missed the bone (5). In patients older than 6 months, all six placements of a 15-mm needle were successful. In infants age 6 months or younger, 14 placements (56%) were successful and 11 (44%) unsuccessful. The 25-mm IO needle was successfully placed in five of six children older than 6 months. In infants age 6 months or younger, the 25-mm needle was unsuccessfully placed in five of five attempts.
Conclusion: In infants 6 months of age or younger, tibial IO needle insertion had a 53% failure rate (non-medullary placement). Failures occur during both prehospital and emergency department care. In infants age 6 months or younger, use of a 25-mm needle should be avoided. Procedures for IO insertion in infants age 6 months or younger should be reviewed and modification considered.
Background
Most American adolescents have access to smartphones, and recent estimates suggest that they spend considerable time on social media compared with other physical and leisure activities. A ...large body of literature has established that social media use is related to poor mental health, but the complicated relationship between social media and symptoms of depression and anxiety in adolescents is yet to be fully understood.
Objective
We aim to investigate the relationship between social media use and depression and anxiety symptoms in adolescents by exploring physical activity as a mediator.
Methods
A Qualtrics survey manager recruited adult panel participants between February and March 2019, who indicated that they had adolescent children who spoke English. A total of 4592 adolescent-parent dyads completed the survey that took approximately 39 minutes. The survey entailed completing web-based questionnaires assessing various aspects of social media use, psychological symptoms, and psychosocial factors. The average age of the adolescent participants was 14.62 (SD 1.68; range 12-17) years, and the majority of the adolescent sample was male (2392/4592, 52.09%).
Results
Total social media use was associated with more depressive symptoms (multiple R2=0.12; F3,4480=207.1; P<.001), anxiety (multiple R2=0.09; F3,4477=145.6; P<.001), and loneliness (multiple R2=0.06; F3,4512=98.06; P<.001), controlling for age and gender. Physical activity was associated with decreased depression and anxiety symptoms after controlling for other extracurricular activities and social media use (multiple R2=0.24; F5,4290=266.0; P<.001). There were significant differences in symptoms based on gender: female adolescents reported higher rates of social media use and males reported higher rates of depression. Nonbinary and transgender adolescents had higher rates of depression, anxiety, and loneliness than the female and male adolescents in the sample.
Conclusions
In a nationally representative sample of adolescents, more social media use was associated with more severe symptoms of depression, anxiety, and loneliness. Increased physical activity was associated with decreased depression and anxiety symptoms. Physical activity partially mediated the relationship between social media use and depression and anxiety. As this was a cross-sectional study, we cannot conclude that social media use causes internalizing symptoms or that physical activity leads to decreased internalizing symptoms—there may be additional confounding variables producing the relationships we observed. Physical activity may protect against the potentially harmful effect of social media on some adolescents. The effect sizes were small to medium, and the results should be interpreted with caution. Other limitations of this study include our reliance on self-reporting. Future work should examine social media use beyond how much time adolescents spend using social media and instead focus on the nature of social media activity.
We performed orthogonal technology comparisons of concurrent peripheral blood and biopsy tissue samples from 69 kidney transplant recipients who underwent comprehensive algorithm‐driven clinical ...phenotyping. The sample cohort included patients with normal protocol biopsies and stable transplant (sTx) function (n = 25), subclinical acute rejection (subAR, n = 23), and clinical acute rejection (cAR, n = 21). Comparisons between microarray and RNA sequencing (RNA‐seq) signatures were performed and demonstrated a strong correlation between the blood and tissue compartments for both technology platforms. A number of shared differentially expressed genes and pathways between subAR and cAR in both platforms strongly suggest that these two clinical phenotypes form a continuum of alloimmune activation. SubAR is associated with fewer or less expressed genes than cAR in blood, whereas in biopsy tissues, this clinical phenotype demonstrates a more robust molecular signature for both platforms. The discovery work done in this study confirms a clear ability to detect gene expression profiles for sTx, subAR, and cAR in both blood and biopsy tissue, yielding equivalent predictive performance that is agnostic to both technology and platform. Our data also provide strong biological insights into the molecular mechanisms underlying these signatures, underscoring their logistical potential as molecular diagnostics to improve clinical outcomes following kidney transplantation.
Using orthogonal microarray and next‐generation sequencing technologies, the authors demonstrate the ability to discover and internally validate gene expression profiles for two clinical phenotypes.
Pulsating aurora, which consists of diffuse patches blinking on and off, is caused by pitch angle scattering of radiation belt electrons into the loss cone by lower-band chorus waves. Understanding ...the drivers of pulsating aurora is important as it is a long-lasting and widespread phenomenon, accounting for significant energy transfer from the solar wind into the ionosphere. Substorm injections, which transport electrons from the magnetotail into the inner magnetosphere, are one source of electrons in this region. Injections have been observed simultaneously with pulsating aurora during conjunctions between ground cameras and satellites. In addition, previous work has also shown that substorms can enhance chorus activity (the fundamental process that produces pulsating aurora), providing a mechanism linking substorms to pulsating aurora. To further study this connection, we used the Van Allen Probes and all-sky cameras to look at events where pulsating aurora and substorm injections were observed at different locations in Magnetic Local Time (MLT), rather than focusing only on conjunctions. To make this comparison, we calculated the drift rate of electrons originating from observed injections and projected their motion forward in time until their Magnetic Local Time was the same as the ground camera. When the electrons are located at the same MLT as the ground camera, the pulsating aurora they cause would most likely occur in the field of view of the camera. We compared the time drifting substorm-injected particles arrived at the MLT of the camera to when pulsating aurora was observed. We found several instances where the initiation or intensification of pulsating aurora was accompanied by the arrival of substorm-injected electrons. This observation gives further evidence that pulsating aurora can be enhanced by or occur after substorm injections.
The guanine-to-adenine substitution at nucleotide 1606 (G1606A) mutation in the mitochondrial DNA transfer RNA-valine gene has been reported to cause sensorineural deafness, ataxia, myoclonus, ...seizures, and mental retardation. This study hereby presents a single case report of a new retinal phenotype associated with this mutation: a middle-aged woman with retinal pigment epithelium stippling, atrophy, and peripapillary (retinal pigment epithelium) dropout on fundus examination. The patient was administered an empiric trial of a mitochondrial cocktail with close monitoring of her systemic symptoms. This study identified a novel G1606A mutation to cause early-onset macular pathology resembling that previously described in the A3243G mutation.
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Reducing prejudice in childhood requires changing group norms that often perpetuate prejudicial attitudes and in-group bias. Research has shown that intergroup contact is one of the most effective ...means to reduce prejudice. Yet little research has examined whether intergroup contact in the form of class discussions that challenge negative group norms might promote the desire to play with diverse peers. This study tested whether a classroom intervention program, Developing Inclusive Youth, which included experiences of direct and indirect contact, would increase children’s desire for contact with diverse peers and reduce reported experiences of social exclusion. A multisite randomized control trial was implemented with 983 students (502 females; 58.5% White; M age = 9.64 years) and 48 teachers in 48 third-, fourth-, and fifth-grade classrooms across six schools. Overall, students in the program displayed more positive expectations about play with diverse peers and fewer experiences with social exclusion. Classroom discussions involved challenging group norms that perpetuate same-group preferences. Children’s grade moderated their desire for contact with peers from some but not all social groups. This type of program may be an effective means for increasing positive, inclusive group norms in childhood, as this is a time in development when attitudes and preferences for peer friendships are forming. Increasing positive intergroup norms in the classroom creates academic learning environments that promote healthy child development. (PsycInfo Database Record (c) 2024 APA, all rights reserved) (Source: journal abstract)
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