We present a new determination of the ultraviolet (UV) galaxy luminosity function (LF) at redshift z 7 and 8, and a first estimate at z 9. An accurate determination of the form and evolution of the ...galaxy LF during this era is of key importance for improving our knowledge of the earliest phases of galaxy evolution and the process of cosmic reionization. Our analysis exploits to the full the new, deepest Wide Field Camera 3/infrared imaging from our Hubble Space Telescope (HST) Ultra-Deep Field 2012 (UDF12) campaign, with dynamic range provided by including a new and consistent analysis of all appropriate, shallower/wider area HST survey data. Our new measurement of the evolving LF at z 7 to 8 is based on a final catalogue of 600 galaxies, and involves a step-wise maximum-likelihood determination based on the photometric redshift probability distribution for each object; this approach makes full use of the 11-band imaging now available in the Hubble Ultra-Deep Field (HUDF), including the new UDF12 F140W data, and the latest Spitzer IRAC imaging. The final result is a determination of the z 7 LF extending down to UV absolute magnitudes M
1500 = −16.75 (AB mag) and the z 8 LF down to M
1500 = −17.00. Fitting a Schechter function, we find M1500
* = −19.90+0.23
−0.28, log φ* = −2.96+0.18
−0.23 and a faint-end slope α = −1.90+0.14
−0.15 at z 7, and M1500* = −20.12+0.37
−0.48, log φ* = −3.35+0.28
−0.47 and α = −2.02+0.22
+0.23 at z 8. These results strengthen previous suggestions that the evolution at z > 7 appears more akin to 'density evolution' than the apparent 'luminosity evolution' seen at z 5 − 7. We also provide the first meaningful information on the LF at z 9, explore alternative extrapolations to higher redshifts, and consider the implications for the early evolution of UV luminosity density. Finally, we provide catalogues (including derived z
phot, M
1500 and photometry) for the most robust z ∼ 6.5-11.9 galaxies used in this analysis. We briefly discuss our results in the context of earlier work and the results derived from an independent analysis of the UDF12 data based on colour-colour selection.
We present the results of a new search for galaxies at redshift z ≃ 9 in the first two Hubble Frontier Fields with completed HST WFC3/IR and ACS imaging. To ensure robust photometric redshift ...solutions, and to minimize incompleteness, we confine our search to objects with H
160 < 28.6 (AB mag), consider only image regions with an rms noise σ160 > 30 mag (within a 0.5-arcsec diameter aperture), and insist on detections in both H
160 and J
140. The result is a survey covering an effective area (after accounting for magnification) of 10.9 arcmin2, which yields 12 galaxies at 8.4 < z < 9.5. Within the Abell-2744 cluster and parallel fields, we confirm the three brightest objects reported by Ishigaki et al., but recover only one of the four z > 8.4 sources reported by Zheng et al. In the MACSJ0416.1−240 cluster field, we report five objects, and explain why each of these eluded detection or classification as z ≃ 9 galaxies in the published searches of the shallower CLASH data. Finally, we uncover four z ≃ 9 galaxies from the MACSJ0416.1−240 parallel field. Based on the published magnification maps, we find that only one of these 12 galaxies is likely boosted by more than a factor of 2 by gravitational lensing. Consequently, we are able to perform a fairly straightforward reanalysis of the normalization of the z ≃ 9 UV galaxy luminosity function as explored previously in the HUDF12 programme. We conclude that the new data strengthen the evidence for a continued smooth decline in UV luminosity density (and hence star formation rate density) from z ≃ 8 to 9, contrary to recent reports of a marked drop-off at these redshifts. This provides further support for the scenario in which early galaxy evolution is sufficiently extended to explain cosmic reionization.
We use the new ultra-deep, near-infrared imaging of the Hubble Ultra-Deep Field (HUDF) provided by our UDF12 Hubble Space Telescope (HST) Wide Field Camera 3/IR campaign to explore the rest-frame ...ultraviolet (UV) properties of galaxies at redshifts z > 6.5. We present the first unbiased measurement of the average UV power-law index, 〈β〉, (f
λ ∝ λβ) for faint galaxies at z 7, the first meaningful measurements of 〈β〉 at z 8, and tentative estimates for a new sample of galaxies at z 9. Utilizing galaxy selection in the new F140W (J
140) imaging to minimize colour bias, and applying both colour and power-law estimators of β, we find 〈β〉 = −2.1 ± 0.2 at z 7 for galaxies with M
UV −18. This means that the faintest galaxies uncovered at this epoch have, on average, UV colours no more extreme than those displayed by the bluest star-forming galaxies at low redshift. At z 8 we find a similar value, 〈β〉 = −1.9 ± 0.3. At z 9, we find 〈β〉 = −1.8 ± 0.6, essentially unchanged from z 6 to 7 (albeit highly uncertain). Finally, we show that there is as yet no evidence for a significant intrinsic scatter in β within our new, robust z 7 galaxy sample. Our results are most easily explained by a population of steadily star-forming galaxies with either solar metallicity and zero dust, or moderately sub-solar ( 10-20 per cent) metallicity with modest dust obscuration (A
V
0.1-0.2). This latter interpretation is consistent with the predictions of a state-of-the-art galaxy-formation simulation, which also suggests that a significant population of very-low metallicity, dust-free galaxies with β −2.5 may not emerge until M
UV > −16, a regime likely to remain inaccessible until the James Webb Space Telescope.
We present the results of a study investigating the sizes and morphologies of redshift 4 < z < 8 galaxies in the CANDELS (Cosmic Assembly Near-infrared Deep Extragalactic Legacy Survey) GOODS-S ...(Great Observatories Origins Deep Survey southern field), HUDF (Hubble Ultra-Deep Field) and HUDF parallel fields. Based on non-parametric measurements and incorporating a careful treatment of measurement biases, we quantify the typical size of galaxies at each redshift as the peak of the lognormal size distribution, rather than the arithmetic mean size. Parametrizing the evolution of galaxy half-light radius as r
50 ∝ (1 + z)
n
, we find n = −0.20 ± 0.26 at bright UV-luminosities (0.3L
*(z = 3) < L < L
*) and n = −0.47 ± 0.62 at faint luminosities (0.12L
* < L < 0.3L
*). Furthermore, simulations based on artificially redshifting our z ∼ 4 galaxy sample show that we cannot reject the null hypothesis of no size evolution. We show that this result is caused by a combination of the size-dependent completeness of high-redshift galaxy samples and the underestimation of the sizes of the largest galaxies at a given epoch. To explore the evolution of galaxy morphology we first compare asymmetry measurements to those from a large sample of simulated single Sérsic profiles, in order to robustly categorize galaxies as either ‘smooth’ or ‘disturbed’. Comparing the disturbed fraction amongst bright (M
1500 ≤ −20) galaxies at each redshift to that obtained by artificially redshifting our z ∼ 4 galaxy sample, while carefully matching the size and UV-luminosity distributions, we find no clear evidence for evolution in galaxy morphology over the redshift interval 4 < z < 8. Therefore, based on our results, a bright (M
1500 ≤ −20) galaxy at z ∼ 6 is no more likely to be measured as ‘disturbed’ than a comparable galaxy at z ∼ 4, given the current observational constraints.
ABSTRACT
We discuss the spectral energy distributions and physical properties of six galaxies whose photometric redshifts suggest they lie beyond a redshift z ≃ 9. Each was selected on account of a ...prominent excess seen in the Spitzer/IRAC 4.5 $\mu$m band which, for a redshift above z = 9.0, likely indicates the presence of a rest-frame Balmer break and a stellar component that formed earlier than a redshift z ≃ 10. In addition to constraining the earlier star formation activity on the basis of fits using stellar population models with BAGPIPES, we have undertaken the necessary, but challenging, follow-up spectroscopy for each candidate using various combinations of Keck/MOSFIRE, VLT/X-shooter, Gemini/FLAMINGOS2, and ALMA. Based on either Lyman-α or O iii 88 $\mu$m emission, we determine a convincing redshift of z = 8.78 for GN-z-10-3 and a likely redshift of z = 9.28 for the lensed galaxy MACS0416-JD. For GN-z9-1, we conclude the case remains promising for a source beyond z ≃ 9. Together with earlier spectroscopic data for MACS1149-JD1, our analysis of this enlarged sample provides further support for a cosmic star formation history extending beyond redshifts z ≃ 10. We use our best-fitting stellar population models to reconstruct the past rest-frame UV luminosities of our sources and discuss the implications for tracing earlier progenitors of such systems with the James Webb Space Telescope.
Despite treatment with therapeutic hypothermia, almost 50% of infants with neonatal encephalopathy still have adverse outcomes. Additional treatments are required to maximize neuroprotection. ...Melatonin is a naturally occurring hormone involved in physiological processes that also has neuroprotective actions against hypoxic-ischaemic brain injury in animal models. The objective of this study was to assess neuroprotective effects of combining melatonin with therapeutic hypothermia after transient hypoxia-ischaemia in a piglet model of perinatal asphyxia using clinically relevant magnetic resonance spectroscopy biomarkers supported by immunohistochemistry. After a quantified global hypoxic-ischaemic insult, 17 newborn piglets were randomized to the following: (i) therapeutic hypothermia (33.5°C from 2 to 26 h after resuscitation, n = 8) and (ii) therapeutic hypothermia plus intravenous melatonin (5 mg/kg/h over 6 h started at 10 min after resuscitation and repeated at 24 h, n = 9). Cortical white matter and deep grey matter voxel proton and whole brain (31)P magnetic resonance spectroscopy were acquired before and during hypoxia-ischaemia, at 24 and 48 h after resuscitation. There was no difference in baseline variables, insult severity or any physiological or biochemical measure, including mean arterial blood pressure and inotrope use during the 48 h after hypoxia-ischaemia. Plasma levels of melatonin were 10 000 times higher in the hypothermia plus melatonin than hypothermia alone group. Melatonin-augmented hypothermia significantly reduced the hypoxic-ischaemic-induced increase in the area under the curve for proton magnetic resonance spectroscopy lactate/N-acetyl aspartate and lactate/total creatine ratios in the deep grey matter. Melatonin-augmented hypothermia increased levels of whole brain (31)P magnetic resonance spectroscopy nucleotide triphosphate/exchangeable phosphate pool. Correlating with improved cerebral energy metabolism, TUNEL-positive nuclei were reduced in the hypothermia plus melatonin group compared with hypothermia alone in the thalamus, internal capsule, putamen and caudate, and there was reduced cleaved caspase 3 in the thalamus. Although total numbers of microglia were not decreased in grey or white matter, expression of the prototypical cytotoxic microglial activation marker CD86 was decreased in the cortex at 48 h after hypoxia-ischaemia. The safety and improved neuroprotection with a combination of melatonin with cooling support phase II clinical trials in infants with moderate and severe neonatal encephalopathy.
Multimodal measurements combining broadband near-infrared spectroscopy (NIRS) and phosphorus magnetic resonance spectroscopy (31P MRS) assessed associations between changes in the oxidation state of ...cerebral mitochondrial cytochrome-c-oxidase (ΔoxCCO) and 31P metabolite peak-area ratios during and after transient cerebral hypoxia–ischemia (HI) in the newborn piglet.
Twenty-four piglets (aged<24h) underwent transient HI (inspired oxygen fraction 9% and bilateral carotid artery occlusion for ~20min). Whole-brain 31P MRS and NIRS data were acquired every minute. Inorganic phosphate (Pi)/epp, phosphocreatine (PCr)/epp, and total nucleotide triphosphate (NTP)/epp were measured by 31P MRS and were plotted against ΔoxCCO during HI and recovery (epp=exchangeable phosphate pool=Pi+PCr+2γ-NTP+β-NTP).
During HI ΔoxCCO, PCr/epp and NTP/epp declined and Pi/epp increased. Significant correlations were seen between 31P ratios and ΔoxCCO; during HI a threshold point was identified where the relationship between ΔoxCCO and both NTP/epp and Pi/epp changed significantly. Outcome at 48h related to recovery of ΔoxCCO and 31P ratios 1h post-HI (survived: 1-h NTP/epp 0.22±0.02, ΔoxCCO −0.29±0.50μM; died: 1-h NTP/epp 0.10±0.04, ΔoxCCO −2.41±1.48μM).
Both lowered ΔoxCCO and NTP/epp 1h post-HI indicated mitochondrial impairment. Animals dying before 48h had slower recovery of both ΔoxCCO and 31P ratios by 1h after HI.
•31P MRS correlated with broadband NIRS during and after transient hypoxia–ischemia.•A double-linear model best describes NTP/epp vs ΔoxCCO during HI.•Threshold point in double-linear model interpreted as cessation of ATP manufacture.•Poor outcome correlates with weaker recovery of both 31P MRS ratios and ΔoxCCO.•Mitochondrial dysfunction may be the cause of reduction of ΔoxCCO.
Following the discovery of the first significant samples of galaxies at z > 6.5 with Wide Field Camera 3/Infra-Red (WFC3/IR) on board Hubble Space Telescope (HST), it has been claimed that the ...faintest high-redshift galaxies display extremely blue ultraviolet (UV) continuum slopes, with a UV power-law index β≃−3 (where f
λ∝λβ). Such slopes are bluer than previously reported for any other galaxy population, and are most readily explained theoretically by extinction-free, young and very low metallicity stellar populations with a high ionizing photon escape fraction. Here we undertake a critical study of the evidence for such extreme values of β, combining three new WFC3/IR-selected samples of galaxies spanning nearly two decades in UV luminosity over the redshift range z≃ 4.5-8. We explore the impact of inclusion/exclusion of less robust high-redshift candidates and use the varying depths of the samples to explore the effects of noise and selection bias at a given UV luminosity. Simple data-consistency arguments suggest that artificially blue average values of β can result when the analysis is extended into the deepest ≃0.5 mag bin of these WFC3/IR-selected galaxy samples, regardless of the actual luminosity or redshift range probed. By confining attention to robust high-redshift galaxy candidates, with at least one 8σ detection in the WFC3/IR imaging, we find that the average value of β is consistent with 〈β〉=−2.05 ± 0.10 over the redshift range z= 5-7 and the UV absolute magnitude range −22 < M
UV,AB < − 18, and that 〈β〉 shows no significant trend with either redshift or M
UV. We create and analyse a set of simple end-to-end simulations based on the WFC3/IR+ACS Hubble Ultra Deep Field (HUDF) and Early Release Science data sets which demonstrate that a bias towards artificially low/blue average values of β is indeed 'expected' when the UV slope analysis is extended towards the source detection threshold, and conclude that there is as yet no clear evidence for UV slopes significantly bluer than β≃−2, the typical value displayed by the bluest star-forming galaxies at more modest redshifts. A robust measurement of 〈β〉 for the faintest galaxies at z≃ 7 (and indeed z≃ 8) remains a key observational goal, as it provides a fundamental test for high escape fractions from a potentially abundant source of re-ionizing photons. This goal is achievable with HST, but requires still deeper WFC3/IR imaging in the HUDF.
ABSTRACT We present 0 4 resolution extinction-independent distributions of star formation and dust in 11 star-forming galaxies (SFGs) at z = 1.3-3.0. These galaxies are selected from sensitive ...blank-field surveys of the 2′ × 2′ Hubble Ultra-Deep Field at λ = 5 cm and 1.3 mm using the Karl G. Jansky Very Large Array and Atacama Large Millimeter/submillimeter Array. They have star formation rates (SFRs), stellar masses, and dust properties representative of massive main-sequence SFGs at z ∼ 2. Morphological classification performed on spatially resolved stellar mass maps indicates a mixture of disk and morphologically disturbed systems; half of the sample harbor X-ray active galactic nuclei (AGNs), thereby representing a diversity of z ∼ 2 SFGs undergoing vigorous mass assembly. We find that their intense star formation most frequently occurs at the location of stellar-mass concentration and extends over an area comparable to their stellar-mass distribution, with a median diameter of 4.2 1.8 kpc. This provides direct evidence of galaxy-wide star formation in distant blank-field-selected main-sequence SFGs. The typical galactic-average SFR surface density is 2.5 M yr−1 kpc−2, sufficiently high to drive outflows. In X-ray-selected AGN where radio emission is enhanced over the level associated with star formation, the radio excess pinpoints the AGNs, which are found to be cospatial with star formation. The median extinction-independent size of main-sequence SFGs is two times larger than those of bright submillimeter galaxies, whose SFRs are 3-8 times larger, providing a constraint on the characteristic SFR (∼300 M yr−1) above which a significant population of more compact SFGs appears to emerge.
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