The forkhead protein, FOXA1, is a critical interacting partner of the nuclear hormone receptors, oestrogen receptor-α (ER) and androgen receptor (AR), which are major drivers of the two most common ...cancers, namely breast and prostate cancer. Over the past few years, progress has been made in our understanding of how FOXA1 influences nuclear receptor function, with both common and distinct roles in the regulation of ER or AR. Recently, another level of regulation has been described, with the discovery that FOXA1 is mutated in 1.8% of breast and 3-5% prostate cancers. In addition, a subset of both cancer types exhibit amplification of the genomic region encompassing the FOXA1 gene. Furthermore, there is evidence of somatic changes that influence the DNA sequence under FOXA1 binding regions, which may indirectly influence FOXA1-mediated regulation of ER and AR activity. These recent observations provide insight into the heterogeneity observed in ER and AR driven cancers.
In this paper, we develop theory about the relationship between supply network complexity and the traceability of adverse events. Because adverse events in complex supply networks are frequent and ...sometimes catastrophic, understanding how they happen is critical for the management of quality in complex supply networks. Drawing on literatures that deal with normal accidents, traceability, transparency and network complexity, we develop propositions that help explain how traceable adverse events will be in different types of supply networks. Drawing on examples from food supply networks, we illustrate the barriers to traceability associated with different types of complex network structure. We end by discussing managerial and academic implications for the design of traceability systems and supply networks.
The Drug Burden Index (DBI) was developed to assess patient exposure to medications associated with an increased risk of falling. The objective of this study was to examine the association between ...the DBI and medication-related fall risk.
The study used a retrospective cohort design, with a 1-year observation period. Participants (n = 1562) were identified from 31 community pharmacies. We examined the association between DBI scores and four outcomes. Our primary outcome, which was limited to participants who received a medication review, indexed whether the review resulted in at least one medication-related recommendation (e.g., discontinue medication) being communicated to the participant's health care provider. Secondary outcomes indexed whether participants in the full sample: (1) screened positive for fall risk, (2) reported 1+ falls in the past year, and (3) reported 1+ injurious falls in the past year. All outcome variables were dichotomous (yes/no).
Among those who received a medication review (n = 387), the percentage of patients receiving at least one medication-related recommendation ranged from 10.2% among those with DBI scores of 0 compared to 60.2% among those with DBI scores ≥1.0 (Chi-square (4)=42.4, p < 0.0001). Among those screened for fall risk (n = 1058), DBI scores were higher among those who screened positive compared to those who did not (Means = 0.98 (SD = 1.00) versus 0.59 (SD = 0.74), respectively, p < 0.0001).
Our findings suggest that the DBI is a useful tool that could be used to improve future research and practice by focusing limited resources on those individuals at greatest risk of medication-related falls.
Tuberous sclerosis complex (TSC) is a rare multi-system genetic disorder characterised by the presence of benign tumours throughout multiple organs including the brain, kidneys, heart, liver, eyes, ...lungs and skin, in addition to neurological and neuropsychiatric complications. Intracardiac tumour (rhabdomyoma), neurodevelopmental disorders (NDDs) and kidney disorders (KD) are common manifestations of TSC and have been linked with TSC1 and TSC2 loss-of-function mutations independently, but the dynamic relationship between these organ manifestations remains unexplored. Therefore, this study aims to characterise the nature of the relationship specifically between these three organs' manifestations in TSC1 and TSC2 mutation patients.
Clinical data gathered from TSC patients across South Wales registered with Cardiff and Vale University Health Board (CAV UHB) between 1990 and 2020 were analysed retrospectively to evaluate abnormalities in the heart, brain and kidney development. TSC-related abnormalities such as tumour prevalence, location and size were analysed for each organ in addition to neuropsychiatric involvement and were compared between TSC1 and TSC2 mutant genotypes. Lastly, statistical co-occurrence between organ manifestations co-morbidity was quantified, and trajectories of disease progression throughout organs were modelled.
This study found a significantly greater mutational frequency at the TSC2 locus in the cohort in comparison to TSC1. An equal proportion of male and female patients were observed in this group and by meta-analysis of previous studies. No significant difference in characterisation of heart involvement was observed between TSC1 and TSC2 patients. Brain involvement was seen with increased severity in TSC2 patients, characterised by a greater prevalence of cortical tubers and communication disorders. Renal pathology was further enhanced in TSC2 patients, marked by increased bilateral angiomyolipoma prevalence. Furthermore, co-occurrence of NDDs and KDs was the most positively correlated out of investigated manifestations, regardless of genotype. Analysis of disease trajectories revealed a more diverse clinical outcome for TSC2 patients: however, a chronological association of rhabdomyoma, NDD and KD was most frequently observed for TSC1 patients.
This study marks the first empirical investigation of the co-morbidity between congenital heart defects (CHD), NDDs, and KDs in TSC1 and TSC2 patients. This remains a unique first step towards the characterisation of the dynamic role between genetics, heart function, brain function and kidney function during the early development in the context of TSC.
Courses: This activity can be used in a wide range of classes, including interpersonal communication, introduction to communication, and small group communication
Objectives: After completing this ...activity, students should be able to: (1) define attribution theory, personality attribution, situational attribution, and attribution bias; (2) provide examples of both personality and situational attributions; and (3) recognize why and when each type of attribution is used. This activity provides students an opportunity to explore attribution theory and attribution bias in a low-stakes setting, where the ultimate goal is a deeper understanding of the theory itself. Therefore, this activity is typically not treated as a graded assignment, but rather an opportunity for exploration and discussion.
To understand the purpose acquisition of young emerging adults (18-23), scholars claim we need to learn the types of purposes to which they are committing and how they conceptualize purpose ...differently from other related concepts such as future goals and the good life. To address these issues, we examined interviews with 229 young emerging adults about their life purpose, future goals, and conceptions of the good life. Although the interviewees’ purposes and future goals fit within shared categories of achievement, relationships, religion, and moral concerns, important differences also emerged. While one fourth of the sample lacked purpose, no one lacked a vision for the good life or future goals. Moreover, their future vision of the good life focused more on individualistic concerns such as happiness, material acquisitions and personal experiences with family being the only communal interest.
Purpose
– The purpose of this paper is to make an initial attempt to understand if environmental and social sustainability practices of suppliers influence the buying decision and ultimate supplier ...selection in a purchasing organization.
Design/methodology/approach
– In order to test the effects of sustainability on sourcing decisions, this research utilizes two scenario-based behavioral experiments grounded in a transportation carrier selection context.
Findings
– Two scenario-based experiments with managerial participants were conducted and results suggest that environmental and social aspects of sustainability are indeed relevant sourcing considerations that impact both economic and relational aspects of exchange relationships. These sustainability aspects enable carriers to differentiate themselves in a highly commoditized market.
Originality/value
– Extant research advocates for sourcing organizations to take an active role in selecting sustainable suppliers. However, little is known about how supplier sustainability performance impacts sourcing decisions and supplier selection. This research addresses this gap in the literature and explores the effects of price, environmental, and social sustainability on purchase intentions and trust formation in a transportation carrier selection context.
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