We present a 0.16% precise and 0.27% accurate determination of R0, the distance to the Galactic center. Our measurement uses the star S2 on its 16-year orbit around the massive black hole Sgr A* that ...we followed astrometrically and spectroscopically for 27 years. Since 2017, we added near-infrared interferometry with the VLTI beam combiner GRAVITY, yielding a direct measurement of the separation vector between S2 and Sgr A* with an accuracy as good as 20 μas in the best cases. S2 passed the pericenter of its highly eccentric orbit in May 2018, and we followed the passage with dense sampling throughout the year. Together with our spectroscopy, in the best cases with an error of 7 km s−1, this yields a geometric distance estimate of R0 = 8178 ± 13stat. ± 22sys. pc. This work updates our previous publication, in which we reported the first detection of the gravitational redshift in the S2 data. The redshift term is now detected with a significance level of 20σ with fredshift = 1.04 ± 0.05.
We present the stellar kinematic maps of a large sample of galaxies from the integral-field spectroscopic survey CALIFA. The sample comprises 300 galaxies displaying a wide range of morphologies ...across the Hubble sequence, from ellipticals to late-type spirals. This dataset allows us to homogeneously extract stellar kinematics up to several effective radii. In this paper, we describe the level of completeness of this subset of galaxies withrespect to the full CALIFA sample, as well as the virtues and limitations of the kinematic extraction compared to other well-known integral-field surveys. In addition, we provide averaged integrated velocity dispersion radial profiles for different galaxy types, which are particularly useful to apply aperture corrections for single aperture measurements or poorly resolved stellar kinematics of high-redshift sources. The work presented in this paper sets the basis for the study of more general properties of galaxies that will be explored in subsequent papers of the survey.
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•High bioactive components reveals valorisation potential of the Cabernet pomace.•Yield of polyphenols has a direct correlation on the extraction conditions.•Ultrasound as a ...standalone is insufficient in enhancing yield of polyphenols.•Ultrasound with shaking involves low energy, accelerated and intensified polyphenols.•Results reveal sustainable polyphenols extraction from grape pomace.
The compositional analysis of Cabernet grape pomace showing higher polyphenols, dietary fiber and proteins reveals its potential to be valorised as a possible functional food. For assessment of potential intensification of polyphenols extraction yields, different extraction techniques under various operating conditions were experimented upon and further optimised. Ultrasonication as a standalone technique resulted in lower polyphenols yields. Whereas ultrasonication when combined with conventional shaking extractions and carried out under conditions of 45°C and 40:1 aqueous ethanolic solvent demonstrated higher yields of 2079.33mg/100g of dry grape pomace. The predictive yield as per statistical analysis was 2081.66mg/100g revealing a close agreement between experimental and theoretical values. Kinetic studies further showed that ultrasonication with subsequent shaking resulted in relatively lower activation energy causing greater and faster diffusion of the polyphenols into the solvent matrix. The outcome of this study reveals that grape pomace has significant antioxidant components like polyphenols; but maximum extraction yields involving lesser energy and time requires the involvement of a shorter ultrasonication in combination with conventional shaking extractions under optimized process control.
The prevalence of recreational cannabis use among adolescents is a growing public health concern due to its link to short- and long-term adverse effects on adolescents' wellbeing, physical health, ...mental health, and interpersonal behaviors.
Five databases were searched from inception to March 17, 2023, for exposure (nicotine product, alcohol) and outcome (recreational cannabis) in adolescents (persons aged 10-19 years). The studies were screened independently by two reviewers, and the quality of the studies was assessed with Newcastle Ottawa and AXIS tool. PRISMA guidelines were employed in this review.
Twenty-one (21) studies involving 2,778,406 adolescents were included in the appraisal and heterogeneity was found among these studies. Ascertainment bias was commonly detected in thirteen (13) of the included studies. Among the substances examined as potential exposures, nicotine-product use emerged as a significant factor associated with future cannabis use among adolescents, particularly in mid-adolescence and in places where recreational cannabis use has been legalized.
Current evidence suggests an association between nicotine-product use and subsequent recreational cannabis use among adolescents. However, further research is needed to establish causality between exposure to nicotine substances and the use of recreational cannabis within this age demographic. Additionally, there is a need for the development of prevention programs and targeted policies that continuously inform and update this vulnerable sub-population about the risks associated with cannabis use for leisure.
We study the time-variable linear polarisation of Sgr A* during a bright near-infrared flare observed with the GRAVITY instrument on July 28, 2018. Motivated by the time evolution of both the ...observed astrometric and polarimetric signatures, we interpret the data in terms of the polarised emission of a compact region (“hotspot”) orbiting a black hole in a fixed, background magnetic field geometry. We calculated a grid of general relativistic ray-tracing models, created mock observations by simulating the instrumental response, and compared predicted polarimetric quantities directly to the measurements. We take into account an improved instrument calibration that now includes the instrument’s response as a function of time, and we explore a variety of idealised magnetic field configurations. We find that the linear polarisation angle rotates during the flare, which is consistent with previous results. The hotspot model can explain the observed evolution of the linear polarisation. In order to match the astrometric period of this flare, the near horizon magnetic field is required to have a significant poloidal component, which is associated with strong and dynamically important fields. The observed linear polarisation fraction of ≃30% is smaller than the one predicted by our model (≃50%). The emission is likely beam depolarised, indicating that the flaring emission region resolves the magnetic field structure close to the black hole.
The flux distribution of Sgr A Abuter, R.; Amorim, A.; Bauböck, M. ...
Astronomy and astrophysics (Berlin),
06/2020, Letnik:
638
Journal Article
Recenzirano
Odprti dostop
The Galactic center black hole Sagittarius A* is a variable near-infrared (NIR) source that exhibits bright flux excursions called flares. When flux from Sgr A* is detected, the light curve has been ...shown to exhibit red noise characteristics and the distribution of flux densities is non-linear, non-Gaussian, and skewed to higher flux densities. However, the low-flux density turnover of the flux distribution is below the sensitivity of current single-aperture telescopes. For this reason, the median NIR flux has only been inferred indirectly from model fitting, but it has not been directly measured. In order to explore the lowest flux ranges, to measure the median flux density, and to test if the previously proposed flux distributions fit the data, we use the unprecedented resolution of the GRAVITY instrument at the VLTI. We obtain light curves using interferometric model fitting and coherent flux measurements. Our light curves are unconfused, overcoming the confusion limit of previous photometric studies. We analyze the light curves using standard statistical methods and obtain the flux distribution. We find that the flux distribution of Sgr A* turns over at a median flux density of (1.1 ± 0.3) mJy. We measure the percentiles of the flux distribution and use them to constrain the NIR
K
-band spectral energy distribution. Furthermore, we find that the flux distribution is intrinsically right-skewed to higher flux density in log space. Flux densities below 0.1 mJy are hardly ever observed. In consequence, a single powerlaw or lognormal distribution does not suffice to describe the observed flux distribution in its entirety. However, if one takes into account a power law component at high flux densities, a lognormal distribution can describe the lower end of the observed flux distribution. We confirm the rms–flux relation for Sgr A* and find it to be linear for all flux densities in our observation. We conclude that Sgr A* has two states: the bulk of the emission is generated in a lognormal process with a well-defined median flux density and this quiescent emission is supplemented by sporadic flares that create the observed power law extension of the flux distribution.
Neoepitopes arising from amino acid substitutions due to single nucleotide polymorphisms are targets of T cell immune responses to cancer and are of significant interest in the development of cancer ...vaccines. However, understanding the characteristics of rare protective neoepitopes that truly control tumor growth has been a challenge, due to their scarcity as well as the challenge of verifying true, neoepitope-dependent tumor control in humans. Taking advantage of recent work in mouse models that circumvented these challenges, here, we compared the structural and physical properties of neoepitopes that range from fully protective to immunologically inactive. As neoepitopes are derived from self-peptides that can induce immune tolerance, we studied not only how the various neoepitopes differ from each other but also from their wild-type counterparts. We identified multiple features associated with protection, including features that describe how neoepitopes differ from self as well as features associated with recognition by diverse T cell receptor repertoires. We demonstrate both the promise and limitations of neoepitope structural analysis and predictive modeling and illustrate important aspects that can be incorporated into neoepitope prediction pipelines.
► Robust electrochemical immunosensor for detection of human coeliac disease related antibodies. ► Good performace in real human serum media with little non-specific binding. ► Semi-quantitative ...results matching commercial ELISA kits.
The determination of antigliadin antibodies from human serum samples is of vital importance for the diagnosis of an autoimmune disease such as celiac disease. An electrochemical immunosensor that mimics traditional ELISA type architecture has been constructed for the detection of antigliadin antibodies with control over the orientation and packing of gliadin antigen molecules on the surface of gold electrodes. The orientation of the antigen on the surface has been achieved using a carboxylic-ended bipodal alkanethiol that is covalently linked with amino groups of the antigen protein. The bipodal thiol presents a long poly(ethyleneglycol)-modified chain that acts as an excellent non-specific adsorption barrier. The bipodal nature of the thiol ensured a good spacing and hence good diffusion properties of electroactive species through the self-assembled monolayer, which is vital for the efficiency of the constructed electrochemical immunosensor.
The electrochemical immunosensor was characterized using surface plasmon resonance as well as electrochemical impedance spectroscopy. Amperometric evaluation of the sensor with polyclonal antigliadin antibodies showed stable and reproducible low limits of detection (46
ng/mL; % RSD
=
8.2,
n
=
5). The behaviour and performance of the electrochemical immunosensor with more complex matrixes such as reference serum solutions and real patient samples was evaluated and compared with commercial ELISA kits demonstrating an excellent degree of correlation in thirty minutes total assay time; the electrochemical immunosensor not only delivers a positive or negative result, it allows the estimation of semi-quantitative antibody contents based on the comparison against clinical reference solutions.
Currently, there is a considerable controversy over the participation of Treg cells during Trypanosoma cruzi infection, the main point being whether these cells play a negative or a positive role. In ...this work, we found that the adoptive transfer of CD4+CD25+FOXP3+ T cells from rSSP4- (a recombinant Trypanosoma cruzi amastigote derived protein, previously shown to have immunomodulatory properties on macrophages) immunized BALB/c donors into syngenic recipients simultaneously with T. cruzi challenge reduces cardiac inflammation and prolongs hosts’ survival but increases blood parasitemia and parasite loads in the heart. These CD4+CD25+FOXP3+ Treg cells from immunized mice have a relatively TGF-β-dependent suppressive activity on CD4+ T cells. Therefore, regulatory CD4+CD25+ T cells play a positive role in the development of acute T. cruzi infection by inducing immunosuppressive activity that controls early cardiac inflammation during acute Chagas disease, prolonging survival, but at the same time promoting parasite growth.
We use VLTI/GRAVITY near-infrared interferometry measurements of eight bright type 1 AGN to study the size and structure of hot dust that is heated by the central engine. We partially resolve each ...source, and report Gaussian full width at half-maximum sizes in the range 0.3−0.8 mas. In all but one object, we find no evidence for significant elongation or asymmetry (closure phases ≲1°). The narrow range of measured angular sizes is expected given the similar optical flux of our targets, and implies an increasing effective physical radius with bolometric luminosity, as found from previous reverberation and interferometry measurements. The measured sizes for Seyfert galaxies are systematically larger than for the two quasars in our sample when measured relative to the previously reported
R
∼
L
1/2
relationship, which is explained by emission at the sublimation radius. This could be evidence of an evolving near-infrared emission region structure as a function of central luminosity.
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