.
Archaeological Roman lead (Pb) is known to be a suitable material for shielding experimental apparata in rare event searches. In the past years the intrinsic radiopurity of this material was ...investigated using different technologies. In this work we applied the latest advancements in cryogenic techniques to study the bulk radiopurity of a 1cm^3 sample of archaeological Roman Pb. We report the lowest ever measured limit on
210
Pb content in Roman Pb, with a concentration lower than 715μBq/kg. Furthermore, we also studied
238
U and
232
Th impurity concentrations. Our values concur with independent measurements reported in literature.
We present the performances of a 330 g zinc molybdate (ZnMoO
4
) crystal working as scintillating bolometer as a possible candidate for a next generation experiment to search for neutrinoless double ...beta decay of
100
Mo. The energy resolution, evaluated at the 2615 keV
γ
-line of
208
Tl, is 6.3 keV FWHM. The internal radioactive contaminations of the ZnMoO
4
were evaluated as <6 μBq/kg (
228
Th) and 27±6 μBq/kg (
226
Ra). We also present the results of the
α
vs
β
/
γ
discrimination, obtained through the scintillation light as well as through the study of the shape of the thermal signal alone.
Tumor regression after antiviral therapy (AT) is in favor of an etiological role of hepatitis C virus (HCV) in non-Hodgkin's B-cell lymphomas (NHL).
We carried out a cohort study of 704 consecutive ...HIV-negative, HCV-positive patients with indolent NHL diagnosed and treated from 1993 to 2009 in 39 centers of the Fondazione Italiana Linfomi; 134 patients were managed with AT for lymphoma control.
For entire cohort, 5-year overall survival (OS) was 78% 95% confidence interval (CI): 74%–82% and 5-year progression-free survival (PFS) was 48% (95% CI: 44%–53%). In multivariate analysis, the use of AT during the patients’ life had positive impact on OS. Forty-four of the 100 patients treated with first-line AT achieved a complete remission (CR) and 33 a partial response (PR). HCV-RNA clearance was achieved in 80 patients and was related to lymphoma response. At a median follow-up of 3.6 years, 5-year PFS was 63% (95% CI: 50%–73%). CR + PR rate was 85% with AT as second-line treatment.
AT produces HCV-RNA clearance and consequent tumor regression in most patients with HCV-related indolent NHL. AT used at any time is associated with improved OS. Consequently, AT can be considered an option for patients with indolent lymphomas who do not need immediate cytoreductive treatment.
•A technique for active cancellation of Pulse Tube (PT) vibrational noise is proposed.•The technique controls the relative phase of the pressure waves of two or more PTs.•A scan of the phase ...parameter space allows to find the lowest noise configuration.•The PTs are driven locking their relative phases in the optimal working condition.
The Cryogenic Underground Observatory for Rare Events (CUORE) experiment at Gran Sasso National Laboratory of INFN searches for neutrinoless double beta decay using TeO2 crystals as cryogenic bolometers. The sensitivity of the measurement heavily depends on the energy resolution of the detector, therefore the success of the experiment stands on the capability to provide an extremely low noise environment. One of the most relevant sources of noise are the mechanical vibrations induced by the five Pulse Tube cryocoolers used on the cryogenic system which houses the detectors. To address this problem, we developed a system to control the relative phases of the pulse tube pressure oscillations, in order to achieve coherent superposition of the mechanical vibrations transmitted to the detectors. In the following, we describe this method and report on the results in applying it to the CUORE system.
PDF
